Photosensitivity caused by chloroquine

Weelden, H. van

doi:10.1001/archderm.118.5.290b

Cited by 17 publications

(7 citation statements)

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“…- Many cases of phototoxic, photoallergic dermatitis and photosensitivity caused by CQ and HCQ [28,29,30] have also been reported and some HCQ CADR were triggered by light (AGEP [31] and TEN [32]). Qu [33,34,35,36] and Qud [37,38,39,40] induced many cases of photosensitivity.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests

et al. 2015

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Background: Currently used antimalarial drugs (AM) are hydroxychloroquine and chloroquine, which are prescribed for many autoimmune disorders. The value of skin tests on cutaneous adverse drug reactions (CADR) with AM remains unknown. Objective: The main objective of this retrospective study is to know whether skin tests for AM are useful and how to manage the recovery of AM therapy in these patients. Methods: All patients referred for suspected CADR secondary to AM between 2001 and 2014 in eight French dermatology centers were retrospectively reviewed. Results: We report herein a retrospective series of 20 patients with CADR and AM involvement. Skin tests, performed in 14/20 patients, were negative in all cases. Six patients had an oral provocation test with recurrence of CADR in 1 case. Conclusion: We encourage dermatologists to perform oral provocation tests in nonsevere CADR in order to allow AM rechallenge at progressive doses.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests

et al. 2015

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“…In this case, the combination of sunburn and hydroxychloroquine is the likely cause, and this is supported by the marked sparing of skin areas protected by the swimming costume. Although hydroxychloroquine is used for its photoprotective properties, phototoxic and photoallergic reactions occur with the drug 5,6 . It is suggested that the expression of intercellular cell adhesion molecule‐1 triggered by ultraviolet (UV)‐induced cytokines is the reason for the morphology of the eruption 7–9 …”

Section: Reportmentioning

confidence: 99%

Hydroxychloroquine-associated, photo-induced toxic epidermal necrolysis

Callaly

FitzGerald

Rogers

2008

Clinical and Experimental Dermatology

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“…Knox and co-workers 115 demonstrated in experimental animals that CQ reduces the erythematous and carcinogenic response to UV light. However, some authors suspect that CQ may sometimes cause light sensitivity, 120 but this seems to be a rare event. Seideman and Ros 121 have phototested 25 rheumatoid arthritis patients during current treatment with and without CQ.…”

Section: Photoprotective Effects and Evidence That Antimalarials Might Provide Bene T From Direct Local Effects Within The Skinmentioning

confidence: 99%

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

Woźniacka

Carter

McCauliffe

2002

Lupus

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Antimalarials are arguably the best modality currently available for treating patients with cutaneous lupus erythematosus (LE). Although antimalarials have been used for decades in treating cutaneous LE, the precise mechanisms by which they provide therapeutic benefit are not well defined. The putative mechanisms by which antimalarials might provide therapeutic benefit to patients with cutaneous LE include a number of interrelated anti-inflammatory and immunosuppressive effects that include photoprotection, lysosomal stabilization, suppression of antigen presentation, and inhibition of prostaglandin and cytokine synthesis. If we had a more precise understanding of how antimalarials provide therapeutic benefit in cutaneous LE we might gain better insight into the pathogenic mechanisms of LE and ways of developing better therapies for afflicted patients.

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Photosensitivity caused by chloroquine

Cited by 17 publications

References 0 publications

Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests

Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests

Hydroxychloroquine-associated, photo-induced toxic epidermal necrolysis

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

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