Photoresponsive polymers with multi-azobenzene groups

Sun, Shaodong; Liang, Shuofeng; Ye, Zijian; Xu, Guizhen; Wu, Si

doi:10.1039/c9py00793h

Cited by 91 publications

(64 citation statements)

References 142 publications

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“…Polymer nanoparticles, such as spiropyran-indoline-PEG nanoparticles, were also employed in chemotherapeutic docetaxel delivery. [212] UV irradiation induced the shrinkage of the nanoparticles from 103 to 49 nm, which enhanced tissue penetration, drug release and cancer therapy efficiency in nude mice. [213] In Figure 9.…”

Section: Polymer Nanoparticles For Photoisomerization Drug Delivery Smentioning

confidence: 99%

Light: A Magical Tool for Controlled Drug Delivery

Tao

Chan

Shi

et al. 2020

Adv Funct Materials

167

141

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Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application, and exquisite temporal and spatial control. Great progress is achieved in the development of novel light-driven drug delivery strategies with both breadth and depth. Light-controlled drug delivery platforms can be generally categorized into three groups: photochemical, photothermal, and photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, metal sulfides and oxides, metal-organic frameworks, carbon nanomaterials, upconversion nanoparticles, semiconductor nanoparticles, stimuli-responsive micelles, polymer-and liposome-based nanoparticles are applied for light-stimulated drug delivery. In view of the increasing interest in on-demand targeted drug delivery, the development of light-responsive systems with a focus on recent advances, key limitations, and future directions is reviewed.

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Section: Polymer Nanoparticles For Photoisomerization Drug Delivery Smentioning

confidence: 99%

Light: A Magical Tool for Controlled Drug Delivery

Tao

Chan

Shi

et al. 2020

Adv Funct Materials

167

141

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“…Note that most of the reported azobenzene-containing compounds have only non-conjugated AB units (mono-AB). The different AB derivatives can exist in Z-state for many hours in the dark [6,12]. At the same time, irradiation of photochromic components containing two (or more) AB units leads to a mixture of three isomers E/E, E/Z, and Z/Z at the photostationary state ( Figure 1b) [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Typically, the organic azo-based chromophores have been incorporated into a polymer backbone (via both covalent and noncovalent binding), the polyhedral oligomeric silsesquioxane core, and others silica-based particles that have better processability and optical properties (i.e. reduced chromophore aggregation) than small molecules [3,12,[16][17][18]. Importantly, that besides photoisomerization, the formation of surface relief gratings in the films, photoinduced orientation, photoactuation are also possible in AB-functionalized polymers [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of bis-azobenzene derivatives with reactive bromohexyl unit and carboxylic acid group based on Disperse Yellow 7

2020

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In this work, two types of azobenzene derivatives based on Disperse Yellow 7 (DY7, 4-[4-(phenylazo)phenylazo]-o-cresol) were synthesized, which are bis-azobenzenes bearing flexible functional 6-bromohexyl chain or carboxylic acid moiety. The first one was synthesized by alkylation of DY7 with an excess of 1,6-dibromohexane in the presence of a mild base (K2CO3). The second one (azo dye with carboxylic acid functionality) was obtained by the alkaline hydrolysis of the ester bond of the newly obtained DY7 derivative with the ethoxycarbonyl group. The synthesized compounds were characterized by different spectral analytical techniques such as 1H NMR, 13C NMR, FT-IR, and UV-Vis. They can be employed for the synthesis of a wide variety of azo-based materials, which may be suitable for photochromic systems and molecular electronics applications.

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“…[5][6][7] Other physical properties of the azobenzene moiety are affected as well, most notably its dipole moment: it increases or decreases upon photoisomerization, depending on the type and position of phenyl ring substituents. 8,9 Thus, photoisomerization of azobenzenes linked to a thermosensitive amphiphilic polymer affects the phase transition temperature of the polymer in water as a consequence of the different hydrophilicity of the cis and trans isomers. 10,11 For practical applications that require fast reversibility, it is advantageous to use azobenzenes that exhibit an extremely fast thermal cis to trans relaxation, so that a single UV light beam can induce continuous trans ↔ cis isomerizations.…”

Section: Introductionmentioning

confidence: 99%