Photoprotective and toxicological activities of extracts from the Antarctic moss Sanionia uncinata

Fernandes, Andréia da Silva; Alencar, Alexandre Santos de; Evangelista, Heitor; Mazzei, José Luiz; Felzenszwalb, Israel

doi:10.4103/0973-1296.149701

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…Several authors performed the in vitro SPF determination of formulations added with plant species extracts, such as Fernandes et al . (41) analyzed the photoprotective of the aqueous extract from Antarctic moss Sanionia uncinata , and obtained an SPF of 1.10 ± 0.23. Camones et al .…”

Section: Resultsmentioning

confidence: 99%

“…The preparation of sunscreens based exclusively on natural extracts must contain very high concentrations of such active substances to obtain the desired photoprotection; however, several studies have shown that the advantage of using these compounds in photoprotective formulations is due to the synergistic effect they produce when associated with organic filters. All the studies mentioned above had an increase in SPF by incorporating extracts with chemical filters, the aqueous extract from Antarctic moss Sanionia uncinata , demonstrated an increase in SPF from 11 (chemical filter only) to 14.7 (chemical filter with extract) (41). For the study with grape pomace was observed an increase in FPS from 14 to 76 (42), and for the ethanolic extract of Nephelium lappaceum , the SPF increase was from 11.2 to 26.3 (44).…”

Section: Resultsmentioning

confidence: 99%

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Hydroalcoholic Extract of Encholirium spectabile Mart. (Bromeliaceae) in O/W Emulsions as an Additive against the UVB Radiation

Dantas

Lira

Dutra

et al. 2022

Photochem & Photobiology

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The use of sunscreen is one of the photoprotection measures most used by the population, so these products must offer broad-spectrum protection against UVA and UVB radiation. Encholirium spectabile, popularly known as "macambira-deflecha," is a species characterized by its rocky outcrops and found in the Caatinga. This biome is known for extreme droughts and dry periods, and for this reason, its vegetation needed to develop resistance mechanisms. The aim of this work was to evaluate the use of E. spectabile incorporated in O/W emulsion as a potential photoprotective agent and their antioxidant activity. Four chemical constituents (ferulic acid, caffeic acid, p-coumaric acid and apigenin) were identified by HPLC-DAD analysis, and emulsions containing different concentrations (1%, 2.5% and 5%) of the extract without and with the addition of chemical filters (octyl methoxycinnamate and benzophenone-3) were prepared and submitted to the test of preliminary stability. The Q formulation demonstrated little variation in the preliminary stability test and was selected for estimated your protection against UVB and determination of in vitro protection factor UVA. The formulations remained stable during the freeze-thaw cycle; the extract despite maintaining the UVA-PF and decreasing the wavelength showed an increase in FPS from 14.4 (control) to 18.8 (control+ Es-HA80).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hydroalcoholic Extract of Encholirium spectabile Mart. (Bromeliaceae) in O/W Emulsions as an Additive against the UVB Radiation

Dantas

Lira

Dutra

et al. 2022

Photochem & Photobiology

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“…We have also demonstrated positive correlation between protective effect against UVR and phenolic compound present in extracts. Water-extractable compounds seem to contribute on photoprotection of this Antarctic moss [10, 13, 14]. Given the above context, the goal of this paper is to explore the potential photoprotective, cytotoxic and embryotoxic effects of residual AF from the polar moss S. uncinata .…”

Section: Discussionmentioning

confidence: 99%

“…Our research group has showed that aqueous and hydroethanolic (HE) extracts from S. uncinata act as protectors against plasmid DNA cleavage by way of scavenging of superoxide radical anion and hydroxyl radical [10], and do not induce point mutations [13]. Nevertheless, these extracts induced an increase in DNA cleavage via a Fenton-like reaction [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the acute toxicity, phototoxicity and embryotoxicity of a residual aqueous fraction from extract of the Antarctic moss Sanionia uncinata

