Photonic integrated circuits for Department of Defense-relevant chemical and biological sensing applications: state-of-the-art and future outlooks

Chandrasekar, Rohith; Lapin, Zachary J.; Nichols, Andrew S.; Braun, R.; Fountain, Augustus W.

doi:10.1117/1.oe.58.2.020901

Cited by 52 publications

(24 citation statements)

References 61 publications

(68 reference statements)

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“…The designed nanophotonic structures significantly reduce the footprint, reduce the insertion loss, and improve the mechanical robustness of on-chip light coupling into the PhC structure, which are desired for improving sensitivity in nanophotonic sensors [34][35][36] and reducing operation power for PhC-based active silicon photonic components.…”

Section: Resultsmentioning

confidence: 99%

Engineering the light coupling between metalens and photonic crystal resonators for robust on-chip microsystems

Xiao

Wang

et al. 2021

J. Optical Microsystems

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We designed an on-chip transformative optic system with a broadband metalens coupler on a foundry compatible silicon photonic platform. By adjusting the on-chip metalens' focusing length and mode dimension, the insertion loss between the metalens and the photonic crystal waveguide (PhC WG) structures is reduced to 2 dB by matching the mode on the metalens focal plane to the PhC WG mode. Alternatively, the integrated metalens allow for direct coupling from a multi-mode WG to the PhC cavity. The on-resonance transmission in a lenscavity-lens microsystem achieves 60%. These micro-systems do not involve any single-mode silicon nanowire WG, and even a suspended PhC structure can be mechanically robust against vibrations. The proposed microsystem can be a new platform for miniaturized chemical and biosensor applications operating in air or solution environments. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Resultsmentioning

confidence: 99%

Engineering the light coupling between metalens and photonic crystal resonators for robust on-chip microsystems

Xiao

Wang

et al. 2021

J. Optical Microsystems

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“…Microfluidic channels have been successfully attached to the novel sensors, allowing their exploitation and integration in different setups, such as into the SWINOSTICS device. PICs have been proposed as capable tools for the detection of various analytes such as gases, small molecules and biomolecules [ 18 , 19 , 20 ]. However, PICs have not yet been proposed as a sensing platform in veterinary diagnostics.…”

Section: Discussionmentioning

confidence: 99%

Photonic Label-Free Biosensors for Fast and Multiplex Detection of Swine Viral Diseases

Navarro-Arenas

Sánchez²,

Peransi-Llopis³

et al. 2022

Sensors

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In this paper we present the development of photonic integrated circuit (PIC) biosensors for the label-free detection of six emerging and endemic swine viruses, namely: African Swine Fever Virus (ASFV), Classical Swine Fever Virus (CSFV), Porcine Reproductive and Respiratory Syndrome Virus (PPRSV), Porcine Parvovirus (PPV), Porcine Circovirus 2 (PCV2), and Swine Influenza Virus A (SIV). The optical biosensors are based on evanescent wave technology and, in particular, on Resonant Rings (RRs) fabricated in silicon nitride. The novel biosensors were packaged in an integrated sensing cartridge that included a microfluidic channel for buffer/sample delivery and an optical fiber array for the optical operation of the PICs. Antibodies were used as molecular recognition elements (MREs) and were selected based on western blotting and ELISA experiments to ensure the high sensitivity and specificity of the novel sensors. MREs were immobilized on RR surfaces to capture viral antigens. Antibody–antigen interactions were transduced via the RRs to a measurable resonant shift. Cell culture supernatants for all of the targeted viruses were used to validate the biosensors. Resonant shift responses were dose-dependent. The results were obtained within the framework of the SWINOSTICS project, contributing to cover the need of the novel diagnostic tools to tackle swine viral diseases.

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“…It may also be possible to enhance the detection sensitivity by coating the top and sides of the waveguide with a sorbent that selectively interacts with and concentrates a given class of chemicals, which diffuse into the sorbent layer. This can increase the molecular concentration, and hence the detection sensitivity to a given chemical by orders of magnitude [ 61 , 62 , 63 ].…”

Section: Practical Considerationsmentioning

confidence: 99%

Interband Cascade Photonic Integrated Circuits on Native III-V Chip

Meyer

Kim

et al. 2021

Sensors

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We describe how a midwave infrared photonic integrated circuit (PIC) that combines lasers, detectors, passive waveguides, and other optical elements may be constructed on the native GaSb substrate of an interband cascade laser (ICL) structure. The active and passive building blocks may be used, for example, to fabricate an on-chip chemical detection system with a passive sensing waveguide that evanescently couples to an ambient sample gas. A variety of highly compact architectures are described, some of which incorporate both the sensing waveguide and detector into a laser cavity defined by two high-reflectivity cleaved facets. We also describe an edge-emitting laser configuration that optimizes stability by minimizing parasitic feedback from external optical elements, and which can potentially operate with lower drive power than any mid-IR laser now available. While ICL-based PICs processed on GaSb serve to illustrate the various configurations, many of the proposed concepts apply equally to quantum-cascade-laser (QCL)-based PICs processed on InP, and PICs that integrate III-V lasers and detectors on silicon. With mature processing, it should become possible to mass-produce hundreds of individual PICs on the same chip which, when singulated, will realize chemical sensing by an extremely compact and inexpensive package.

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Photonic integrated circuits for Department of Defense-relevant chemical and biological sensing applications: state-of-the-art and future outlooks

Cited by 52 publications

References 61 publications

Engineering the light coupling between metalens and photonic crystal resonators for robust on-chip microsystems

Engineering the light coupling between metalens and photonic crystal resonators for robust on-chip microsystems

Photonic Label-Free Biosensors for Fast and Multiplex Detection of Swine Viral Diseases

Interband Cascade Photonic Integrated Circuits on Native III-V Chip

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