Photorefractive Keratectomy in High Myopic Defects with or without Intraoperative Mitomycin C: 1-Year Results

Abstract

In this study, the application of MMC 0.02% solution immediately after PRK produced lower haze rates and had better predictability and improved efficacy 1 year after treatment.

Visual outcomes after wavefront-guided photorefractive keratectomy and wavefront-guided laser in situ keratomileusis: Prospective comparison

“…In contrast to the Wallau and Campos study, in which MMC was used in all cases, we administered MMC only to PRK ablations deeper than 65 mm (17 of 101 PRK eyes). Although some studies 16,17 report changes in refractive outcome predictability with the use of MMC in PRK, the results remain controversial. We did not stratify MMC cases in our analysis; therefore, we cannot support or dispute the finding that routine use of MMC leads to improved visual outcomes in wavefront-guided PRK.…”

Creation of an extremely thin flap using IntraLase femtosecond laser

“…9,10 Although there are many reports that surface ablation with low dose mitomycin-C (MMC) can reduce postoperative haze in high myopia, the long-term safety of MMC has not been established. 11,12 Another choice was LASIK surgery with a microkeratome or IntraLase laser. The disadvantage of using a microkeratome (160 mm head; Hansatome [Bausch & Lomb] in our hospital) was that the remaining residual stromal thickness was less than 250 mm after full correction in this patient.…”

Corneal endothelial cell injury induced by mitomycin-C in photorefractive keratectomy: Nonrandomized controlled trial

“…Furthermore, based on experimental studies suggesting the efficacy of MMC in minimizing subepithelial corneal haze formation, 13,14 intraoperative use of topical MMC during PRK has been evaluated over the past few years. [15][16][17][18][19][20] Inhibition of proliferation of human keratocytes and induction of keratocyte and myofibroblast apoptosis are suggested mechanisms for the success of MMC in preventing corneal haze. [21][22][23][24][25][26] Nevertheless, side effects, including corneal endothelial toxicity, have been reported after ophthalmic use and in in vitro experiments using MMC.…”