Introduction and Objectives:Patients diagnosed with interstitial cystitis/ bladder pain syndrome (IC/BPS) represent a heterogeneous group of clinical phenotypes. The presence of Hunner's lesions presents an opportunity for objective classification into those with Hunner's lesion IC/BPS (classic IC) and those with non-Hunner's lesion BPS. While currently, a diagnosis of Hunner's lesion IC/BPS requires cystoscopy, limited data exist suggesting that these subtypes can be distinguished without endoscopic examination based on the degree of bladder-focused centricity and infrequent association with generalized pain conditions. Methods: Patients from a prospective, single-centre database of IC/BPS patients who had documented cystoscopic findings were categorized as those with Hunner's lesion IC/BPS and non-Hunner's lesion BPS. Their demographics, pain and symptom scores, voiding symptoms, presence of IBS, and clinical UPOINT scoring were comparatively analyzed. Results: A total of 469 patients were reviewed. Of those, 359 had documented local anesthetic cystoscopic findings; 44 (12.3%) with Hunner's lesion IC/BPS and 315 (87.7%) with non-Hunner's BPS. Patients with Hunner's lesions were older (p=0.004), had greater urinary frequency (p=0.013), more nocturia (p=0.0004), and higher ICSI scores (p=0.017). There was no difference in number of UPOINT phenotype domains reported, overall UPOINT scores or prevalence of IBS between the groups. Conclusions: A subtype of IC with Hunner's lesions has worse bladdercentric symptoms, but did not have a distinct bladder-centric phenotype. Given the management implications of distinguishing classic IC from nonHunner's lesion BPS, we recommend routine cystoscopy with local anesthesia for all patients with a suspected diagnosis of IC/BPS. 3 Medicine, Dalhousie University, Halifax, NS, Canada; 4 Surgery, University of Toronto, Toronto, ON, Canada Introduction and Objectives: Several small studies suggest prostate cancer treatment, including radical prostatectomy (RP) and radiation (XRT), may be associated with the development of overactive bladder (OAB). The rate of OAB following treatment for prostate cancer has not yet been investigated at the population level. The purpose of this study was to determine the proportion of men who are prescribed anticholinergic medications after being treated for prostate cancer with radiation compared to surgery, as a marker of estimating the proportion of men with OAB following treatment of prostate cancer.
MP-08.02 Prescription of anticholinergic medication following treatment of localized prostate cancer
Methods:We conducted a population-based, retrospective cohort study comparing men treated for localized prostate cancer with XRT to men treated with RP between 1997 and 2012 in Ontario, Canada. Hospital administrative data and data from the Ontario Cancer Registry (OCR) and the Ontario Drug Benefit (ODB) plan were used. The primary outcome was the prescription of an anticholinergic medication (Ach) after the completion of prostate cancer treatment def...