Photorejuvenation by Intense Pulsed Light with Objective Measurement of Skin Color in Japanese Patients

Abstract

IPL skin rejuvenation using relatively shorter wavelengths and pulse widths brought about significant macroscopic and quantitative improvements, especially in the treatment of epidermal pigmentation and improvement of basic skin tone.

Effects of Intense Pulsed Light on the Biological Properties and Ultrastructure of Skin Dermal Fibroblasts: Potential Roles in Photoaging

“…8,10 Fibroblasts, the major cellular components in skin dermis, are the key cells responsible for the biosynthesis of extracellular matrix (ECM) proteins. 11 The effects of IPL on skin fibroblast activity remain unknown.…”

“…Rough endoplasmic reticula, polyribosomes, and Golgi of fibroblasts, which were the main sites to synthesize proteins, were abundant in the IPL irradiation group, suggesting that these organelles were well prepared for the formation of new collagen. Previous studies have demonstrated a histological increase in collagen types I and III in the dermal extracellular matrix after IPL treatment, 10,17 so this study could explain subcellular structure of the photorejuvenation effects of IPL.…”

“…Likewise, Goldman et al demonstrated that IPL treatment may lead to increased transcription of type I collagen, and increased collagen (types I and III) and elastin in patients. 6 Negishi et al 10 demonstrated that histological analysis of skin biopsies from IPL-treated patients showed increased staining of type I and type III collagen. The study reported herein together with the previous clinical studies demonstrating increased collagen deposition after IPL treatment provides a foundation for understanding the mechanisms that lead to clinical improvement.…”

Intense pulsed light modulates the expressions of MMP-2, MMP-14 and TIMP-2 in skin dermal fibroblasts cultured within contracted collagen lattices

“…Studies of IPL effects on photoaged skin revealed clinical improvement of wrinkles, pigmentation and telangiectasias [5]. Various hypotheses have been presented to explain the potential mechanisms of IPL effects.…”

Non‐Ablative Resurfacing

“…Since this is an expected occurrence, patients should be appropriately forewarned to prevent unnecessary distress. More prolonged dyschromia, including hypoand hyperpigmentation, may be seen in up to 15% of patients, especially those with darker skin tones, a suntan, or melasma within the treatment area [27]. Such dyschromia usually lasts less than 2 months, and its incidence may be reduced -though likely not entirely eliminated -by following the above-mentioned guidelines regarding various device settings.…”