Photoselective Vaporization of the Prostate with GreenLight 120-W Laser Compared with Monopolar Transurethral Resection of the Prostate: A Multicenter Randomized Controlled Trial

Lukacs, B.; Loeffler, Joyce; Bruyère, F.; Blanchet, Pascal; Gelet, A.; Coloby, P.; Taille, Alexandre de la; Lemaire, Philippe; Baron, Jean-Christophe; Cornu, Jean‐Nicolas; Aout, Mounir; Rousseau, Hélène; Vicaut, Éric

doi:10.1016/j.eururo.2012.01.052

Cited by 145 publications

(107 citation statements)

References 19 publications

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“…Studies from Lukacs, Capitan and Al-Ansari 3,5,14 have all shown similar findings with PVP as shown in our study. In a recent editorial, Madersbacher questioned the validity of these trials nicely summarizing the difficulty of recruiting suitable patients in a timely fashion as newer models of the technologies evolve.…”

Section: Discussionsupporting

confidence: 79%

A prospective trial of GreenLight PVP (HPS120) versus transurethral resection of the prostate in the treatment of lower urinary tract symptoms in Ontario, Canada

Whelan

Bowen²,

Burke³

et al. 2013

CUAJ

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Background: Photoselective vaporization of the prostate (PVP) is a bloodless, relatively painless alternative to transurethral resection of the prostate (TURP) for relief of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). Objective: We compare the effectiveness, safety and cost-effectiveness of Greenlight Laser PVP (HPS-120) and TURP. Methods: We conducted a prospective, non-randomized trial in 3 Ontario centres from March 2008 to February 2011. Assessments were completed at baseline, 1 and 6 months following surgery at the physicians' offices and at 12 and 24 months by phone. The primary outcome was the change in International Prostate Symptoms Score (IPSS) score at 6 months versus baseline. Secondary outcomes were changes in flow rate, postvoid residual (PVR), prostate-specific antigen (PSA) and sexual health inventory for men (SHIM) scores. Adverse events, health-related quality of life (HRQoL), resource utilization and productivity losses were collected. Results: Although the IPSS decreased in both arms (n = 140 for PVP and n = 24 for TURP) between baseline and 6 months, the difference in change over time between the groups was not statistically significant (p = 0.718). Other outcomes improved equally from baseline and 6 months (Qmax, SHIM, PSA and HRQoL), with only changes in PVR favouring PVP (p = 0.018). There were no statistical differences in serious adverse events. In total, 130 of 140 PVP patients were outpatients, all TURP subjects were inpatients. PVP was less costly than TURP ($3891 vs. $4863; p < 0.001) with similar quality-adjusted life years (0.448 vs. 0.441; p = 0.658). Conclusion: Greenlight Laser PVP (HPS-120) is a safe and costeffective alternative to TURP for outpatient treatment of LUTS and can be completed as an outpatient with minimal blood loss.

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Section: Discussionsupporting

confidence: 79%

A prospective trial of GreenLight PVP (HPS120) versus transurethral resection of the prostate in the treatment of lower urinary tract symptoms in Ontario, Canada

Whelan

Bowen²,

Burke³

et al. 2013

CUAJ

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“…The study echoes the safety and efficacy of other studies examining the 120 W laser [18][19][20][21][22]. Lukacs, et al reported on the REVAPRO study, the largest randomized controlled trial of a group of 139 patients undergoing 120 W PVP vs. monopolar TURP [22].…”

Section: Discussionmentioning

confidence: 56%

“…Lukacs, et al reported on the REVAPRO study, the largest randomized controlled trial of a group of 139 patients undergoing 120 W PVP vs. monopolar TURP [22]. Although IPSS scores were not significantly different between the two groups at 12 months (6 vs. 5, respectively, p = 0.494), the study was not able to demonstrate noninferiority of PVP as originally intended.…”

Section: Discussionmentioning

confidence: 96%

Comparison of 80 W versus 120 W 532 nm Laser Prostatectomy for BPH

Lee¹

2013

OJU

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Purpose: Improvements to photoselective vaporization of the prostate (PVP) have been made over time, particularly with the introduction of higher power systems. Few studies however have compared the performance of these systems to their predecessors. Baseline parameters were similar between the two groups except for greater median age (72.8 vs. 69.2 years, p = 0.01) and lower median PSA (2.0 vs. 3.3, p = 0.01) in the 80 W group. Median laser time was longer in the 80W group (85 vs. 51 minutes, p < 0.001) with a higher median energy utilized (253 vs. 210 kJ, p = 0.001). Final IPSS, Qmax, PVR, and PSA were equivalent between the two groups. Conclusions: In our series, PVP was safe and effective. Durable and similar improvements in symptoms and objective parameters were achieved in patients with both 80 W and 120 W laser systems. PVP with the 120 W system, however, provided faster and more efficient vaporization compared to the 80 W system.

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“…The short-term complication rate with the Thulium laser is similar to the rate described after vaporization with other laser systems [16][17][18][19][20][21] and less than that with TUR-P. Thus, Thulium vaporization of the prostate has established as a standard procedure in many urological departments including ours.…”

Section: Introductionmentioning

confidence: 50%

1084 Is absorption of irrigation fluid a problem in thulium laser vaporization of the prostate? A prospective investigation using the expired breath ethanol test

Schwab¹,

Müllhaupt²,

Mordasini³

et al. 2016

European Urology Supplements

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Photoselective Vaporization of the Prostate with GreenLight 120-W Laser Compared with Monopolar Transurethral Resection of the Prostate: A Multicenter Randomized Controlled Trial

Cited by 145 publications

References 19 publications

A prospective trial of GreenLight PVP (HPS120) versus transurethral resection of the prostate in the treatment of lower urinary tract symptoms in Ontario, Canada

A prospective trial of GreenLight PVP (HPS120) versus transurethral resection of the prostate in the treatment of lower urinary tract symptoms in Ontario, Canada

Comparison of 80 W versus 120 W 532 nm Laser Prostatectomy for BPH

1084 Is absorption of irrigation fluid a problem in thulium laser vaporization of the prostate? A prospective investigation using the expired breath ethanol test

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