Photopic Negative Response of Focal Electoretinograms in Glaucomatous Eyes

Abstract

The reduction of the focal PhNR amplitude was associated with a local decrease in the retinal sensitivity in OAG. The high sensitivity and specificity suggest that the focal PhNR can be used to detect functional loss in OAG.

Focal macular photopic negative response in patients with optic neuritis

“…12,15 PhNR is also selectively reduced in eyes with optic nerve atrophy, which is induced by trauma, compression, inflammation, ischemia, or gene mutation. [8][9][10] Our results provide additional evidence that focal macular PhNR is immediately and strongly attenuated by the onset of optic neuritis and that PhNR did not improve even after patients were treated with systemic corticosteroids, which resulted to improved visual acuity and visual field but not optic atrophy.…”

“…Recent studies have used focal macular ERG to record the PhNR from localized retinal areas. [12][13][14][15] Machida et al 12,15 suggested that focal PhNR can detect early glaucoma with higher sensitivity and specificity than full-field PhNR. Therefore, the reduction of focal macular PhNR amplitude in patients with optic neuritis suggests that an inner retinal dysfunction of the macula already exists at the onset of symptoms.…”

“…[8][9][10] Several researchers measured PhNR by using focal macular ERG in humans and monkeys. [11][12][13][14][15] Focal macular PhNR detected early glaucoma with higher sensitivity and specificity than full-field PhNR. 5,15 Most patients with acute idiopathic demyelinating optic neuritis have good visual acuity.…”

“…A number of studies have been done on recording PhNR from the macula in patients and monkeys with optic nerve disease, including glaucoma and optic nerve atrophy, 2,11,12,15 however, to our knowledge, the change in the focal macular PhNR during vision recovery from optic neuritis has not been investigated yet. This is important to gain a better understanding of the functional mechanisms during vision recovery, and the prediction of visual prognosis of optic neuritis.…”

Structures affecting recovery of macular function in patients with age-related macular degeneration after intravitreal ranibizumab

“…The PhNR amplitude was measured from the baseline to the negative trough at 70 msec according to the findings in earlier studies [18,19]. The amplitudes of OP1, OP2, and OP3 were measured and summed, and are designated as ΣOPs as reported [18,20].…”