Fernandes¹,

Brito

Oliveira

et al. 2019

BMC Pharmacol Toxicol

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BackgroundUltraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection is important to control skin disorders. The Antarctic moss Sanionia uncinata is an important source of antioxidants and the photoprotective activity of its organic extracts has been investigated. This study aimed to evaluate the potential photoprotection, cytotoxicity and embryotoxicity of residual aqueous fraction (AF) from the moss S. uncinata.MethodsUV-visible spectrum and SPF (sun protection factor) were determined by spectrophotometry. Embryotoxicity potential was evaluated by Fish embryo-larval toxicity test using zebrafish (Danio rerio) as organism model. Cell death assays by water-soluble tetrazolium salt (WST-1) and lactate dehydrogenase (LDH) were investigated using HaCaT keratinocyte cell line cultured in monolayers and three dimensions (3D). Phototoxicity and association with UV-filters were performed by 3T3 neutral red uptake test.ResultsThe AF showed sharp absorption bands in the UV region and less pronounced in the visible region. The SPF was low (2.5 ± 0.3), but the SPF values of benzophenone-3 and octyl-methoxycinnamate increased ~ 3 and 4 times more, respectively, in association with AF. The AF did not induce significant lethal and sublethal effects on zebrafish early-life stages. In monolayers, the HaCaT cell viability, evaluated by WST-1, was above 70% by ≤0.4 mg AF/mL after 48 and 72-h exposure, whereas ≤1 mg AF/mL after 24-h exposure. The LDH assay showed that the cell viability was above 70% by ≤0.4 mg AF/mL even after 72-h exposure, but ≤1 mg/mL after 24 and 48-h exposure. In 3D cell culture, an increased cell resistance to toxicity was observed, because cell viability of HaCaT cell by WST-1 and LDH was above ~ 90% when using ≤1 and 4 mg AF/mL, respectively. The AF demonstrated values of photo irritation factor < 2 and of photo effect < 0.1, even though in association with UV-filters.ConclusionsThe residual AF absorbs UV-vis spectrum, increased SPF values of BP-3 and OMC and does not induce embryotoxicity to zebrafish early life-stage. The cell death assays allowed establishing non-toxic doses of AF and phototoxicity was not detected. AF of S. uncinata presents a good potential for skin photoprotection against UV-radiation.

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“…Moreover, plant extracts, through their synergistic effects with some physical or chemical UV filters (e.g., benzophenone-3 (BP-3), octyl methoxycinnamate (OMC) or titanium dioxide (TiO 2 )), may also play a role as cosmetic components that enhance the SPF of sunscreen formulations [40]. This effect has been shown for extracts from Sanionia uncinata [45,46], Vitis vinifera [47], Nephelium lappaceum [48], Psidium guajava [49], Campomanesia adamantium and Campomanesia xanthocarpa [50], as well as moss extracts from Leucobryum spp. and Holomitriopsis laevifolia [51].…”

Section: Plants As Photoprotective Agents Against Ultraviolet-radiati...mentioning

confidence: 99%

Plant Extracts as Skin Care and Therapeutic Agents

Michalak

2023

IJMS

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Natural ingredients have been used for centuries for skin treatment and care. Interest in the health effects of plants has recently increased due to their safety and applicability in the formulation of pharmaceuticals and cosmetics. Long-known plant materials as well as newly discovered ones are increasingly being used in natural products of plant origin. This review highlights the beneficial effects of plants and plant constituents on the skin, including moisturizing (e.g., Cannabis sativa, Hydrangea serrata, Pradosia mutisii and Carthamus tinctorius), anti-aging (e.g., Aegopodium podagraria, Euphorbia characias, Premna odorata and Warburgia salutaris), antimicrobial (e.g., Betula pendula and Epilobium angustifolium), antioxidant (e.g., Kadsura coccinea, Rosmarinus officinalis, Rubus idaeus and Spatholobus suberectus), anti-inflammatory (e.g., Antidesma thwaitesianum, Helianthus annuus, Oenanthe javanica, Penthorum chinense, Ranunculus bulumei and Zanthoxylum bungeanum), regenerative (e.g., Aloe vera, Angelica polymorpha, Digitaria ciliaris, Glycyrrihza glabra and Marantodes pumilum), wound healing (e.g., Agrimonia eupatoria, Astragalus floccosus, Bursera morelensis, Jatropha neopauciflora and Sapindus mukorossi), photoprotective (e.g., Astragalus gombiformis, Calea fruticose, Euphorbia characias and Posoqueria latifolia) and anti-tyrosinase activity (e.g., Aerva lanata, Bruguiera gymnorhiza, Dodonaea viscosa, Lonicera japonica and Schisandra chinensis), as well as their role as excipients in cosmetics (coloring (e.g., Beta vulgaris, Centaurea cyanus, Hibiscus sabdariffa and Rubia tinctiorum), protective and aromatic agents (e.g., Hyssopus officinalis, Melaleuca alternifolia, Pelargonium graveolens and Verbena officinalis)).

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Photoprotective and toxicological activities of extracts from the Antarctic moss Sanionia uncinata

Cited by 11 publications

References 17 publications

Hydroalcoholic Extract of Encholirium spectabile Mart. (Bromeliaceae) in O/W Emulsions as an Additive against the UVB Radiation

Hydroalcoholic Extract of Encholirium spectabile Mart. (Bromeliaceae) in O/W Emulsions as an Additive against the UVB Radiation

Evaluation of the acute toxicity, phototoxicity and embryotoxicity of a residual aqueous fraction from extract of the Antarctic moss Sanionia uncinata

Plant Extracts as Skin Care and Therapeutic Agents

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