Photoreactivity and cell adhesiveness of amino-group-modified titanium dioxide nano-particles on silicone substrate coated by covalent linkage

Furuzono, Tsutomu; Iwasaki, Mitsunobu; Yasuda, Shoji; Korematsu, Arata; Yoshioka, Tomohiko; Kishida, Akio

doi:10.1023/b:jmsl.0000005408.57803.fc

Cited by 10 publications

(9 citation statements)

References 3 publications

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“…In the spectrum of the TiO 2 after modification with γ‐APS [amino group density, 3.0 molecules/nm 2 ; Fig. 4(b)], the intensity of the band at 3692 cm −1 , attributed to the bridge‐OH terminal groups of TiO 2 , decreased, which corresponded to that reported in the previous article,13 indicating the reaction of the OH groups with the silane coupling agent. An additional peak is present with respect to the original TiO 2 spectrum at 2928 cm −1 , indicating CH stretching of the organic compound.…”

Section: Resultssupporting

confidence: 80%

“…The photoreactivity of the modified TiO 2 was evaluated by the degradation rate of CH 3 CHO. In the previous article,13 although the anatase phase of the TiO 2 particles did not change after the reaction between the silane coupling agent and the OH groups on the outermost surface of the particle, the photoreactivity became approximately 30 times lower than that of the original TiO 2 , which should be due to high coverage of the TiO 2 surface by silane coupling agents. The high coverage in the previous study should be due to crosslinking reactions among the silane coupling agents at a higher reaction temperature (120°C) than that of this study (30°C).…”

Section: Resultsmentioning

confidence: 77%

“…The TiO 2 particles were chemically modified with an amino group‐terminated silane coupling agent at 30°C for different reaction time. In the previous article,13 modification with amino groups was confirmed by FT‐IR. Figure 2 shows the density of amino groups on the surfaces of the TiO 2 particles after modification at 30°C for different reaction times.…”

Section: Resultsmentioning

confidence: 81%

“…Actually, the novel composite showed good tissue adhesiveness in animal implant tests 12. Furthermore, in a previous article,13 we tried to incorporate two functions, that is, bioactivity and photoreactivity, into a percutaneous device by using TiO 2 particles. Such a system is expected to prevent damage by the antibacterial activity of photoexcited TiO 2 when a germ infection unfortunately occurs after implantation.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities

Okada

Yasuda

Kimura

et al. 2005

J Biomedical Materials Res

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A composite consisting of titanium dioxide (TiO2) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the TiO2 particle surface was controlled by the reaction time of the modification reaction. The degradation rate of CH3CHO in the presence of the TiO2 particles under UV irradiation decreased with an increase in the amino group density on the TiO2 surface. On the other hand, the number of L929 cells adhering on the TiO2/silicone composite increased with an increase in the amino group density. From the above two results, the optimum density of amino groups for both photoreactivity and cell adhesiveness was estimated to be 2.0-4.0 molecules/nm2. The optimum amino group-modified TiO2/silicone composite sheet (amino group density, 3.0 molecules/nm2) showed an effective antibacterial activity for Escherichia coli bacteria under UV irradiation.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities

Okada

Yasuda

Kimura

et al. 2005

J Biomedical Materials Res

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show abstract

“…Presently, nano-TiO 2 has been used as one of the most useful and well-studied photocatalytic materials due to its strong oxidizing activity [18,19]. Since nano-TiO 2 is chemically stable and relatively nontoxic, it is environment friendly [18,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

The in vitro inhibition of multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition

Song¹,

Zhang²,

Dai³

et al. 2006

Biomaterials

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Nano-scaled hydroxyapatite/polymer composite IV. Fabrication and cell adhesion properties of a three-dimensional scaffold made of composite material with a silk fibroin substrate to develop a percutaneous device

et al. 2004

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Nano-scaled sintered hydroxyapatite (HAp) particles with an a-axis length of 87 +/- 23 nm, a c-axis length of 236 +/- 81 nm, and a mean aspect ratio ( c/ a) of 2.72 were covalently linked onto a silk fibroin (SF) substrate chemically modified by graft polymerization with gamma-methacryloxypropyl trimethoxysilane (MPTS). Graft polymerization with poly(MPTS) on SF was conducted by free-radical initiation in a water solvent with pentaethylene glycol dodecyl ether as a nonionic surfactant. The alkoxysilyl groups of the graft polymers avoided hydrolysis and maintained their activity in coupling with the hydroxyl groups on the HAp surface despite the use of water as the reaction solvent. The weight gain of poly(MPTS) on SF increased with increasing the reaction time, eventually reaching a plateau value of about 15 wt% after 50 min of reaction time. After HAp covalent coating, the particles separated or aggregated into several crystals, as shown by scanning electron microscopic observation. L929 fibroblast cells adhered more plentifully on HAp-coated SF compared to untreated SF and hydrolyzed poly(MPTS)-grafted SF during 24 h or 48 h of incubation. The cells adhered only on the HAp surface but not at all on the dehydrated grafted surface of SF without HAp. A button-shaped prototype for a percutaneous device was manufactured by transplantation of HAp-coated SF fibers of about 100 microm in length onto silicone moldings using an adhesive, and the device showed good cell adhesiveness.

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Photoreactivity and cell adhesiveness of amino-group-modified titanium dioxide nano-particles on silicone substrate coated by covalent linkage

Cited by 10 publications

References 3 publications

Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities

Optimization of amino group density on surfaces of titanium dioxide nanoparticles covalently bonded to a silicone substrate for antibacterial and cell adhesion activities

The in vitro inhibition of multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition

Nano-scaled hydroxyapatite/polymer composite IV. Fabrication and cell adhesion properties of a three-dimensional scaffold made of composite material with a silk fibroin substrate to develop a percutaneous device

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