Photonic crystal microarray nanoplatform for high throughput detection of biomolecules

Abstract

We present preliminary designs and experimental results for creating a microarray nanoplatform based on twodimensional photonic crystal devices in silicon. Multiple photonic crystal microcavities are coupled along the length of a single photonic crystal waveguide that undergo resonance wavelength shifts when an antibody-antibody binding event occurs in the immediate vicinity of the corresponding photonic crystal microcavity. The microarray nanoplatform enables high throughput measurements of multiple antibody-antibody interactions via a single optical waveguide transmission measurement.

Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds

“…Bioinspired nanostructured materials exhibiting photonic properties and structural colors have been fabricated for various purposes by controlling composition, additives, and arrangement, among others [ 150 ]. Proving its usefulness in HTS, the ability of PCs to identify modulators of protein–protein interactions [ 151 ], to discover inhibitors of protein–DNA interactions [ 152 ] ( Figure 6 ), and to measure antibody–antibody binding [ 153 ] has been demonstrated. Another interesting example of the use of PCs for HTS screening is in cell-based assays.…”