Photoresponsive Coumarin‐Based Supramolecular Hydrogel for Controllable Dye Release

materials with diverse applications in var ious fields due to their tunable chemistry structure and physical properties as well as excellent biocompatibility. [2][3][4][5] Hydrogel research has evolved from static mate rials to smart ones, whose structures and property show responsiveness to external stimuli, including temperature, pH, light, electric or magnetic fields, and the pres ence of enzymes or ion concentrations. [6][7][8][9][10][11] This unprecedented level of control over material properties has driven both med ical and industrial fields into the realm of possibility: controlled drug delivery, [12] chemical sensors, [13] soft actuators or robotics, [14][15][16] or scaffolds for dynamic 3D cell culture. [17] Photoresponsiveness is attractive due to the inherent advan tages of light as stimulus. Light is non invasive and allows remote manipulation of materials without requiring additional reagents, thus, with limited byproducts. Modulation of irradiation parameters, such as light intensity and irradiation time, permits the pre cise control of irradiation dosage, thereby, the degree of photo reactions. Spatial control can be achieved in both 2D and 3D, and temporal control is possible by simply turning the respec tive light source on or off. Wavelengthselective photo chemical reactions can be used for orthogonal photomediation of hydrogel properties. [18] Photoresponsive hydrogels, as externally tunable materials, strongly contribute to the field of soft smart materials in regard to the abovementioned applications. [19] In this review, we elaborate on the design and the emerging appli cations of photoresponsive hydrogels. A comprehensive review about utilizing light for the formation of hydrogels is given by Mi and coworkers. [20] First, we discuss responsive modes and photochemical mechanisms of photoresponsive hydrogels. Fol lowing this, we highlight their applications for dynamic cell environments, smart biointerfaces, controlled drug delivery, photodriven actuators, and lighthealing materials. The review concludes with an outlook on the challenges and potential future approaches for photo responsive hydrogels. Light as Stimulus for Hydrogels Macroscopic Hydrogel PhotoresponsesThe interaction of light with photoresponsive hydrogels can result in different responses, some of which are observable with the bare eye. Those include hydrogel formation or degradation, network contraction or expansion, and chemical modifications in the network, which then have an immediate consequence on Hydrogels are the most relevant biochemical scaffold due to their tunable properties, inherent biocompatibility, and similarity with tissue and cell environments. Over the past decade, hydrogels have developed from static materials to "smart" responsive materials adapting to various stimuli, such as pH, temperature, chemical, electrical, or light. Light stimulation is particularly interesting for many applications because of the capability of contact-free remote manipulation of biomaterial properties and inherent spatial and t...

show abstract

“…Due to their orthogonality with many functional groups, electrocyclic reactions, such as [47] coumarins, [48,49] Adv. Mater.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

“…Both cycloadditions can be reversed upon exposure to light at suitable wavelength or via heating. Representative exam ples are [2+2]cycloaddition of cinnamates, [47] coumarins, [48,49] Adv. Mater.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

Design and Applications of Photoresponsive Hydrogels

2019

View full text Add to dashboard Cite

show abstract

“…Other works deal with constructing hyperbranched polymer-based light-harvesting structure with coumarin derivatives as the donor and acceptor chromophores [76]. Similarly, photochemical properties provide polymeric materials with controlled drug-delivery capabilities from a coumarin-based phototriggering effect [77][78][79]. These polymers include also light-sensitive polypeptides for controlled structure and properties by light [80].…”

Section: Coumarins Into Polymersmentioning

confidence: 99%

Coumarins into Polyurethanes for Smart and Functional Materials

et al. 2020

View full text Add to dashboard Cite

Polyurethanes are of undoubted interest for the scientific community and the industry. Their outstanding versatility from tailor-made structures turns them into major polymers for use in a wide range of different applications. As with other polymers, new, emerging molecules and monomers with specific attributes can provide new functions and capabilities to polyurethanes. Natural and synthetic coumarin and its derivatives are characterised by interesting biological, photophysical and photochemical properties. Then, the polyurethanes can exploit those features of many coumarins which are present in their composition to achieve new functions and performances. This article reviews the developments in the proper use of the special properties of coumarins in polyurethanes to produce functional and smart materials that can be suitable for new specific applications.

show abstract

“…Another widely used physical stimulus is light, which leverages hydrogelators encoded with light‐sensitive groups (e.g., photocleavable groups, photoisomerizable groups) to trigger phase transitions . One key advantage of light as a trigger is the potential use of coherent light sources such as laser, which allows creation of supramolecular hydrogels with high spatial resolution .…”

Section: Physical Stimuli‐responsive Hydrogelsmentioning

confidence: 99%

Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

Hoque

Sangaj

Varghese

2018

Macromolecular Bioscience

144

108

View full text Add to dashboard Cite

Supramolecular hydrogels are a class of self-assembled network structures formed via non-covalent interactions of the hydrogelators. These hydrogels capable of responding to external stimuli are considered to be smart materials due to their ability to undergo sol–gel and/or gel–sol transition upon subtle changes in their surroundings. Such stimuli-responsive hydrogels are intriguing biomaterials with applications in tissue engineering, delivery of cells and drugs, modulating tissue environment to promote innate tissue repair, and imaging for medical diagnostics among others. This review summarizes the recent developments in stimuli-responsive supramolecular hydrogels and their potential applications in regenerative medicine. Specifically, various structural aspects of supramolecular hydrogelators involved in self-assembly, the role of external stimuli in tuning/controlling their phase transitions, and how these functions could be harnessed to advance applications in regenerative medicine are focused on. Finally, the key challenges and future prospects for these versatile materials are briefly described.

show abstract

Photoresponsive Coumarin‐Based Supramolecular Hydrogel for Controllable Dye Release

Cited by 23 publications

References 67 publications

Design and Applications of Photoresponsive Hydrogels

Design and Applications of Photoresponsive Hydrogels

Coumarins into Polyurethanes for Smart and Functional Materials

Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

Contact Info

Product

Resources

About