Photoradiation Therapy — Clinical and Drug Advances

Dougherty, Thomas J.; Boyle, D. G.; Weishaupt, Kenneth R.; Henderson, Barbara W.; Potter, William R.; Bellnier, David A.; Wityk, K. E.

doi:10.1007/978-1-4684-4406-3_2

Cited by 103 publications

(36 citation statements)

References 2 publications

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“…after alkali treatment, see Materials and methods) contains at least 4 defined porphyrins (haematoporphyrin (Hp), two isomers of monohydroxy-monovinyldeuteroporphyrin (HvD) and protoporphyrin (PP)) (Bonnett et al, 1980;Moan & Sommer 1981). In addition to these compounds, a certain amount of unknown material is found, somewhat dependent on the method used to separate the components (Moan et al, , 1982aBerenbaum et al, 1982;Dougherty et al, 1983). A large fraction of these unknown components are aggregates, some of which may be composed of porphyrins bound strongly together with, for instance, covalent bonds (Moan et al, 1982a, Berenbaum et al, 1982.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting product was dissolved to a concentration of 6.25mgml-P and stirred for 1h at room temperature in 0.1N NaOH. Such treatment leads to hydrolysis of the acetates and the resulting mixture of porphyrins is termed HpD in accordance with Dougherty et al (1983).…”

Section: Chemicalsmentioning

confidence: 99%

“…An essential contribution to this progress has been the development of systems for chemical analysis of the HpD (Bonnett et al, 1980, Moan et al, 1982aKessel, 1982;Dougherty et al, 1983). This has resulted in an improved drug, the purified porphyrin aggregates normally constituting -40% of HpD .…”

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confidence: 99%

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Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin

Christensen¹,

Sandquist²,

Feren³

et al. 1983

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Chemicalsmentioning

confidence: 99%

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Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin

Christensen¹,

Sandquist²,

Feren³

et al. 1983

Br J Cancer

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“…The sensitization seen using this sensitizer may be due to hydrophobic contaminants (Kessel, 1982). Thus it is not surprising that it is the more hydrophobic components of the tumor photosensitizer preparation, hematoporphyrin derivative (Lipson et a/., 1961), which are responsible for photosensitized cell killing (Moan and Sommer, 1984;Dougherty et al, 1983).…”

Section: Membrane-photosensitizer Interactionsmentioning

confidence: 99%

Photomodification of Biological Membranes With Emphasis on Singlet Oxygen Mechanisms

Valenzeno

1987

Photochem & Photobiology

263

118

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Abstract-This review discusses photomodification of biological membranes and model membrane systems. Current concepts of membrane structure are first reviewed briefly. The role of preillumination association of sensitizer with membranes as it relates to photomodification rate is discussed, as well as the role of singlet oxygen in membrane photomodification. Finally the characteristics of singlet oxygen generation in membranes are considered. The evidence clearly indicates that membrane photomodification cannot be understood based only on the properties of sensitizers and singlet oxygen in aqueous solution. Rather the properties of sensitizers in association with membranes are the determinants of membrane photomodification. These properties differ significantly in aqueous solution and in membranes.

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“…Furthermore, because of its characteristic red fluorescence and its preferential localization in tumor tissue, it may be used as an aid in cancer diagnosis [3,4]. Hpd is a mixture of several porphyrins and it seems that the least polar of these are the most potent tumor localizers [5,6].…”

Section: Introductionmentioning

confidence: 99%

Formation of metal complexes of tumor‐localizing porphyrins

1984

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Whereas the tumor localizer and photosensitizer hematoporphyrin derivative (Hpd) has its fluorescence emission maximum at 610-630nm, several authors have reported that in aqueous solutions of hematoporphyrin (Hp) and Hpd, or in tumors after an injection of Hpd, a compound is formed which has its fluorescence emission maximum at 570-590nm.This work (HPLC and fluorescence analysis) indicates that this peak is due to the formation of Zn-porphyrins either in vitro or in vivo. Cu-and Co-porphyrins may be formed as well, from traces of these metallic ions. In contrast to free porphyrins and Zn-porphyrins the latter complexes are non-fluorescent and do not act as photosensitizers. Metalloporphyrin Tumor localizer Fluorescence Photosensitizer ChromatographyPhotochemotherapy

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Photoradiation Therapy — Clinical and Drug Advances

Cited by 103 publications

References 2 publications

Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin

Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin

Photomodification of Biological Membranes With Emphasis on Singlet Oxygen Mechanisms

Formation of metal complexes of tumor‐localizing porphyrins

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