Photophysical properties and detection of Valrubicin on plasmonic platforms

Synak, Anna; Szczepańska, Elżbieta; Grobelna, Beata; Gondek, Joanna; Mońka, Michał; Gryczyński, Ignacy; Bojarski, Piotr

doi:10.1016/j.dyepig.2018.12.032

Cited by 12 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As illustrated in Scheme 2 a, the preparation of this nanocomposite was achieved in several steps. During the first step, the silver nanoparticles were prepared via the reduction of silver nitrate in an aqueous solution in the presence of trisodium citrate according to the procedure described previously [ 8 ]. Then, the obtained nanoparticles were coated with a silica nanolayer in the reaction of tetraethyl orthosilicate to obtain a spherical core-shell using the Stöber method [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…In the first stage of Ag@SiO 2 -NH 2 synthesis, the Ag@SiO 2 was obtained according to the method described by Synak et al [ 8 ]. Then, 0.7 mL of APTMS was added to 0.3 g of Ag@SiO 2 suspended in 3 mL of toluene in a bottom flask equipped with a reflux condenser.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, core-shell nanostructures have been selected as excellent candidates for applications in various branches of nanotechnology, including biosensing [ 6 ], targeted therapies [ 7 ], and metal enhanced fluorescence (MEF) [ 8 ]. The inorganic-organic nanocomposites of core-shell types that absorb in an ultraviolet/visible range and emit in a visible spectral domain can be particularly useful for bio-imaging [ 9 ], sensors design [ 10 ], safe sun-screens [ 11 ], and modern, very efficient, and selective drug carriers [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dansyl-Labelled Ag@SiO2 Core-Shell Nanostructures—Synthesis, Characterization, and Metal-Enhanced Fluorescence

et al. 2020

Self Cite

View full text Add to dashboard Cite

The present work describes synthesis, characterization, and use of a new dansyl-labelled Ag@SiO2 nanocomposite as an element of a new plasmonic platform to enhance the fluorescence intensity. Keeping in mind that typical surface plasmon resonance (SPR) characteristics of silver nanoparticles coincide well enough with the absorption of dansyl molecules, we used them to build the core of the nanocomposite. Moreover, we utilized 10 nm amino-functionalized silica shell as a separator between silver nanoparticles and the dansyl dye to prevent the dye-to-metal energy transfer. The dansyl group was incorporated into Ag@SiO2 core-shell nanostructures by the reaction of aminopropyltrimethoxysilane with dansyl chloride and we characterized the new dansyl-labelled Ag@SiO2 nanocomposite using transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR). Additionally, water wettability measurements (WWM) were carried out to assess the hydrophobicity and hydrophilicity of the studied surface. We found that the nanocomposite deposited on a semitransparent silver mirror strongly increased the fluorescence intensity of dansyl dye (about 87-fold) compared with the control sample on the glass, proving that the system is a perfect candidate for a sensitive plasmonic platform.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dansyl-Labelled Ag@SiO2 Core-Shell Nanostructures—Synthesis, Characterization, and Metal-Enhanced Fluorescence

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nowadays, various metal nanoparticles such as silver, gold or titanium are widely used not only in industry, but also in nanotechnology and other various fields of research [ 7 , 8 ]. The titanium dioxide nanoparticles (TiO 2 NPs) are utilized in many fields of industry [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Efficient Method for the Concentration Determination of Fmoc Groups Incorporated in the Core-Shell Materials by Fmoc–Glycine

et al. 2020

Self Cite

View full text Add to dashboard Cite

In this paper, we described the synthesis procedure of TiO2@SiO2 core-shell modified with 3-(aminopropyl)trimethoxysilane (APTMS). The chemical attachment of Fmoc–glycine (Fmoc–Gly–OH) at the surface of the core-shell structure was performed to determine the amount of active amino groups on the basis of the amount of Fmoc group calculation. We characterized nanostructures using various methods: transmission electron microscope (TEM), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) to confirm the modification effectiveness. The ultraviolet-visible spectroscopy (UV-vis) measurement was adopted for the quantitative determination of amino groups present on the TiO2@SiO2 core-shell surface by determination of Fmoc substitution. The nanomaterials were functionalized by Fmoc–Gly–OH and then the fluorenylmethyloxycarbonyl (Fmoc) group was cleaved using 20% (v/v) solution of piperidine in DMF. This reaction led to the formation of a dibenzofulvene–piperidine adduct enabling the estimation of free Fmoc groups by measurement the maximum absorption at 289 and 301 nm using UV-vis spectroscopy. The calculations of Fmoc loading on core-shell materials was performed using different molar absorption coefficient: 5800 and 6089 dm3 × mol−1 × cm−1 for λ = 289 nm and both 7800 and 8021 dm3 × mol−1 × cm−1 for λ = 301 nm. The obtained results indicate that amount of Fmoc groups present on TiO2@SiO2–(CH2)3–NH2 was calculated at 6 to 9 µmol/g. Furthermore, all measurements were compared with Fmoc–Gly–OH used as the model sample.

show abstract

“…The knowledge of whether we are dealing with aggregate or monomer form at a given concentration of the active compound is vital as the actual form may alter the pharmacological activity of the compound as well as its ability to penetrate through biological membranes. Molecular aggregates also play a crucial role as energy transmitters from sunlight in many biological systems [9][10][11][12] and their unusual optical properties are frequently studied and used in various fields of nanoscience and nanotechnology such as efficient energy collecting, spectral broadening of the optical response of fluorescent systems and biosensing on plasmonic platforms [13][14][15]. Although, TiO 2 nano-objects have demonstrated toxicity and ecotoxicity [16][17][18][19], its use in the biomedical devices is widespread and in many cases does not seem to lead to serious side effects.…”

Section: Introductionmentioning

confidence: 99%

The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application

et al. 2020

Self Cite

View full text Add to dashboard Cite

The investigation of innovative label-free α-amino acids detection methods represents a crucial step for the early diagnosis of several diseases. While 1,8-diazafluoren-9-one (DFO) is known in forensic application because of the fluorescent products by reacting with the amino acids present in the papillary exudate, its application for diagnostic purposes has not been fully investigated. The stabilization of DFO over a transparent substrate allows its complexation with biomolecules for the detection of α-amino acids. In this study, DFO was immobilized into a titanium dioxide (TiO2) matrix for the fluorescence detection of glycine, as a target α-amino acid (a potential marker of the urogenital tract cancers). The DFO/TiO2 composite was characterized by atomic force microscopy, spectroscopic ellipsometry, fluorescence spectroscopy and fluorescence microscopy. The performed fluorescent studies indicate spectacular formation of aggregates at higher concentration. The measurements performed using various fluorescence and microscopic techniques together with the suitable analysis show that the aggregates are able to emit short-lived fluorescence.

show abstract

Photophysical properties and detection of Valrubicin on plasmonic platforms

Cited by 12 publications

References 35 publications

Dansyl-Labelled Ag@SiO2 Core-Shell Nanostructures—Synthesis, Characterization, and Metal-Enhanced Fluorescence

Dansyl-Labelled Ag@SiO2 Core-Shell Nanostructures—Synthesis, Characterization, and Metal-Enhanced Fluorescence

Efficient Method for the Concentration Determination of Fmoc Groups Incorporated in the Core-Shell Materials by Fmoc–Glycine

The Luminescence of 1,8-Diazafluoren-9-One/Titanium Dioxide Composite Thin Films for Optical Application

Contact Info

Product

Resources

About