Photophysical characterization and in vitro anti-leishmanial effect of 5,10,15,20-tetrakis(4-fluorophenyl) porphyrin and the metal (Zn(II), Sn(IV), Mn(III) and V(IV)) derivatives

Espitia-Almeida, Fabián; Díaz‐Uribe, Carlos; Vallejo, William; Gómez‐Camargo, Doris; Bohórquez, Arnold R. Romero; Zárate, Ximena; Schott, Eduardo

doi:10.1007/s10534-021-00357-2

Cited by 5 publications

(1 citation statement)

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“…Thus, porphyrins can be tra formed into very useful chemical structures for designing and synthesizing novel co pounds with potential application in medicinal chemistry and the biological sciences [2 30]. The aforementioned structural modifications provide the porphyrin molecule wit certain degree of tropism or selectivity toward biological entities of interest, such as b teria, viruses, fungi, parasites, and tumor cells [7,[31][32][33][34]. For almost three decades, med inal chemistry studies on the development of novel drugs have been based on analyzi the chemical structure and biological activity of a molecule (QSARs-quantitative stru ture-activity relationships) to predict and optimize pharmacological activity [35,36].…”

Section: Porphyrin Structural Characterization Via Uv-vismentioning

confidence: 99%

Photodynamic Antimicrobial Activity of a Novel 5,10,15,20-Tetrakis (4-Ethylphenyl) Porphyrin against Clinically Important Bacteria

et al. 2023

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The growing emergence of microbes resistant to commercially available antibiotic therapies poses a threat to healthcare systems worldwide. Multiple factors have been associated with the increasing incidence of hospital-acquired infections caused by antibiotic-resistant pathogens, including the indiscriminate use of broad-spectrum antibiotics, the massive application of antibiotics in hospitals as a prophylactic measure, self-medication, and nonadherence to pharmacological therapies by patients. In this study, we developed a novel treatment to mitigate the impact of microbial resistance. We synthesized a benzoporphyrin derivative, 5,10,15,20-tetrakis (4-ethylphenyl) porphyrin (TEtPP), with a reaction yield close to 50%. TEtPP exhibited excellent photophysical properties (Φf = 0.12 ± 0.04 and ΦΔ = 0.81 ± 0.23) and was thereby assessed as a potential agent for antibacterial photodynamic therapy. The photophysical properties of the synthesized porphyrin derivative were correlated with the assayed antimicrobial activity. TEtPP showed higher activity against the MRSA strain under irradiation than in the absence of irradiation (minimum inhibitory concentration (MIC) = 69.42 µg/mL vs. MIC = 109.30 µg/mL, p < 0.0001). Similar behavior was observed against P. aeruginosa (irradiated MIC = 54.71 µg/mL vs. nonirradiated MIC = 402.90 µg/mL, p < 0.0001). TEtPP exhibited high activity against S. aureus in both the irradiated and nonirradiated assays (MIC = 67.68 µg/mL vs. MIC = 58.26 µg/mL, p = 0.87).

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