Photon-counting gamma camera based on an electron-multiplying CCD

Vree, G.A. de; Westra, Albert H.; Moody, Ian; Have, Frans van der; Ligtvoet, K.M.; Beekman, Freek J.

doi:10.1109/tns.2005.851443

Cited by 64 publications

(52 citation statements)

References 20 publications

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“…Detectors with resolutions down to 0.05 mm have been developed recently (e.g. de Vree et al 2005, Meng 2006, Nagarkar et al 2006. At present, however, these detectors have rather low capture efficiencies.…”

Section: Discussionmentioning

confidence: 99%

Theoretical analysis of full-ring multi-pinhole brain SPECT

2009

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Presently used clinical brain SPECT suffers from limited spatio-temporal resolution. Here we investigate the feasibility of high-resolution and highsensitivity full-ring multi-pinhole brain SPECT (MP-SPECT). Using an analytical model we optimized pinhole-detector geometries of MP-SPECT for different detector intrinsic resolutions R i . System resolution and sensitivity of optimized MP-SPECT were compared to conventional clinical SPECT. The comparison of the system resolution of different systems was done at matched sensitivity, which was achieved by tuning pinhole diameters. Similarly, sensitivities were compared at matched system resolution. For MP-SPECT that uses detectors with intrinsic resolutions of 4 mm > R i 0.5 mm a sensitivity can be achieved that is 6.0 times higher than the sensitivity of conventional dualhead SPECT systems with parallel-hole collimators (DualPar), while system resolution can be improved by a factor of 2.4. To achieve these improvements a large detector-to-collimator distance is needed. In contrast, for detectors with intrinsic resolutions < 0.2 mm, it is beneficial to place the detectors close to the pinholes, resulting in a high number of de-magnified projections. For a detector intrinsic resolution of 0.05 mm, a 14.5-fold improvement in sensitivity and a 3.8-fold improvement in system resolution compared to DualPar is predicted. Furthermore, we found that for optimized MP-SPECT the sensitivity scales proportionally to system resolution squared, with the proportionality constant depending on R i . From our sensitivity-system resolution trade-off equations we deduced that MP-SPECT with an ideal detector (R i → 0) can have a system resolution that is 2.0 times better than optimized MP-SPECT with a conventional detector (R i 3 mm). The high performance of optimized MP-SPECT may open up completely new molecular imaging applications.

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Section: Discussionmentioning

confidence: 99%

Theoretical analysis of full-ring multi-pinhole brain SPECT

2009

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“…NEMA NU1-2007 [10] states the "pixel size should be less than or equal to 0.1 FWHM", that is _0.3 mm for a 540 mm diameter gamma camera. To achieve the specified "pixel size" the analogue to digital conversion gain is increased perpendicular to the line source for each orthogonal axis simultaneously, and the "zoomed" portion of the field of view is imaged.SFOV cameras have reported values of spatial resolution of less than 1.0 mm [15,16,17,18], suggesting that the NEMA "pixel size" should be at most 0.1 mm (equal to 0.1 FWHM). For a typical LFOV resolution of 3 mm, the use of a 0.5 mm line source will not have a large effect on measured resolution; at submillimeter resolution, however, the width of the same source becomes significant.…”

Section: Intrinsic Spatial Resolutionmentioning

confidence: 99%

Assessment of Spatial Resolution on SPECT using Image Processing

Ahmed¹,

Alameen²,

Khairi³

et al. 2017

IOSR JAP

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“…EMCCDs have higher quantum efficiencies (up to 95% with back-illumination) and broader spectral responses (400 to 900 nm) when compared to PMTs. Also, intrinsic resolutions less than 100 µm have been shown for EMCCD based gamma cameras [25], [26]. The most important characteristic of an EMCCD is the improved low light level signal-to-noise ratio (SNR) when compared to conventional CCDs.…”

Section: Emccd Sensitivitymentioning

confidence: 99%

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

Antich¹,

Constantinescu²,

Lewis³

et al. 2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE 01-05-20072. REPORT TYPE Final DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERThe University of Texas Southwestern Medical Center at Dallas Dallas, TX 75390-9105 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white. ABSTRACTThe goal of our project is to image the processes that occur during tumor growth and metastatic spread or regression including the fate of minimal residual disease. To do so it is necessary to test the limits of sensitivity of newly developed techniques: our technical goal is to develop integrated light emission and single photon emission tomography. We have made substantial progress in our techniques for the detection of metastases. We have demonstrated our capability to detect millimeter or sub-millimeter metastases in mice by light emission. To this end we have used Light Emission Tomography (LET), a technique based on bioluminescence of cancer cells infected with luciferase, to detect metastases in the lung and head. We have begun assessment of perfusion using fluorescence imaging. In addition, our technological focus is on the simultaneous use of Single-photon Emission Computed Tomography (SPECT), and to this end we have developed a new form of micro-SPECT based on cooled, electron-multiplied Charge-Coupled Devices (EMCCDs) with which we are performing ongoing imaging experiments. We have also collaborated on the assessment of a new, promising SPECT imaging agent, clioquinol or Iodinated hydroxyquinoline. We will use bioluminescence imaging to test if clioquinol imaging detects areas where tumor cells proliferate and establish metastases and to identify the relative times at which the images first appear. SUBJECT TERMS INTRODUCTIONBecause growth of very small tumors has not been s...

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Photon-counting gamma camera based on an electron-multiplying CCD

Cited by 64 publications

References 20 publications

Theoretical analysis of full-ring multi-pinhole brain SPECT

Theoretical analysis of full-ring multi-pinhole brain SPECT

Assessment of Spatial Resolution on SPECT using Image Processing

Investigation of Metastatic Breast Tumor Heterogeneity and Progression Using Dual Optical/SPECT Imaging

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