Photoredox-Catalyzed Sequential Decarboxylative/Defluorinative Aminoalkylation of CF₃-Alkenes with N-Arylglycines

Abstract

A photoredox-catalyzed sequential decarboxylative/ defluorinative aminoalkylation of CF 3 -alkenes with N-arylglycines is described. This metal-free and redox-neutral protocol provided efficient access to the monofluoroalkenyl-1,5-diamines in good yields with excellent functional group compatibility. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the gem-difluoroalkenyl amine as an intermediate.