Photosensitive Precursors to Nitric Oxide

Pavlos, Christopher M.; Xu, Hua; Toscano, John P.

doi:10.2174/1568026054679326

Cited by 36 publications

(18 citation statements)

References 76 publications

(111 reference statements)

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“…Several photosensitive metal compounds including SNP, Fe—S—NO clusters known as Roussin’s salts, and simple Ru complexes like [Ru(NO)(Cl) 5 ] 2− , have been used as controlled sources of NO to elucidate the biological and notably neurophysiological roles of NO in cells and tissues; however, these complexes all suffer from undesirable side reactions 144,145. In addition to release of toxic side products like cyanide, the NO is lost prior to photolysis either thermally or by conversion to other NO x products in the case of the Fe—NO compounds, or the metal itself reacts with biomolecules as in the case of Ru forming DNA adducts 144,145.…”

Section: Metal Complexes That Bind/release Small Moleculesmentioning

confidence: 99%

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

2009

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The principles governing metal-ligand complex stability and specificity depend on the properties of both the metal ion and the chelating agent, as summarized briefly in the following sections. More comprehensive reviews on ligand design for selective complexation of metal ions in aqueous solution are available. [40][41][42][43][44][45] This discussion sets the stage for understanding the properties of the compounds presented throughout this review.

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Section: Metal Complexes That Bind/release Small Moleculesmentioning

confidence: 99%

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

2009

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“…The advent of a new generation of tools for monitoring NO and other gases, as well as targeted manipulations of the gas-producing machinery and downstream effector molecules, will help determine the extent of gaseous retrograde signaling in the brain (Du et al, 2008; Lim and Lippard, 2007; Pavlos et al, 2005; St Croix et al, 2005). …”

Section: Different Systems That Mediate Retrograde Signalingmentioning

confidence: 99%

Activity-Dependent Regulation of Synapses by Retrograde Messengers

Regehr

Carey

Best

2009

Neuron

242

226

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Summary Throughout the brain postsynaptic neurons release substances from their cell bodies and dendrites that regulate the strength of the synapses they receive. Diverse chemical messengers have been implicated in retrograde signaling from postsynaptic neurons to presynaptic boutons. Here we provide an overview of the signaling systems that lead to rapid changes in synaptic strength. We consider the capabilities, specializations and physiological roles of each type of signaling system.

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“…Various derivatized NONOates have been reported which are pro-prodrugs, designed to confer some cell or tissue selectivity by using metabolic bioactivation. In the third article, derivatized photolabile NONOates are discussed amongst other approaches to caged NO photochemical sources and potential photodynamic therapy [11]. This latter article includes some discussion of organometallic NO donors, the most venerable of which is sodium nitroprusside, in use as a clinical nitrovasodilator for 80 years.…”

Section: Approachesmentioning

confidence: 99%

An Introduction to NO-related Therapeutic Agents

Thatcher

2005

CTMC

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Investigational NO-related therapeutic agents span the range from prodrugs that elevate NO levels, to scavengers of NO, and inhibitors of endogenous NO synthesis. Related agents that influence nitrogen oxides, in addition to NO itself, are also to be considered. Organic nitrates have been used for over 130 years in cardiovascular therapy and hybrid nitrates continue to lead the way in clinical development for an increasing range of disease states. Selectivity for inhibition of NO synthase (NOS) isoforms is a continuing goal. Conversely, N-hydroxyarginine derivatives are substrates for NOS and represent a new NO donor class. Diazeniumdiolate (NONOate) NO donors have been essential for understanding of NO biology and are being developed as NO donor and HNO donor prodrugs including as photolabile sources. N-Hydroxyurea has been used as a cancer drug for decades and is approved for sickle cell disease treatment, but also provides a lead compound for design of NO and HNO donors. Nitroaliphatics and nitrosoaliphatics also represent chemical classes that include NO donors and exhibit biological activity that mimics that of NO. Nitroprusside has been in use since the 1920's and metal ion complexes continue to be explored, including as caged NO donors. Clear and exciting opportunities exist for new therapies based upon NO-related drugs. Despite the extensive clinical use of NO donor drugs and the role of NOS activation in the action of several prescription medications, challenges remain to the development of new NO-related therapeutics, but these are surmountable and are outweighed by the opportunities.

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Photosensitive Precursors to Nitric Oxide

Cited by 36 publications

References 76 publications

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

Activity-Dependent Regulation of Synapses by Retrograde Messengers

An Introduction to NO-related Therapeutic Agents

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