Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions

Jensen, Jørgen Birger; Pedersen, Lars H.; Høiby, Poul E.; Nielsen, Lars; Hansen, Thorkild B.; Folkenberg, Jacob Riis; Riishede, Jesper; Noordegraaf, Danny; Nielsen, Kristian; Carlsen, Anneline; Bjarklev, Anders

doi:10.1364/ol.29.001974

Cited by 314 publications

(159 citation statements)

References 6 publications

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“…7,14 LPFGs can thus be used for biochemical sensing based on the evanescent-wave detection principle. [151][152][153][154][155] As shown in Fig. 21, a promising biochemical sensor based on a LPFG written in a PCF by a CO 2 laser has been demonstrated to detect the average thickness of a layer of biomolecules within a few nm.…”

Section: F Biochemical Sensorsmentioning

confidence: 99%

Review of long period fiber gratings written by CO2 laser

Wang

2010

Journal of Applied Physics

220

134

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This paper presents a systematic review of long period fiber gratings (LPFGs) written by the CO2 laser irradiation technique. First, various fabrication techniques based on CO2 laser irradiations are demonstrated to write LPFGs in different types of optical fibers such as conventional glass fibers, solid-core photonic crystal fibers, and air-core photonic bandgap fibers. Second, possible mechanisms, e.g., residual stress relaxation, glass structure changes, and physical deformation, of refractive index modulations in the CO2-laser-induced LPFGs are analyzed. Third, asymmetrical mode coupling, resulting from single-side laser irradiation, is discussed to understand unique optical properties of the CO2-laser-induced LPFGs. Fourthly, several pretreament and post-treatment techniques are proposed to enhance the efficiency of grating fabrications. Fifthly, sensing applications of the CO2-laser-induced LPFGs are investigated to develop various LPFG-based temperature, strain, bend, torsion, pressure, and biochemical sensors. Finally, communication applications of the CO2-laser-induced LPFGs are investigated to develop various LPFG-based band-rejection filters, gain equalizers, polarizers, and couplers.

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Section: F Biochemical Sensorsmentioning

confidence: 99%

Review of long period fiber gratings written by CO2 laser

Wang

2010

Journal of Applied Physics

220

134

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“…It has been shown that photonic crystal fibers can be used for evanescent-wave sensing of biomolecules, such as DNA [14] or proteins [15]. These experiments were done using labelled biomolecules, where each target molecule carries a fluorescent tag.…”

Section: Introductionmentioning

confidence: 99%

Photonic crystal fiber long-period gratings for biochemical sensing

Rindorf¹,

Jensen²,

Dufva³

et al. 2006

Opt. Express

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Abstract:We present experimental results showing that long-period gratings in photonic crystal fibers can be used as sensitive biochemical sensors. A layer of biomolecules was immobilized on the sides of the holes of the photonic crystal fiber and by observing the shift in the resonant wavelength of a long-period grating it was possible to measure the thickness of the layer. The long-period gratings were inscribed in a large-mode area silica photonic crystal fiber with a CO 2 laser. The thicknesses of a monolayer of poly-L-lysine and double-stranded DNA was measured using the device. We find that the grating has a sensitivity of approximately 1.4nm/1nm in terms of the shift in resonance wavelength in nm per nm thickness of biomolecule layer.

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“…Fiber-based fluorescence sensing has been deployed in sensing targets such as: aluminum ions [7], hydrogen peroxide [8], oxygen [9], and explosives [10]. Optical fiber based fluorescence sensors have also been deployed for biological applications, including measurements of biomolecules in solution [11], DNA [12], or enzyme assays within microstructured fibers [13].…”

Section: Introductionmentioning

confidence: 99%

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

et al. 2016

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Rights url: https://www.osapublishing.org/submit/review/copyright_permissions.cfm# Creative Commons LicensingOSA is aware that some authors, as a condition of their funding, must publish their work under a Creative Commons license. We therefore offer a CC BY license for authors who indicate that their work is funded by agencies that we have confirmed have this requirement. Authors must enter their funder(s) during the manuscript submission process. At that point, if appropriate, the CC BY license option will be available to select for an additional fee.Any subsequent reuse or distribution of content licensed under CC BY must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Abstract: Microstructured optical fibers, particularly those with a suspended-core geometry, have frequently been argued as efficient evanescent-field fluorescence-based sensors. However, to date there has not been a systematic comparison between such fibers and the more common geometry of a multi-mode fiber tip sensor. In this paper we make a direct comparison between these two fiber sensor geometries both theoretically and experimentally.Our results confirm that suspended-core fibers provide a significant advantage in terms of total collected fluorescence signal compared to multi-mode fibers using an equivalent experimental configuration. Noordegraaf, K. Nielsen, A. Carlsen, and A. Bjarklev, "Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions," Opt. Lett. 29(17), 1974-1976 (2004). 12. E. Coscelli, M. Sozzi, F. Poli, D. Passaro, A. Cucinotta, S. Selleri, R. Corradini, and R. Marchelli, "Toward a highly specific DNA biosensor: Pna-modified suspended-core photonic crystal fibers," IEEE J. Sel. Top. Quantum Electron. 16(4), 967-972 (2010). 13. S. C. Warren-Smith, G. Nie, E. P. Schartner, L. A. Salamonsen, and T. M. Monro, "Enzyme activity assays within microstructured optical fibers enabled by automated alignment," Biomed. Opt. Express 3(12), 3304-3313 (2012). Opt. Quantum Electron. 26(3), S261-S272 (1994). 17. C. Bariain, I. R. Matías, F. J. Arregui, and M. Lopez-Amo, "Optical fiber humidity sensor based on a tapered fiber coated with agarose gel," Sensor. Actuat. Biol. Chem. 69, 127-131 (2000). 18. L. C. Shriver-Lake, K. A. Breslin, P. T. Charles, D. W. Conrad, J. P. Golden, and F. S. Ligler, "Detection of tnt in water using an evanescent wave fiber-optic biosensor," Anal. Chem. 67(14), 2431-2435 (1995)

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Photonic crystal fiber based evanescent-wave sensor for detection of biomolecules in aqueous solutions

Abstract: Abstract:We demonstrate evanescent-wave sensing of Cy5-DNA-molecules in an aqueous solution using a photonic crystal fiber. Less than 0.8pL sample volume placed in the holes of the fiber is sufficient for reliable detection.

Cited by 314 publications

References 6 publications

Review of long period fiber gratings written by CO2 laser

Review of long period fiber gratings written by CO2 laser

Photonic crystal fiber long-period gratings for biochemical sensing

Quantification of the fluorescence sensing performance of microstructured optical fibers compared to multi-mode fiber tips

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