Photosensitiser functionalised luminescent upconverting nanoparticles for efficient photodynamic therapy of breast cancer cells

Buchner, Markus; Calavia, Paula García; Muhr, Verena; Kröninger, Anna; Baeumner, Antje J.; Hirsch, Thomas; Russell, David A.; Marín, María J.

doi:10.1039/c8pp00354h

Cited by 28 publications

(23 citation statements)

References 42 publications

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“…With regard to therapeutic applications, one recent study used UCNPs to direct PDT in breast cancer cells . UCNPs were functionalized with lysine and rose bengal (RB), a photosensitizer that generates singlet oxygen capable of killing cells.…”

Section: Cellular Tissue and In Vivo Imaging And Theranosticsmentioning

confidence: 99%

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

et al. 2021

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Research related to the development and application of luminescent nanoparticles (LNPs) for chemical and biological analysis and imaging is flourishing. Novel materials and new applications continue to be reported after two decades of research. This review provides a comprehensive and heuristic overview of this field. It is targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications. Numerous LNP materials are cataloged by fundamental descriptions of their chemical identities and physical morphology, quantitative photoluminescence (PL) properties, PL mechanisms, and surface chemistry. These materials include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, carbon dots, nanodiamonds, luminescent metal nanoclusters, lanthanidedoped upconversion nanoparticles and downshifting nanoparticles, triplet−triplet annihilation nanoparticles, persistent-luminescence nanoparticles, conjugated polymer nanoparticles and semiconducting polymer dots, multi-nanoparticle assemblies, and doped and labeled nanoparticles, including but not limited to those based on polymers and silica. As an exercise in the critical assessment of LNP properties, these materials are ranked by several application-related functional criteria. Additional sections highlight recent examples of advances in chemical and biological analysis, point-of-care diagnostics, and cellular, tissue, and in vivo imaging and theranostics. These examples are drawn from the recent literature and organized by both LNP material and the particular properties that are leveraged to an advantage. Finally, a perspective on what comes next for the field is offered.

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Section: Cellular Tissue and In Vivo Imaging And Theranosticsmentioning

confidence: 99%

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

et al. 2021

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“…PDT is a new treatment method that can directly kill tumor cells or promote tumor cell apoptosis by releasing a large amount of ROS under the stimulation of photosensitizer (a kind of non‐toxic light sensitive compound) at a certain wavelength. It is an advanced and effective approach to killing tumor cells, especially in superficial tumors such as breast, [16] oral [17] and skin [18] cancers. Table 1 summarizes recent studies on the treatment of cancer by regulating intracellular ROS levels via PDT.…”

Section: Multiple Ros‐mediated Treatment Strategiesmentioning

confidence: 99%

Nano Drug Delivery Systems: Effective Therapy Strategies to Overcome Multidrug Resistance in Tumor Cells

Shen

Sun

et al. 2022

ChemistrySelect

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Multidrug resistance (MDR) of tumor cells refers to the fact that tumor cells are resistant to one drug while also to others with different types and structures. MDR is an important reason for the failure of many chemotherapies. And researchers have been trying to break through this fatal problem for a long time. Fortunately, the rapid development of nano drugs in recent years has brought new ideas to overcome the MDR. Based on its inherent small size and easy modification characteristics, nano drug can easily reach tumor cells and prolong the circulation time in vivo. This review summarizes three most extensive and in‐depth strategies for counteracting MDR based on nano drug delivery systems, including: 1) controlling ROS levels and stimulus response; 2) co‐delivery of P‐gp inhibitors; 3) directly targeting the nucleus. Furthermore, other innovative and cutting‐edge anti‐MDR strategies are also discussed in this review. It is hoped that the overview of the above treatment strategies can provide inspiration for the design of anti‐cancer nano drugs in the future.

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“…In the latter case, the process that is in the end responsible for the excitation of the photosensitizer is not a direct two-photon absorption but rather a sequential process involving the lanthanide ions. This has an important advantage of not requiring femtosecond laser excitation but just pumping the lanthanide (ytterbium in that case) at its absorption band in the NIR with a continuous wave (CW) laser diode [238][239][240].…”

Section: Nanocontainers With Nanoparticles and Photosensitizersmentioning

confidence: 99%

Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

et al. 2021

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The use of two-photon absorption (TPA) for such applications as microscopy, imaging, and photodynamic therapy (PDT) offers several advantages over the usual one-photon excitation. This creates a need for photosensitizers that exhibit both strong two-photon absorption and the highly efficient generation of reactive oxygen species (ROS), as well as, ideally, bright luminescence. This review focuses on different strategies utilized to improve the TPA properties of various multi-photon absorbing species that have the required photophysical properties. Along with well-known families of photosensitizers, including porphyrins, we also describe other promising organic and organometallic structures and more complex systems involving organic and inorganic nanoparticles. We concentrate on the published studies that provide two-photon absorption cross-section values and the singlet oxygen (or other ROS) and luminescence quantum yields, which are crucial for potential use within PDT and diagnostics. We hope that this review will aid in the design and modification of novel TPA photosensitizers, which can help in exploiting the features of nonlinear absorption processes.

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Photosensitiser functionalised luminescent upconverting nanoparticles for efficient photodynamic therapy of breast cancer cells

Abstract: Rose Bengal functionalised upconverting nanoparticles produce singlet oxygen via efficient FRET following NIR excitation and have been used for the photodynamic therapy treatment of breast cancer cells.

Cited by 28 publications

References 42 publications

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Nano Drug Delivery Systems: Effective Therapy Strategies to Overcome Multidrug Resistance in Tumor Cells

Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence

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