Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice

Otsuka, Tsuyoshi; Kawai, Misako; Togo, Yuki; Goda, Ryosei; Kawase, Takahiro; Matsuo, Haruka; Iwamoto, Ayaka; Nagasawa, Mao; Furuse, Mitsuhiro; Yasuo, Shinobu

doi:10.1016/j.psyneuen.2013.10.013

Cited by 54 publications

(30 citation statements)

References 30 publications

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“…Four weeks of a 12 h/12 h light/dark cycle under dim illumination conditions (50 lux/1 lux) attenuated indices of serotonin signaling in the dorsal raphe nucleus in grass rats (A. niloticus) [34]. Three weeks of a short photoperiod (8 h/16 h light/dark cycle) induced lower brain levels of serotonin and its precursor l-tryptophan in C57BL/6J mice [35]. Combined with the present results, these previous studies (although they used different strains of rodents and different light/cycle schedules from the present study) indicate that elevated plasma levels of CORT and blunted diurnal rhythmicity may explain why light/dark cycles can impact the resiliency to stress during adolescence.…”

Section: Rhythms Of Plasma Levels Of Corticosterone Melatonin and Nmentioning

confidence: 98%

Short photoperiod condition increases susceptibility to stress in adolescent male rats

Liu

Yuan

et al. 2016

Behavioural Brain Research

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Section: Rhythms Of Plasma Levels Of Corticosterone Melatonin and Nmentioning

confidence: 98%

Short photoperiod condition increases susceptibility to stress in adolescent male rats

Liu

Yuan

et al. 2016

Behavioural Brain Research

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“…A recent study revealed more frequent depression-like behavior in mice kept in SD conditions compared with those kept in LD conditions (Otsuka et al 2014). The level of serotonin in the brain is also decreased in LD conditions (Otsuka et al 2014).…”

Section: Seasonal Rhythms In Humansmentioning

confidence: 96%

Molecular basis for regulating seasonal reproduction in vertebrates

Nishiwaki‐Ohkawa

Yoshimura

2016

Journal of Endocrinology

101

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Animals that inhabit mid- to high-latitude regions exhibit various adaptive behaviors, such as migration, reproduction, molting and hibernation in response to seasonal cues. These adaptive behaviors are tightly regulated by seasonal changes in photoperiod, the relative day length vs night length. Recently, the regulatory pathway of seasonal reproduction has been elucidated using quail. In birds, deep brain photoreceptors receive and transmit light information to the pars tuberalis in the pituitary gland, which induces the secretion of thyroid-stimulating hormone. Thyroid-stimulating hormone locally activates thyroid hormone via induction of type 2 deiodinase in the mediobasal hypothalamus. Thyroid hormone then induces morphological changes in the terminals of neurons that express gonadotropin-releasing hormone and facilitates gonadotropin secretion from the pituitary gland. In mammals, light information is received by photoreceptors in the retina and neurally transmitted to the pineal gland, where it inhibits the synthesis and secretion of melatonin, which is crucial for seasonal reproduction. Importantly, the signaling pathway downstream of light detection and signaling is fully conserved between mammals and birds. In fish, the regulatory components of seasonal reproduction are integrated, from light detection to neuroendocrine output, in a fish-specific organ called the saccus vasculosus. Various physiological processes in humans are also influenced by seasonal environmental changes. The findings discussed herein may provide clues to addressing human diseases, such as seasonal affective disorder.

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“…Laboratory mice have been proposed as an animal model of SAD (Otsuka et al, 2014). However, the reported data about effect of photoperiod alteration on mouse behavior are contradictory (Otsuka et al, 2014;Young et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of lethal yellow (AY) mutation and photoperiod alterations on mouse behavior

et al. 2019

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Decrease in natural illumination in fall/winter months causes depressive-like seasonal affective disorders in vulnerable individuals. Obesity is another risk factor of depression. The lethal yellow (A Y ) mutation causes ectopic expression of agouti protein in the brain. Mice heterozygous for A Y mutation (A Y /a) are obese compared to their wild-type littermates (a/a). The main aims of the study were to investigate the effects of A Y mutation, photoperiod and the interaction between these factors on daily activity dynamics, feeding, locomotor and exploratory activities, anxiety-related and depressive-like behaviors in mild stress condition. Six weeks old mouse males of A Y /a and a/a lines were divided into four groups eight animals each and exposed to long-(14 h light and 10 h darkness) or short-(4 h light and 20 h darkness) day conditions for 28 days. Then the behavior of these mice was successively investigated in the home cage, open field, elevated plus-maze and forced swim tests. We did not observed any effect of A Y mutation on the general activity, water and food consumption in the home cage; locomotion and exploration in the open field test; anxiety-related behavior in the open field and elevated plus-maze tests. At the same time, A Y mutation increased depressive-like immobility time in the forced swim test (F 1.28 = 20.03, p = 0.00012). Shortday conditions decreased nocturnal activity in the home cage, as well as locomotion (F 1.28 = 16.33, p = 0.0004) and exploration (F 1.28 = 16.24, p < 0.0004) in the open field test. Moreover, short-day exposition decreased time spent in the center of the open field (F 1.28 = 6.57, p = 0.016) and in the open arms of the elevated plus-maze (F 1.28 = 12.08, p = 0.0017) tests and increased immobility time in the forced swim test (F 1.28 = 9.95, p = 0.0038). However, no effect of the interaction between A Y mutation and photoperiod on immobility time in the forced swim test was observed. Therefore, short-day photoperiod and A Y mutation increased depressive-like behavior in the forced swim test by means of different mechanisms.For citation: Bazhenova E.Y., Fursenko D.V., Khotskin N.V., Sorokin I.E., Kulikov A.V. Effect of lethal yellow (A Y ) mutation and photoperiod alterations on mouse behavior.

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Photoperiodic responses of depression-like behavior, the brain serotonergic system, and peripheral metabolism in laboratory mice

Cited by 54 publications

References 30 publications

Short photoperiod condition increases susceptibility to stress in adolescent male rats

Short photoperiod condition increases susceptibility to stress in adolescent male rats

Molecular basis for regulating seasonal reproduction in vertebrates

Effect of lethal yellow (AY) mutation and photoperiod alterations on mouse behavior

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