Photophysical and antimicrobial properties of new double-armed benzo-15-crown-5 ligands and complexes

rac‐ and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies

“…Systemic fungal infections, including those by C. albicans , have emerged as important causes of morbidity and mortality in immune‐compromised patients (AIDS, cancer chemotherapy, organ or bond transplantation) . All the synthesized compounds (except for meso ‐compound 19 ) demonstrated high activity against this yeast.…”

“…Some compounds and antibiotics exhibited varying degrees of inhibitory effects on the growth of the different Gram‐negative and ‐positive pathogenic bacteria and yeast tested. The synthesized rac ‐ and meso ‐compounds ( 7, 8, 10, 17, 18 , and 19 ) were screened for their in vitro antibacterial and antifungal activity in dimethyl sulfoxide (DMSO) at the same concentrations (0.1 µg/µl) as a test material (Tables and ) . The results are plotted in Figures and at the same concentration and in the same solvent.…”

“…These pathogenic microorganisms are continuing to gain resistance to traditional antibiotics. There is a need for more effective antibiotics for the treatment of this disease . The rac ‐compound 10 showed the most activity against S. aureus (25 mm), P. putida (23 mm), and S. typhi H (22 mm) (Table and Figure ).…”

“…The pathogenic bacterial cultures chosen were S. aureus ATCC25923, E. coli ATCC1280, S. typhi H NCTC901.8394, S. epidermis ATCC12228, M. luteus ATCC9341, B. cereus RSKK‐863, E. aerogenes sp., K. pneumonia ATCC 27853, P. vulgaris RSKK 96026, P. putida sp., and yeast used were C. albicans Y‐1200‐NIH.…”

“…All intermediate and final products obtained were separated and purified by using traditional chromatographic techniques, and all the purified products were clarified by spectroscopic methods and were screened against α‐ and β‐glucosidases using acarbose as a positive control. Newly synthesized compounds ( rac ‐ 10 , ‐ 17 , and meso ‐ 7 , ‐ 8 , ‐ 18 , ‐ 19 ) were investigated for their antimicrobial activity against pathogenic strains (Gram[−] and Gram[+] bacteria and yeast): Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas putida, Escherichia coli, Salmonella typhi H, Micrococcus luteus, Bacillus cereus , Klebsiella pneumoniae, Proteus vulgaris, Enterobacter aerogenes , and Candida albicans . Molecular modeling studies were performed for the same molecules 7, 8, 10, 17, 18 , and 19 , as well as maltose, obtained from the crystal structure active site, and they were docked into the active site of Saccharomyces cerevisiae α‐glucosidase.…”