2002
DOI: 10.1142/s1088424602000166
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Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes

Abstract: Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of c… Show more

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Cited by 28 publications
(35 citation statements)
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“…The increase in fluorescence continues with progressive increase in polymer concentration until saturation when Pc 4 is in its maximum equilibrium association state with the hydrophobic PCL core of the micelles. 6 From the spectrofluorometric data, the equilibrium association constant was determined using Eq. (1) which was reported by Rodriguez et al…”
Section: Pc 4 Encapsulation and Determination Of Association Constantmentioning
confidence: 99%
See 1 more Smart Citation
“…The increase in fluorescence continues with progressive increase in polymer concentration until saturation when Pc 4 is in its maximum equilibrium association state with the hydrophobic PCL core of the micelles. 6 From the spectrofluorometric data, the equilibrium association constant was determined using Eq. (1) which was reported by Rodriguez et al…”
Section: Pc 4 Encapsulation and Determination Of Association Constantmentioning
confidence: 99%
“…Active research in this area is evident from reports of (a) encapsulation of PS molecules in liposomes, [6][7][8][9] dendrimers, 10,11 micelles [12][13][14][15] and polymeric nanoparticles, 16-21 (b) conjugation of PS molecules to gold nanoparticles 22 and other inorganic nanoparticles, [23][24][25][26] and (c) engineering of a cell-selective delivery strategy of the nanoparticles or PS molecules themselves using tumor-homing motifs like albumin, transferrin, LDL, monoclonal antibodies and folic acid. 6,[27][28][29] Following this rationale, we are investigating the formulation of a PS, Pc 4, in biocompatible micelles from a polyethylene glycol-block-poly-e-caprolactone (PEG-PCL) block copolymer. Pc 4 ( Fig.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9] Such formulations, unfortunately, are developed mostly on an empirical basis, and systematic quantitative studies on the potential of a given formulation to solubilize a drug are lacking. The incorporation of 20-S-(+)-camptothecin (CPT) into liposomes is described in the literature mostly in a qualitative manner, 10 and the few quantitative data are difficult to compare because of the differences in their experimental approaches.…”
Section: Introductionmentioning
confidence: 99%
“…The fluorescence increases with additional liposomes until a maximum fluorescence intensity is reached, at which point Pc 4 is maximally monomerized. The blue-shift of the fluorescence spectra for Pc 4 is typical of the change in shape of spectra for other phthalocyanines upon addition of lipid [25]. The shape of the emission spectra is the same in PBS and in liposomal suspension, indicating that the monomer fluorescence specie is the same (Fig.…”
Section: Determination Of Binding Constants Of Pc 4 To Liposomesmentioning
confidence: 72%
“…Only Pc 4 monomers bind to liposomes and become fluorescent. Association constants for Pc 4 were calculated using equation 1 [25]:…”
Section: Binding Of Pc 4 and Nao To Liposomesmentioning
confidence: 99%