Photon–photon coincidences for activity determination: I-125 and other radionuclides

Schrader, H.

doi:10.1016/j.apradiso.2006.02.088

Cited by 15 publications

(13 citation statements)

References 6 publications

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“…(1) the 4πγ -integral counting technique, based on the well-type NaI(Tl) 5 × 5 detector [13,26]; (2) the γ -γ coincidence technique based on two NaI(Tl) 5 × 5 detectors [25] and (3) the Triple-to-Double-Coincidence-Ratio (TDCR) method [14] based on 4πβ-integral counting made by liquid scintillation detectors [11].…”

Section: Cu Activity Measurements At Enea-inmrimentioning

confidence: 99%

64Cu production by 14 MeV neutron beam

Capogni

Capone

Pietropaolo

et al. 2020

JNR

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64Cu is an emerging radionuclide of great interest in personalized nuclear medicine. It is produced by a cyclotron via the reaction 64Ni(p,n)64Cu. This production method increased during the last decades, because small biomedical cyclotrons can be easily installed close to the nuclear medicine department of a hospital. As a matter of fact, 64Ni is a very expensive target material. For this reason, an alternative 64Cu production method was investigated at ENEA by using the quasi-monochromatic 14 MeV fusion neutron beam made available at the Frascati Neutron Generator (FNG) located at the ENEA – Frascati Research Center. In particular, two nuclear reactions were studied: 65Cu(n,2n)64Cu and 64Zn(n,p)64Cu. The radiochemical analysis of the activated samples was performed at the ENEA-NMLNWM laboratory located in ENEA-Casaccia Research Center. The activity measurements were carried out at the ENEA-INMRI, located in the ENEA-Casaccia Research Center, with high metrological level conditions and by assuring their traceability to the 64Cu primary activity standard here developed and maintained. A prediction of the 64Cu production by means of the high-brilliance 14 MeV neutron source named Sorgentina is also discussed.

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Section: Cu Activity Measurements At Enea-inmrimentioning

confidence: 99%

64Cu production by 14 MeV neutron beam

Capogni

Capone

Pietropaolo

et al. 2020

JNR

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“…Sistem koinsidensi γ(NaI) -γ(NaI) merupakan sistem peralatan untuk pengukuran aktivitas secara absolut menggunakan dua buah detektor NaI(Tl) yang diletakkan berhadap-hadapan dan dihubungkan dengan unit koinsidensi [1, [3][4][5][6][7]. Kedua buah detektor yang digunakan sebaiknya memiliki ukuran yang hampir sama, efisiensi intrinsik yang serupa untuk semua jenis foton, sehingga memungkinkan terjadinya cacah koinsidensi [1].…”

Section: B Sistem Koinsidensi γ(Nai) -γ(Nai)unclassified

“…Metode pengukuran aktivitas secara absolut 125 I menggunakan sistem koinsidensi foton-foton, dilakukan dengan dua metode yaitu jarak sumber ke detektor tetap dan variasi jarak sumber ke detektor untuk mendapatkan variasi efisiensi dari masing-masing detektor [3,4,5]. Gerbang saluran gamma ditentukan pada daerah energi foton gamma yang diinginkan [3,4,5]. [6].…”

Section: Pengukuran Aktivitas 125 Iunclassified

“…= Aktivitas 125 I A (129) = Aktivitas 129 I k (125) = konstanta 125 I k (129) = konstanta 129 I Larutan Ag(NO) 3 0,1N digunakan untuk mengikat iodium menjadi endapan AgI. Larutan Catanac (SiO 2 ) digunakan sebagai katalis untuk memperhalus terbentuknya kristal [5 ]. Penyangga sumber dipergunakan plastik polietilen (PE) dengan ketebalan ± 25 µg/cm 3 .…”

Section: Pengukuran Aktivitas 129 Iunclassified

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Standardisasi 129I menggunakan sistem koinsidensi γ(NaI) – γ(NaI) (Halaman 20 s.d. 24)

Pujadi

Wurdiyanto

2014

J. Fis. Indones.

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Telah dilakukan penelitian standardisasi secara absolut radionuklida 129I menggunakan sistem koinsidensi γ(NaI) – γ(NaI) dengan metode perunut. Radionuklida 129I memancarkan radiasi foton yang tidak serempak atau peluruhan bukan cascade, sehingga pengukuran aktivitas menggunakan metode koinsidensi memerlukan radionuklida lain sebagai perunut. 125I digunakan sebagai perunut karena peluruhannya serempak dan mempunyai kesamaan sifat kimia serta kesesuaian daerah energi foton yaitu pada 27 – 40 keV. Sumber 125I dan 129I dalam bentuk cairan Kalium Iodida (KI) dalam H20, masing-masing dipreparasi sendiri-sendiri menjadi cuplikan sumber bentuk titik padat dalam bentuk AgI dengan menambahkan AgNO3. Berat cuplikan ditentukan secara gravimetri, berat masing-masing berkisar antara 10 - 30 mg setiap cuplikan. Tahap pertama dilakukan penentuan aktivitas perunut, menggunakan sistem koinsidensi γ(NaI) – γ(NaI). Pengukuran dilakukan pada daerah puncak energi gamma tunggal 13 – 42 keV (single peak). Tahap kedua dilakukan pengukuran sumber campuran 129I dan 125I (sandwiched), menggunakan peralatan dan seting yang sama dengan kondisi pengukuran aktivitas perunut. Hasil pengukuran aktivitas 129I menggunakan perunut 125I, diperoleh aktivitas sebesar 998,56 ± 1,01% Bq/gr dengan waktu acuan 1 agustus 2012. Nilai aktivitas 129I tersebut bersesuaian dengan hasil pengukuran aktivitas PTB – Jerman menggunakan kamar pengionan-4πγ, dengan perbedaan 0,14%.

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“…The 4π γ-γ coincidence technique [14], making use of two high-efficiency NaI(Tl) 5 ×5 cylindrical detectors (see fig. 9), was selected to measure with high precision and accuracy the 64 Cu activity.…”

mentioning

confidence: 99%

The (64)Zn-based production route to (64)Cu β(±) emitter using accelerator-driven 14 MeV fusion neutrons

Capogni¹,

Capone²,

Colangeli³

et al. 2022

EPL

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The development of personalized medicine is important to avoid unnecessary and expensive treatments. The theranostic approach is an established tool for specific molecular targeting, both for diagnostics and therapy. Radionuclides used for theranostic radiopharmaceuticals are typically produced in nuclear fission reactors or bio-medical cyclotrons. Here, an alternative route for producing an emerging theranostic radionuclide, namely 64Cu, is investigated by using 14 MeV fusion neutrons produced by the Frascati Neutron Generator (FNG) at the ENEA Frascati Research Centre. Samples of zinc (natural and 64Zn enriched) were irradiated and characterized, in turn being measured at high-level metrological conditions, at the Radioactivity Laboratory of ENEA-INMRI located in Casaccia Research Centre. The results achieved in the experiments are presented and compared to those obtained by Monte Carlo simulations and previously published experimental data.

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Photon–photon coincidences for activity determination: I-125 and other radionuclides

Cited by 15 publications

References 6 publications

64Cu production by 14 MeV neutron beam

64Cu production by 14 MeV neutron beam

Standardisasi 129I menggunakan sistem koinsidensi γ(NaI) – γ(NaI) (Halaman 20 s.d. 24)

The (64)Zn-based production route to (64)Cu β(±) emitter using accelerator-driven 14 MeV fusion neutrons

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