Photoresponsive Polymer Films with Directly Micropatternable Surfaces Based on the Change in Free Volume by Photo‐Crosslinking (Adv. Mater. Interfaces 9/2022)

Noguchi, Takafumi; Akioka, Nobuhiro; Kojima, Yuri; Kawamura, Akifumi; Miyata, Takashi

doi:10.1002/admi.202270049

Cited by 1 publication

(3 citation statements)

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“…A small increase in fibronectin adsorption on the PCEMA‐ g‐ PDMS film upon UV exposure indicates that UV exposure might slightly enhance nonspecific protein adsorption ( p < 0.1). In our previous study, X‐ray photoelectron spectroscopy (XPS) and contact angle measurements revealed that the surface of PCEMA‐ g‐ PDMS films underwent no change in chemical properties, such as surface composition and hydrophilicity, upon UV exposure [37] . Therefore, fibronectin may recognize changes in the chemical properties of PCEMA‐ g‐ PDMS films due to UV exposure, which are too small to be detected via XPS and water contact angle measurements.…”

Section: Resultsmentioning

confidence: 98%

“…The synthesis of 2‐cinnamoyloxyethyl methacrylate (CEMA) and PCEMA‐ g‐ PDMS has been described in detail in a previous paper as shown in Scheme [37] . Successful synthesis was confirmed via proton nuclear magnetic resonance ( 1 H NMR, Figure ).…”

Section: Methodsmentioning

confidence: 99%

“…Typically, stimuli‐responsive changes in volume are observed in polymers swollen in solvents, such as hydrogels and organogels, because these changes result from the absorption and desorption of solvents. However, in our previous paper, we suggested that crosslinking could induce changes in the volume of polymer films despite the absence of a solvent [37] . Our facile fabrication technique enabled the formation of micropatterns using only ultraviolet (UV) light exposure through a photomask without development using solvents, which is based on decrease in the free volume of poly(dimethylsiloxane) (PDMS) induced by photocrosslinking.…”

Section: Introductionmentioning

confidence: 96%

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Cell patterning on photocrosslinkable polymer films with micropatternable surfaces

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Responsive Materials

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The regulation of cell behavior is crucial for understanding many fundamental biological processes and designing novel medical devices. Nano/micropatterning has been developed as a means of controlling cellular properties and behaviors. Using cinnamoyl groups that have undergone photodimerization, we have prepared facile photopatterning films with adjustable surface properties for cell patterning via simple steps. Our strategy for controlling surface properties uses the decrease in free volume induced by photocrosslinking. This paper describes the surface‐patterning properties of photocrosslinkable polymer films and the cell adhesion to their micropatterned surfaces. Upon culturing cells on micropatterned surfaces, preferential cell adhesion, alignment and proliferation are observed in the unexposed regions. Additionally, diverse surface patterns of photocrosslinkable polymer films have been fabricated using various photomasks, enabling effective control of cell adhesion and alignment. The ability to regulate cellular behavior via microfabricated surfaces of photocrosslinkable polymer films enables a new and facile approach for designing scaffolds for the development of novel advanced materials, tissue engineering, and regenerative medicine.