Photoreversible fragmentation of a liquid interface for micro-droplet generation by light actuation

Diguet, Antoine; Li, Hao; Queyriaux, Nicolas; Chen, Yong; Baigl, Damien

doi:10.1039/c1lc20328b

Cited by 50 publications

(48 citation statements)

References 35 publications

(16 reference statements)

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“…49 The system is reversible, and cis -AzoTAB isomerizes back to trans configuration upon blue light (475 nm) illumination (Figure 1A). AzoTAB has been mainly used for the photocontrol of surface tension, 50,51 DNA conformation, 49,52,53 and gene expression systems. 54−56 Here, we investigated how light affected the behavior of lipid GUVs in the presence of AzoTAB.…”

Section: Resultsmentioning

confidence: 99%

UV-Induced Bursting of Cell-Sized Multicomponent Lipid Vesicles in a Photosensitive Surfactant Solution

et al. 2012

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We study the behavior of multicomponent giant unilamellar vesicles (GUVs) in the presence of AzoTAB, a photosensitive surfactant. GUVs are made of an equimolar ratio of dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) and various amounts of cholesterol (Chol), where the lipid membrane shows a phase separation into a DPPC-rich liquid-ordered (Lo) phase and a DOPC-rich liquid-disordered (Ld) phase. We find that UV illumination at 365 nm for 1 s induces the bursting of a significant fraction of the GUV population. The percentage of UV-induced disrupted vesicles, called bursting rate (Yburst), increases with an increase in [AzoTAB] and depends on [Chol] in a non-monotonous manner. Yburst decreases when [Chol] increases from 0 to 10 mol % and then increases with a further increase in [Chol], which can be correlated with the phase composition of the membrane. We show that Yburst increases with the appearance of solid domains ([Chol] = 0) or with an increase in area fraction of Lo phase (with increasing [Chol] ≥ 10 mol %). Under our conditions (UV illumination at 365 nm for 1 s), maximal bursting efficiency (Yburst = 53%) is obtained for [AzoTAB] = 1 mM and [Chol] = 40 mol %. Finally, by restricting the illumination area, we demonstrate the first selective UV-induced bursting of individual target GUVs. These results show a new method to probe biomembrane mechanical properties using light as well as pave the way for novel strategies of light-induced drug delivery.

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Section: Resultsmentioning

confidence: 99%

UV-Induced Bursting of Cell-Sized Multicomponent Lipid Vesicles in a Photosensitive Surfactant Solution

et al. 2012

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“…When the light source was removed, the flow returned to laminar. This was a reversible process and the flow was successfully switched multiple times in the same experiment [125]. A recent study by Toyota et al [127] demonstrated an autonomous droplet which spontaneously moved once placed in an aqueous solution in which "fuel" surfactant had been dispersed.…”

Section: Figure 18 Photo-induced Confirmation Change Of Azotab Betwementioning

confidence: 96%

“…Recently it was demonstrated that the AzoTAB surfactant could be used to change the flow in a microfluidic system from laminar to segmented flow (droplets) [125]. Initially the system had a two-phase flow, one flow was aqueous (which contained the AzoTAB surfactant) and the second was an oil phase.…”

Section: Figure 18 Photo-induced Confirmation Change Of Azotab Betwementioning

confidence: 99%

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Dunne¹,

Francis²,

Delaney³

et al. 2017

Reference Module in Materials Science and Materials Engineering

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Integration of stimuli-responsive materials into microfluidic systems provides a means to locally manipulate flow at the microscale, in a non-invasive manner, while also reducing system complexity. In recent years, several modes of stimulation have been applied, including electrical, magnetic, light and temperature, among others. To achieve remote control of flow in microfluidics using external stimulation, two main approaches have emerged in the recent years: 1. Control of flow through stimuli-induced actuation of microfluidic components (valves, pumps, mixers, flow sorters), most often fabricated from soft polymeric materials; 2. Stimuli-controlled manipulation of discrete micrometer-sized "vehicles" (droplets, beads, Janus particles, etc.) through localized induced changes in wettability or surface tension.The focus of this chapter will be to identify and compare the similarities and underlying mechanisms employed in the current state of the art research in stimuli-controlled fluid control and micro-vehicle movement fields. It will also endeavor to propose possible directions for the evolution of these areas of research.

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“…In the large majority of cases, the drop motion is induced by an interfacial energy gradient at a solid/liquid interface (wettability gradient) and/or at a free interface (Marangoni stress) 3. This has resulted in a plethora of studies to elucidate the fundamental mechanisms that convert such gradients into drop motion4 as well as to develop strategies to manipulate drops under the control of various external signals, such as thermal,5 electrical2, 6, 7 and optical8, 9, 10, 11, 12, 13 stimuli. Most of these approaches necessitate the implementation of rather complex components, such as electrodes or optical elements, or the development of systems that are intrinsically responsive to the desired stimulus, such as photo‐ or thermosensitive substrates 8, 9.…”

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confidence: 99%

Magnetic Actuation of Drops and Liquid Marbles Using a Deformable Paramagnetic Liquid Substrate

et al. 2017

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The magnetic actuation of deposited drops has mainly relied on volume forces exerted on the liquid to be transported, which is poorly efficient with conventional diamagnetic liquids such as water and oil, unless magnetosensitive particles are added. Herein, we describe a new and additive‐free way to magnetically control the motion of discrete liquid entities. Our strategy consists of using a paramagnetic liquid as a deformable substrate to direct, using a magnet, the motion of various floating liquid entities, ranging from naked drops to liquid marbles. A broad variety of liquids, including diamagnetic (water, oil) and nonmagnetic ones, can be efficiently transported using the moderate magnetic field (ca. 50 mT) produced by a small permanent magnet. Complex trajectories can be achieved in a reliable manner and multiplexing potential is demonstrated through on‐demand drop fusion. Our paramagnetofluidic method advantageously works without any complex equipment or electric power, in phase with the necessary development of robust and low‐cost analytical and diagnostic fluidic devices.

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Photoreversible fragmentation of a liquid interface for micro-droplet generation by light actuation

Cited by 50 publications

References 35 publications

UV-Induced Bursting of Cell-Sized Multicomponent Lipid Vesicles in a Photosensitive Surfactant Solution

UV-Induced Bursting of Cell-Sized Multicomponent Lipid Vesicles in a Photosensitive Surfactant Solution

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Magnetic Actuation of Drops and Liquid Marbles Using a Deformable Paramagnetic Liquid Substrate

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