Photosensitive Liposomes as Potential Targeted Therapeutic Agents

Abstract

This work describes the synthesis of a hexadecyl‐modified anthracene‐based photoacid generator for use as alight‐activated trigger, which will induce contents release from phospholipid1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine (DOPE):lysoplasmenylcholine liposomes. The liposomes containing photosensitizers such as bacteriochlorophylla or aluminum phthalocyaninetetrasulfonate are also described. Finally, biodistribution of aluminum phthalocyaninetetrasulfonate loaded liposomes in a murine tumor xenograft model is discussed.