Photonic enhancement in photoluminescent metal halide perovskite–photonic crystal bead hybrids

Lapointe, Victoria; Imperiale, Christian J.; Chengadu, Sollavi; Pomilio, Cristina; Ganesh, Meera; Kéna‐Cohen, Stéphane; Majewski, Marek B.

doi:10.1039/d3cc02962j

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…These results, along with those in Table , point to the ongoing renaissance in photochemistry − transferring into pharmaceutical process chemistry departments. In the next few decades, photochemistry will be a standard technology within a process chemist or engineers’ toolbox, as a more fundamental understanding of UV and photoredox chemistry is gained, allowing process chemists to better understand the chemistry and process engineers to design equipment to overcome any scale-up challenges.…”

Section: Resultsmentioning

confidence: 53%

Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

Moschetta,

Cook,

Edwards

et al. 2024

Org. Process Res. Dev.

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We present and analyze the results of a pharmaceutical industry-wide survey of the strategies and approaches that companies have for implementing photochemical reactions in discovery chemistry, process development, and commercial manufacturing. The survey questions encompass the types of photochemical reactions that pharmaceutical companies pursue and why, the types of reactors (batch and flow) used, how they are characterized for photochemistry, scale-up of photochemical reactions, and how companies prioritize resources for developing photochemical reactions, among other topics. The survey focuses on many of these topics from the perspectives of discovery chemists and process scientists to highlight similarities and differences between their approaches on the specific photochemical transformations and materials of construction used in photochemical reactors. The survey results clearly demonstrate that photochemistry is a viable synthetic strategy for producing active pharmaceutical ingredients (APIs), from discovery all the way to commercialization. While photochemistry is more prevalent for discovery and early stage process development, the survey results indicate that more companies are leveraging photochemistry in successful scale-ups in later stages of process development, often using flow chemistry, and have significant knowledge resulting from these experiences. Nevertheless, there still are gaps to adopting photochemical reactions across stages of development and companies have very limited experience discussing photochemistry with regulatory agencies. Overall, the survey results demonstrate that photochemistry offers considerable benefits for synthesizing APIs and developing API processes, such as greenness and sustainability, shortening synthetic routes, and potential for improved product quality.

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Section: Resultsmentioning

confidence: 53%

Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

Moschetta,

Cook,

Edwards

et al. 2024

Org. Process Res. Dev.

View full text Add to dashboard Cite

show abstract

Photonic enhancement in photoluminescent metal halide perovskite–photonic crystal bead hybrids

Abstract: The integration of photonic materials with semiconductor nanocrystals by correlating the photonic stopband and the photoluminescence maximum is expected to afford hybrid materials with enhanced optoelectronic properties. Here, we report...

Cited by 1 publication

References 33 publications

Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation

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