Photopheresis for the treatment of cutaneous T cell lymphoma

Armus, Steven; B, Keyes; Cahill, Carol; Berger, Carole L.; D, Crater; Scarborough, Dwight A.; Klainer, Albert S.; Bisaccia, Emil

doi:10.1016/0190-9622(90)70312-6

Cited by 87 publications

(31 citation statements)

References 5 publications

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“…5 In addition, experimental data acquired from animal autoimmune and transplantation studies suggest that photopheresed cells induce an antigenspecific immune response directed to pathogenic T-cell populations without affecting general immunocompetence. [15][16][17] In the case of scleroderma, there is quite strong evidence now of ongoing abnormal immune activation detectable by the presence of activated T cells both within the peripheral blood and at sites of abnormal collagen production. 18 These cells may be indirectly involved in enhancing collagen synthesis and deposition via the secretion of cytokines such as transforming growth factor-b.…”

Section: Discussionmentioning

confidence: 97%

A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis

Knobler

French

Kim

et al. 2006

Journal of the American Academy of Dermatology

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113

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Section: Discussionmentioning

confidence: 97%

A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis

Knobler

French

Kim

et al. 2006

Journal of the American Academy of Dermatology

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113

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“…50 As part of extra corporeal photopheresis UV-B modulates immunoresponse and is able to meliorate the clinical course of cutanous T-cell lymphoma. 51,52 UV-B induces mainly dipyrimidine photoproducts in DNA by a direct photochemical mechanism, whereas UV-A, which reaches deeper skin strata, is absorbed by other cellular constituents and induces mainly oxidative damage indirectly. For UV-A, immune suppressive as well as immune stimulating effects are discussed.…”

Section: Biological Plausibilitymentioning

confidence: 99%

Sun exposure and malignant lymphoma: A population‐based case–control study in Germany

Weihkopf

Becker

Nieters

et al. 2007

Intl Journal of Cancer

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Although some causes for malignant lymphoma are known their etiology is not well understood so far. We analyze the relationship between sun exposure and malignant lymphoma in a multicenter, population-based case-control study. Patients with malignant lymphoma (n 5 710, 18-80 years) were prospectively recruited in 6 study regions in Germany. For each case, a gender, region and age-matched control was drawn from population-registers. In personal interviews, lifetime holidays spent in sunny climate, outdoor leisure activities and sunbed or sunlamp use were recorded. On basis of job task-specific supplementary questionnaires, an occupational physician assessed the cumulative working time outside. Odds ratios (OR) and 95%-confidence-intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking and alcohol consumption. To increase statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression. We observed a reduced overall lymphoma risk among subjects having spent vacations at sunny climates or frequently used sunbeds or sunlamps. The analysis of lymphoma subentities revealed similar results with the exception of T-NHL and follicular lymphoma which were positively associated with outdoor leisure activities. While cumulative working time outside appeared unrelated to NHL overall and most subentities, it was negatively associated with follicular lymphoma and weakly positively to HL. This data suggest that exposure to natural and artificial ultraviolet radiation may reduce the OR for lymphoma in this study population. ' 2007 Wiley-Liss, Inc.

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“…Forty-nine patients were identified as having a diagnosis of SS as defined by (1) erythroderma, (2) Sé-zary cells (atypical lymphocytes Ͼ10% of peripheral blood mononuclear cells), (3) clonal TCR ␤ gene rearrangement detected in peripheral blood lymphocytes using Southern blot analysis, 13 and (4) skin histological findings consistent with a diagnosis of CTCL. Of these, 2 patients were unavailable for follow-up and the medical records were missing for 3 patients.…”

Section: Methodsmentioning

confidence: 99%

“…11 Several smaller studies of the use of ECP in CTCL have since been published, commenting on clinical response. [12][13][14] Two recent articles reported median survivals of 96 months (20 patients) 15 and greater than 100 months from diagnosis (28 patients). 16 There have, however, been no controlled trials comparing ECP with conventional therapies.…”

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confidence: 99%