Photoresponsive Materials for Antibacterial Applications

Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes, in contrast to conventional chemotherapeutic drugs, which act on precise targets such as DNA or specific enzymes. Owing to their rapid action, broad-spectrum activity, and mechanisms of action that potentially hinder the development of resistance, MDPs have been increasingly considered as future therapeutics in the drug-resistant era. Recently, growing experimental evidence has demonstrated that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents. In this review, we evaluate the literature around the broad-spectrum antimicrobial properties and anticancer activity of MDPs, and summarize the current development and mechanisms of MDPs alone or in combination with other agents. Notably, this review highlights recent advances in the design of various MDP-based drug delivery systems that can improve the therapeutic effect of MDPs, minimize side effects, and promote the co-delivery of multiple chemotherapeutics, for more efficient antimicrobial and anticancer therapy.

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“…, TiO 2 and ZnO, Fig. 10 A) 183 , 184 , 185 . As seen in the photoresponsive mechanisms shown in Fig.…”

Section: Multi-drug Combination Therapymentioning

confidence: 99%

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Lin

Chi

Yan

et al. 2021

Acta Pharmaceutica Sinica B

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“…Various PANs such as zinc-based nanomaterials ( Li et al, 2019a ), silver-based nanomaterials ( Zhu et al, 2020 ), gold-based nanomaterials ( Li X. et al, 2020 ), metal organic frameworks (MOFs) ( Luo et al, 2021 ), copper-based nanomaterials ( Han et al, 2021 ), and graphene-based nanomaterials ( Lv et al, 2021 ) exhibiting photothermal activity have been investigated to combat drug resistant bacteria ( Ren et al, 2020 ). Due to their structural compositions and chemical nature, MOFs are considered the front-runner antibacterial PANs ( Zheng et al, 2021 ).…”

Section: Photothermally Active Nanomaterials As Potent Antibacterial Agentsmentioning

confidence: 99%

Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review

et al. 2021

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Injudicious use of antibiotics has been the main driver of severe bacterial non-susceptibility to commonly available antibiotics (known as drug resistance or antimicrobial resistance), a global threat to human health and healthcare. There is an increase in the incidence and levels of resistance to antibacterial drugs not only in nosocomial settings but also in community ones. The drying pipeline of new and effective antibiotics has further worsened the situation and is leading to a potentially “post-antibiotic era.” This requires novel and effective therapies and therapeutic agents for combating drug-resistant pathogenic microbes. Nanomaterials are emerging as potent antimicrobial agents with both bactericidal and potentiating effects reported against drug-resistant microbes. Among them, the photothermally active nanomaterials (PANs) are gaining attention for their broad-spectrum antibacterial potencies driven mainly by the photothermal effect, which is characterized by the conversion of absorbed photon energy into heat energy by the PANs. The current review capitalizes on the importance of using PANs as an effective approach for overcoming bacterial resistance to drugs. Various PANs leveraging broad-spectrum therapeutic antibacterial (both bactericidal and synergistic) potentials against drug-resistant pathogens have been discussed. The review also provides deeper mechanistic insights into the mechanisms of the action of PANs against a variety of drug-resistant pathogens with a critical evaluation of efflux pumps, cell membrane permeability, biofilm, and quorum sensing inhibition. We also discuss the use of PANs as drug carriers. This review also discusses possible cytotoxicities related to the therapeutic use of PANs and effective strategies to overcome this. Recent developments, success stories, challenges, and prospects are also presented.

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“…As a relatively inexpensive and convenient external stimulus, light is extensively used for controllable drug release from responsive nanocarriers with high spatial and temporal precision [ 64 ]. Particularly, light in near-infrared (NIR) region is suitable for treatment of biofilm infections as the longer wavelength has deeper tissue penetration and almost negligible harm to living organisms.…”

Section: Nanocarriers Responsive To External Stimulimentioning

confidence: 99%

Stimuli-responsive nanocarriers for bacterial biofilm treatment

et al. 2021

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Bacterial biofilm infections have been threatening the human’s life and health globally for a long time because they typically cause chronic and persistent infections. Traditional antibiotic therapies can hardly eradicate biofilms in many cases, as biofilms always form a robust fortress for pathogens inside, inhibiting the penetration of drugs. To address the issues, many novel drug carriers emerged as promising strategies for biofilm treatment. Among them, stimuli-responsive nanocarriers have attracted much attentions for their intriguing physicochemical properties, such as tunable size, shape and surface chemistry, especially smart drug release characteristic. Based on the microenvironmental difference between biofilm infection sites and normal tissue, many stimuli, such as bacterial products accumulating in biofilms (enzymes, glutathione, etc.), lower pH and higher H 2 O 2 levels, have been employed and proved in favor of “on-demand” drug release for biofilm elimination. Additionally, external stimuli including light, heat, microwave and magnetic fields are also able to control the drug releasing behavior artificially. In this review, we summarized recent advances in stimuli-responsive nanocarriers for combating biofilm infections, and mainly, focusing on the different stimuli that trigger the drug release. 摘要细菌生物膜常造成长期, 顽固的感染, 因此长久以来都严重威胁着全球人类的生命健康。由于生物膜会为内部病原体建造其保护性屏障, 阻碍药物的渗透, 因此传统的抗生素疗法通常难以根除生物膜。为了解决这一问题, 研究人员构建了许多新型的药物载体, 以作为颇具前景的生物膜治疗策略。其中, 刺激响应型纳米载体具有有趣的物理-化学性质, 例如尺寸, 形状和表面化学可调节的性质, 特别是智能药物释放性质, 因此吸引了人们的广泛关注。根据生物膜感染位置和正常组织之间的微环境差异, 人们利用多种刺激物, 比如生物膜内积累的细菌产物 (酶, 谷胱甘肽等), 低pH和高H 2 O 2 水平, 来设计药物的“按需释放”以清除生物膜。此外, 包括光, 热, 微波和磁场在内的外源刺激, 也可以用于人工控制药物的释放行为。本篇综述中, 我们总结了刺激响应型纳米载体在对抗细菌生物膜中的最新进展, 并着重于引发药物释放的多种刺激物。 Graphic abstract

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Photoresponsive Materials for Antibacterial Applications

Cited by 119 publications

References 127 publications

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review

Stimuli-responsive nanocarriers for bacterial biofilm treatment

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