Photoresponsive Ru Metalloprodrug Assemblies: Red‐Light‐Controlled Self‐Delivery Systems for Enhanced Anticancer Phototherapy
Xiaolong Zeng,
Zongwei Zhang,
Yun‐Shuai Huang
et al.
Abstract:Small‐molecule ruthenium (Ru) complexes exhibit limitations in terms of nonspecific delivery, rapid metabolism, and low tumor accumulation. Their delivery can be improved through physical encapsulation into nanocarriers via hydrophobic forces, metallophilic interactions, or π–π stacking interactions. However, delivering Ru complexes for efficient therapy is substantially hindered by potential leakage of drugs, low drug‐loading capacity, or batch‐to‐batch variations. Moreover, current metalloprodrug‐based self‐… Show more
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