Photon emission from normal and tumor human tissues

Grasso, Francesco; Grillo, Calogero; Musumeci, F.; Triglia, A.; Rodolico, Giuseppe; Cammisuli, F; Rinzivillo, Calogero; Fragati, G.; Santuccio, A.; Rodolico, Margherita

doi:10.1007/bf01923595

Cited by 39 publications

(15 citation statements)

References 8 publications

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“…In cell studies, experimental data pointed to higher primary and secondary emissions of tumor cells compared to normal parental cells [9]–[13]. The data have been confirmed utilizing normal and tumor tissue [14]. The use of two-dimensional imaging plus photon counting of ultra-weak photon emission (UPE) from a transplanted bladder cancer into the feet of nude mice was reported in 1995 [15].…”

Section: Introductionmentioning

confidence: 94%

Imaging of Ultra-Weak Photon Emission in a Rheumatoid Arthritis Mouse Model

et al. 2013

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Ultra-weak photon emission (UPE) of a living system received scientific attention because of its potential for monitoring increased levels of reactive oxygen species (ROS) in the pathogenesis of rheumatoid arthritis (RA). In this study, a highly sensitive cryogenic charge-coupled device (CCD) camera was used to monitor in a RA mouse model the photon emission both without and with luminol. For that purpose, arthritis was induced in mice utilizing a repeated co-administration of type II collagen with lipopolysaccharide. Quantitative imaging of ultra-weak photon emission of the front and back paws of the animals was initiated 70 days after the first injection. All of the animals were measured once without luminol and once again immediately after luminol injection. Data illustrated a higher UPE intensity after initiating arthritis by CII-injection of the animals. The increase in UPE intensity was measured with and without using luminol indicating that this imaging technology may be useful for the future study of human RA.

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Section: Introductionmentioning

confidence: 94%

Imaging of Ultra-Weak Photon Emission in a Rheumatoid Arthritis Mouse Model

et al. 2013

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“…melanin) that absorbs 80-90% of the re-emitted photons. As most recently reported by Grasso et al 30 , normal cells emit significantly less biophotons than cells from cancer tissue. Thus, returning to Dicke's theory 27 , normal cells have a greater capacity for subradiance the closer they are together, while tumour cells show the opposite behaviour, that is, the loss of subradiance.…”

Section: *Ct = Cholera Toxinmentioning

confidence: 76%

Biophoton Re-emission Studies in Carcinogenic Mouse Melanoma Cells

Niggli¹

1992

Recent Advances in Biophoton Research and Its Applications

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Practically all cells emit light at a steady rate from a few photons per cell per day to several photons per cell per second, which is readily detected with a sensitive photomultiplier placed with the cells in a dark chamber. It is widely accepted that at least a part of the emitted light results from radical reactions, but chromatin has also been suggested to be the source of this ultra-weak radiation in living cells. Although the emission of this light is very low in mammalian cells, recentstudies have demonstrated that the nature of this radiation can also be studied as rescattered emission after a brief illumination with an ordinary light source. Using this experimental design, we have investigated the contribution of nuclei to the ultra-weak photon re-emission in Cloudman S 91 mouse melanoma cells. In all experiments reported here, it turns out that the nuclei make the greatest, if not the entire contribution to this radiation indicating that chromatin acts as a photon store emitting partially coherent light which may be involved in the control of gene activity, cell metabolism and cell communication. 231 Recent Advances in Biophoton Research and Its Applications Downloaded from www.worldscientific.com by UNIVERSITY OF BIRMINGHAM LIBRARY -INFORMATION SERVICES on 03/21/15. For personal use only.

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“…The specimens studied included cases ofcolon cancers (33), gastric malignancies (18) and breast cancers (12). Every time when it was possible three measurements were carried out for the samples taken from a centre of the tumour, from a lransition zone between the tumour and a healthy tissue and from area most distant from the tumour i.e.…”

Section: Resultsmentioning

confidence: 99%

In vitro measurements of ultraweak luminescence of human malignant tumors and healthy tissues

Chwirot

Jedrzejczyk

et al. 2001

SPIE Proceedings

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In vitro measurements oflevels ofultraweak luminescence were carried out using healthy and malignant tissues obtained from 63 patients undergoing surgical operations for cancers of colon, stomach and breast. The results obtained support recent reports that there is a difference in mean intensities of the ultraweak luminescence emitted form healthy and malignant tissues. This work demonstrates, however, that because of a large scatter among the intensities detected for samples obtained from different patients the differences found for the mean intensities cannot serve as a parameter for differentiating between the malignant and normal human tissues.

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Photon emission from normal and tumor human tissues

Cited by 39 publications

References 8 publications

Imaging of Ultra-Weak Photon Emission in a Rheumatoid Arthritis Mouse Model

Imaging of Ultra-Weak Photon Emission in a Rheumatoid Arthritis Mouse Model

Biophoton Re-emission Studies in Carcinogenic Mouse Melanoma Cells

In vitro measurements of ultraweak luminescence of human malignant tumors and healthy tissues

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