Photopatch Testing

Gonçalo, Margarida

doi:10.1007/978-3-030-36335-2_29

Cited by 6 publications

(9 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The irradiated area is examined before and immediately after irradiation (that is, 24 hours after application of the test substances), as well as after 48 and 72 hours. After 24 and 48 hours, respectively, the test block of the non-irradiated tests is also removed and the test reactions in the non-irradiated area are examined for the same time intervals [49][50][51]. The observation of the reaction over a period of 72 hours facilitates the differentiation between phototoxic and photoallergic reaction: the latter is characterized by a delayed onset with a crescendo pattern -apart from erythema and infiltrate, papulovesicles, blisters, or erosions are common.…”

Section: Additional In Vivo Test Methodsmentioning

confidence: 99%

“…Causal factors are contact to contact allergens (haptens) in allergic contact dermatitis, contact to photoallergens in combination with exposure to ultraviolet (UV) radiation in photoallergic contact dermatitis, contact to chromophore-containing substances together with UV radiation in phototoxic contact dermatitis, and contact to proteins in protein contact dermatitis. Tables 1 and 3 provide an overview of the different forms of contact dermatitis, their triggers, and the indicative diagnostic workup [11,[49][50][51][52][53][54][55]. The frequent occurrence of multifactorial contact eczemas (especially on the hands) has been emphasized repeatedly [2,56].…”

Section: History In Case Of Suspected Contact Dermatitismentioning

confidence: 99%

See 1 more Smart Citation

German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Contact dermatitis is an inflammation of the epidermis and dermis at the site of exposure triggered by external agents. The two main forms are irritant and allergic contact dermatitis, which cause significant health and socioeconomic costs in addition to a marked reduction in quality of life. The anamnesis and the clinical picture are decisive for the necessary diagnostic measures. The most accurate possible diagnostic classification of contact dermatitis by means of allergological testing is important for disease management, since not only classical eczema therapy but also avoidance of the exogenous triggering factors are of great importance here. The choice of therapy should be based on the acuity, clinical severity, morphology of the lesions and localization of the contact dermatitis. A combination of basic therapy, topical, physical, and systemic therapy adapted to the patient’s needs is required, whereby not all forms of therapy must be carried out simultaneously but can be used in a varying manner. Primary, secondary, and tertiary prevention strategies aim at the recognition of the triggering noxae or allergens with subsequent contact avoidance or minimization. The present S1‐guideline on contact dermatitis is primarily intended to provide dermatologists, allergologists and physicians working in allergology and occupational dermatology with a decision‐making aid for the selection and implementation of suitable and sufficient diagnostics, therapy, and prevention.

show abstract

Section: Additional In Vivo Test Methodsmentioning

confidence: 99%

Section: History In Case Of Suspected Contact Dermatitismentioning

confidence: 99%

German S1 guideline: Contact dermatitis

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“…Beim allergischen Kontaktekzem sind der Kontakt zu Kontaktallergenen (Haptenen), beim photoallergischen Kontaktekzem zu Photoallergenen in Verbindung mit der Einwirkung von ultravioletter (UV-)Strahlung, beim phototoxischen Kontaktekzem Kontakt zu Chromophoren-haltigen Substanzen zusammen mit UV-Strahlung, bei der Proteinkontaktdermatitis zu Proteinen ursächlich. Die Tabellen 1 und 3 geben einen Überblick über unterschiedliche Kontaktekzeme, ihre Auslöser und richtungsweisende Diagnostik [11,[49][50][51][52][53][54][55]. Auf das häufige Vorkommen multifaktorieller Kontaktekzeme (vor allem an den Händen) wurde wiederholt hingewiesen [2,56].…”

Section: Diagnostik Und Differenzialdiagnostikunclassified

S1‐Leitlinie Kontaktekzem

Bauer

Mahler

Neustädter

et al. 2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Zusammenfassung Das Kontaktekzem (syn. Kontaktdermatitis) ist eine durch äußere Einwirkungen ausgelöste Entzündung der Epidermis und der Dermis am Ort der Einwirkung. Die beiden Hauptformen sind das irritative und das allergische Kontaktekzem, die neben einer ausgeprägten Verminderung der Lebensqualität auch erhebliche gesundheits‐ und sozioökonomische Kosten verursachen. Wegweisend für die erforderlichen diagnostischen Maßnahmen sind die Anamnese und das klinische Bild. Eine möglichst genaue diagnostische Einordnung des Kontaktekzems mittels allergologischer Testung ist wichtig für das Krankheitsmanagement, da hier nicht nur die klassische Ekzemtherapie, sondern auch das Meiden der exogenen auslösenden Faktoren von großer Bedeutung sind. Die Wahl der Therapie sollte sich nach der Akuität, dem klinischen Schweregrad, der Morphologie der Läsionen und der Lokalisation des Kontaktekzems richten. Erforderlich ist eine bedarfsadaptierte Kombination aus Basistherapie, topischer, physikalischer und systemischer Therapie, wobei nicht alle Therapieformen gleichzeitig durchgeführt werden müssen, sondern variierend eingesetzt werden können. Primäre, sekundäre und tertiäre Präventionsstrategien zielen auf die Erkennung der auslösenden Noxen beziehungsweise der auslösenden Allergene mit nachfolgender Kontaktvermeidung oder ‐minimierung. Die vorliegende S1‐Leitlinie zum Kontaktekzem soll vor allem Dermatologen, Allergologen sowie allergologisch und berufsdermatologisch tätigen Ärzten eine Entscheidungshilfe für die Auswahl sowie die Durchführung einer geeigneten und suffizienten Diagnostik, Therapie und Prävention zur Verfügung zu stellen.

show abstract

“…When photoallergic contact dermatitis is suspected on the basis of patient history and clinical manifestations (allergic contact dermatitis at sites exposed to sunlight or artificial UV radiation), photopatch tests should be performed. 135,136 Because photoallergic contact dermatitis is relatively infrequent, the practice of photopatch testing is fairly complicated, time-consuming, and laborious, and the yield of positive reactions is usually less than 20%, 137 few dermatologists in general hospitals or private practice and not all university centers perform this diagnostic procedure. In photopatch testing, 2 sets of allergens are applied for 1 or 2 days, after which 1 set is irradiated with 5 J/cm 2 of UV-A.…”

Section: Photopatch Testingmentioning

confidence: 99%

“…Readings are performed immediately after irradiation and 2 or more days thereafter. 136 Patients may be routinely tested with the European photopatch test baseline series (n = 20) and-either routinely or on indication-with the extended series of photoallergens (n = 15), consisting mostly of UV filters and (topical) drugs, particularly NSAIDs (Table 12). 135 Apart from the baseline and the extended baseline series, patients' own products or other chemicals to which he or she was exposed to should also be considered for photopatch testing.…”

Section: Photopatch Testingmentioning

confidence: 99%