Photoredox-catalysed hydroaminoalkylation of on-DNA N-arylamines

Abstract

An efficient approach to the photoredox-catalysed hydroaminoalkylation between on-DNA secondary N-substituted (hetero)arylamines and vinylarenes has been developed and explored. The methodology was examined with a broad scope of vinylarenes and...

Synthesis of Diacylhydrazine Derivatives Based on Tetrazole-Focused DNA-Encoded Library

“…Given that the chemical space and structural diversity of DEL are pivotal in the binder selection process, considerable efforts have been directed toward constructing diverse libraries, each emphasizing a specific structural motif. However, such existing libraries remain confined to pharmacologically relevant chemical spaces, constrained by library design .…”

sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

“…[6c,8] Consequently, there is continued interest in expanding the scope of DNA-compatible chemical reactions. [4b,9] Towards this goal, recent successes in multicomponent, [10] photocatalysis, [11] cycloaddition [12] and sp 2 -sp 3 crosscoupling [13] reactions on DNA, among others [9] have created new opportunities for DEL synthesis. For example, researchers at Pfizer have demonstrated that C(sp 3 )À H activation can be realized on DNA to merge small rings with heterocycles (Figure 1C).…”