Photosensitive atopic dermatitis – a neglected subset: Clinical, laboratory, histological and photobiological workup

Ellenbogen, Eran; Wesselmann, Ulrich; Hofmann, Silke; Lehmann, Percy

doi:10.1111/jdv.13451

Cited by 25 publications

(30 citation statements)

References 21 publications

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“…It is believed that the majority of CAD patients have photoallergy and contact allergy, often to airborne allergens, such as fragrances, plant antigens and medication 8,9 . Ellenbogen et al 10 . proposed the concept of photosensitive atopic dermatitis, the clinical features of which include atopic diathesis, eczematous lesions in UV radiation‐exposed body regions and positive photoprovocation reactions, which may be misdiagnosed as CAD.…”

Section: Discussionmentioning

confidence: 99%

Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes

Wang

Gong

Rong

et al. 2020

The Journal of Dermatology

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Chronic actinic dermatitis (CAD) is a common debilitating photodermatosis. Patients often have to completely avoid outdoor activities, which severely impacts their quality of life. Phototherapy is effective for CAD and seems to increase patients’ tolerance towards sunlight and consequently decrease the extent of disease. Unfortunately, the slower onset and time‐consuming nature of phototherapy limits the clinical application. Considering the effectiveness and time‐saving nature of ultraviolet (UV)‐A rush hardening in solar urticaria, we performed a pilot study to determine whether UV‐A rush hardening is effective in CAD. Six patients with CAD were exposed to multiple sessions of UV‐A for 4–5 days at 1‐h intervals/day. Subsequently, maintenance UV‐A exposure was performed at 1–2‐week intervals. Phototesting at baseline showed that three patients were sensitive to both UV‐A and ‐B, and the other three patients only showed UV‐A sensitivity. All of the patients responded well to UV‐A rush hardening and four (67%) maintained a good remission status after 1 year. The results of this pilot study suggest that UV‐A rush hardening phototherapy is effective and well tolerated in the treatment of CAD, while future larger prospective studies using objective scores of disease activity and quality of life are needed.

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Section: Discussionmentioning

confidence: 99%

Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes

Wang

Gong

Rong

et al. 2020

The Journal of Dermatology

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“…The majority of AD patients benefit from UV radiation therapy and from exposure to the sun in a controlled natural setting [11,12]. However, an estimated 10% of patients are reported to show photoaggravation [13]. At least two studies from Japan have reported patients with AD who suffer from recalcitrant facial erythema related to sun exposure [14,15].…”

Section: Ultraviolet (Uv) Radiation and Skin Barrier Dysfunctionmentioning

confidence: 99%

“…Also, some skincare products and comorbidities such as polymorphous light eruption could mask or worsen the sensitivity to UV radiation [17]. In a retrospective analysis of 17 patients with longstanding AD who suddenly developed photosensitivity to UVA, the onset of photosensitivity was reported during spring and summer and during exposure to artificial UVR as part of the patients' treatment regimen [13].…”

Section: Ultraviolet (Uv) Radiation and Skin Barrier Dysfunctionmentioning

confidence: 99%

The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis

Piquero-Casals¹,

Carrascosa

Morgado‐Carrasco

et al. 2021

Dermatol Ther (Heidelb)

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Atopic dermatitis (AD) is a chronic inflammatory skin disease with an estimated prevalence of 10–15% in children and 2–10% in adults. Clinically, there is notable phenotypic variability driven by a complex interaction between genetics, immune function, and the environment. Impairment of the skin barrier plays a significant role in the pathogenesis of AD. The apparent beneficial effect of sunlight in patients with atopic eczema is questioned due to its capacity to disrupt the skin barrier and generate free radicals that can damage proteins, lipids, and DNA. The sum of the external factors that an individual is exposed to throughout their lifetime is termed the exposome. Environmental factors such as sun exposure, temperature, and humidity contribute to both AD flares and regional prevalence variation. Literature on photoprotection in atopic dermatitis is very scarce. The use of adequate sunscreens in atopic dermatitis can ensure the level of photoprotection required to prevent skin photoaging and skin cancer and to mitigate skin barrier dysfunction, decrease inflammation, and neutralize facial redness. Herein we discuss and review the role of UV radiation and the exposome in the etiology of AD, as well as the role of adequate photoprotection.

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“…Im Laufe der Jahre hat sich so eine sehr fruchtbare wissenschaftliche Interaktion herausgebildet mit zahlreichen Forschungsaufenthalten in beiden Ländern. Eine Auswahl daraus entstandener Veröffentlichungen ist in der Literatur widergegeben .…”

Section: Abbildungunclassified

Überwältigende Gastfreundschaft der Israelischen Dermatologischen Gesellschaft anlässlich der 40. dermatologischen Jahrestagung in Eilat unter dem Motto: GET C‐O‐N‐N‐E‐C‐T‐E‐D

Lehmann

2019

J Deutsche Derma Gesell

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Photosensitive atopic dermatitis – a neglected subset: Clinical, laboratory, histological and photobiological workup

Cited by 25 publications

References 21 publications

Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes

Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes

The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis

Überwältigende Gastfreundschaft der Israelischen Dermatologischen Gesellschaft anlässlich der 40. dermatologischen Jahrestagung in Eilat unter dem Motto: GET C‐O‐N‐N‐E‐C‐T‐E‐D

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