Photoradiation therapy: Current status and applications in the treatment of brain tumors

Cheng, Ming; McKean, John; Boisvert, Donald; Tulip, J.

doi:10.1016/0090-3019(86)90080-7

Cited by 46 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic resonance imaging (MRI), pathologic, and and Samaras, 1983;Cheng et al, 1986;Gutin et al, 1987; Koclinical signs of toxicity correlated roughly with increasing mbUtii and WaUcer, 1988;Shapko et al, 1989;Leibel et al, dose, with the highest doses producing significant histopatho-1994). Gene ttansfer potentially provides a new modaUty for tiie logic lesions with mimmal clinical signs of toxicity.…”

Section: Introductionmentioning

confidence: 97%

Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory Response

Smith¹,

Raper²,

Wheeldon³

et al. 1997

Human Gene Therapy

View full text Add to dashboard Cite

Replication-defective adenovirus expressing the herpes simplex thymidine kinase gene (H5.010RSVtk) may be useful in treating human gliomas. To determine the toxicity of this therapeutic strategy, we injected H5.010RSVtk stereotactically into the normal brain of Wistar rats, cotton rats, and rhesus monkeys in conjunction with systemic ganciclovir (GCV) at 10 mg/kg per day. In the Wistar rat, 5.7 x 10(9) pfu resulted in histopathologic injury consisting of localized necrosis, mild gliosis, marked malacia, and focal astrocytosis; however, 1.0 x 10(8) pfu resulted in only mild gliosis and trace meningitis and approximates a "no toxic effect" dose. A dose of 1.0 x 10(9) pfu in both adenoviral immune and adenoviral naive cotton rats resulted in similar findings. In the rhesus monkey, doses ranging from 1.4 x 10(8) pfu to 1.5 x 10(11) pfu resulted in localized gliosis, necrosis, perivascular cuffing, meningitis, and roughly correlated in severity with increasing dose. No histologic evidence of toxicity was found in non-central nervous system (CNS) tissues, and no virus could be cultured from cerebrospinal fluid (CSF), blood, urine, and stool samples. All animals survived to prescribed end points without signs of general toxicity or neurologic symptoms, except for 2 of the rhesus monkeys, one of which became febrile and the other of which developed a grand mal seizure (both subsequently resolved). These toxicology studies define the parameters for developing a phase I clinical trial.

show abstract

Section: Introductionmentioning

confidence: 97%

Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory Response

Smith¹,

Raper²,

Wheeldon³

et al. 1997

Human Gene Therapy

View full text Add to dashboard Cite

show abstract

“…Second, even if the BBB can be circumvented, for example, by employing implantable polymer wafers impregnated with drugs, selective uptake may not occur due to decreased proliferation rates of migrating glioma cells [4]. This characteristic, in combination with their reduced ability to undergo apoptosis, would presumably make these cells resistant, not only to chemotherapeutic agents, but also to ionizing radiation and would explain the disappointing results obtained with aggressive focal treatments including brachytherapy [5,6] and the selective delivery of chemotherapeutic agents or radiation [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy of newly implanted glioma cells in the rat brain

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Even with the best available treatments using surgery, chemotherapy and radiation therapy, median survival is only 9 to 12 months [3][4][5] . Several studies indicate that photodynamic therapy (PDT) may prove useful in prolonging survival and/or improving the quality-of-life in glioma patients [6][7][8][9][10][11] . PDT is a local form of treatment involving the administration of a tumor-localizing photosensitizing drug that is activated by light 12 .…”

Section: Introductionmentioning

confidence: 99%

Interstitial light application for photodynamic therapy in a rat brain tumor model

Angell-Petersen

Sørensen²,

Madsen

et al. 2004

SPIE Proceedings

View full text Add to dashboard Cite

The usefulness of repetitive ALA mediated PDT is being evaluated in a rat brain tumor model. In preliminary experiments an optical fiber was repeatedly introduced directly into the brain to apply light, requiring multiple surgical procedures. In an attempt to refine the animal model, an indwelling light applicator, using a modified microdialysis guide cannula has been developed. The cannula is fixed to the scull and can remain in the rat brain for several weeks without complications. In studies of repetitive PDT the need for repeated mounting in a stereotactic frame and surgical procedures can be eliminated. The applicator also makes it feasible to employ low fluence rates with long treatment times, which correspond to future clinically relevant protocols. The fluence rate distribution was measured in vivo and compared to diffusion theory and Monte Carlo simulations to estimate the tissue optical properties of the rat brain for light at 632 nm. The modeling suggested a reduced scattering coefficient 38 cm -1 , an absorption coefficient 0.46 cm -1 and a penetration depth 0.14 cm.

show abstract

Photoradiation therapy: Current status and applications in the treatment of brain tumors

Cited by 46 publications

References 38 publications

Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory Response

Intracranial Administration of Adenovirus Expressing HSV-TK in Combination with Ganciclovir Produces a Dose-Dependent, Self-Limiting Inflammatory Response

Photodynamic therapy of newly implanted glioma cells in the rat brain

Interstitial light application for photodynamic therapy in a rat brain tumor model

Contact Info

Product

Resources

About