Photon-Counting CT

Mannil, Manoj; Hickethier, Tilman; Spiczak, Jochen von; Baer, Matthias; Henning, André; Hertel, Madeleine; Schmidt, Bernhard; Flohr, Thomas; Maintz, David; Alkadhi, Hatem

doi:10.1097/rli.0000000000000420

Cited by 103 publications

(79 citation statements)

References 29 publications

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“…This is mostly because of the smaller pixel size of PCDs compared with that of energy integrating detectors, which are used in typical CT scanners. 2,13 Altogether, these results suggest that SPCCT should have a tumor identification potential beyond current detection. 27 This will have to be tested in an animal model of peritoneal carcinomatosis by simultaneously injecting gadolinium IP to highlight PMs via negative contrast and iodine IV to improve the contrast resolution between normal tissue and PM enhancement.…”

Section: Discussionmentioning

confidence: 79%

“…Indeed, photon-counting detectors (PCDs) allow an exact physical representation of pixel values, with quantitative information processed by the SPCCT system from the spectrum transmitted through the subject. 2 Moreover, PCDs have higher spatial resolution that allows differentiation of smaller structures, such as parenchymal arteries, or very small lesions with a size below the detection limit of standard CT. 2,13…”

mentioning

confidence: 99%

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Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging

Si‐Mohamed¹,

Thivolet²,

Bonnot³

et al. 2018

Invest Radiol

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Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging

Si‐Mohamed¹,

Thivolet²,

Bonnot³

et al. 2018

Invest Radiol

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“…However, the measured width of the struts, which was measured approximately 30% more accurately on the SPCCT system than on the other systems, reflects the improved spatial resolution of the SPCCT 7,13,14 . These results are in agreement with the very recent study of Mannil and colleagues, who found a 28.8% increase in intra stent luminal diameter when comparing a photon counting detector (PCD) to a conventional energy integrating detector (EID) 13 . To be noted that in our study, different slice thicknesses were used between the SPCCT and the IQon and B64 system.…”

Section: Discussionmentioning

confidence: 88%

Feasibility of improving vascular imaging in the presence of metallic stents using spectral photon counting CT and K-edge imaging

Sigovan¹,

Si‐Mohamed²,

Bar-Ness³

et al. 2019

Sci Rep

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Correct visualization of the vascular lumen is impaired in standard computed tomography (CT) because of blooming artifacts, increase of apparent size, induced by metallic stents and vascular calcifications. Recently, due to the introduction of photon-counting detectors in the X-ray imaging field, a new prototype spectral photon-counting CT (SPCCT) based on a modified clinical CT system has been tested in a feasibility study for improving vascular lumen delineation and visualization of coronary stent architecture. Coronary stents of different metal composition were deployed inside plastic tubes containing hydroxyapatite spheres to simulate vascular calcifications and in the abdominal aorta of one New Zealand White (NZW) rabbit. Imaging was performed with an SPCCT prototype, a dual-energy CT system, and a conventional 64-channel CT system (B64). We found the apparent widths of the stents significantly smaller on SPCCT than on the other two systems in vitro (p < 0.01), thus closer to the true size. Consequently, the intra-stent lumen was significantly larger on SPCCT (p < 0.01). In conclusion, owing to the increased spatial resolution of SPCCT, improved lumen visualization and delineation of stent metallic mesh is possible compared to dual-energy and conventional CT.

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“…Another significant benefit of spectral imaging is the possibility to measure the absolute concentration of contrast agents such as gadolinium, iodine, or gold 13,20–22 . Finally, the high spatial resolution of PCDs enables the differentiation of small structures like parenchymal arteries or lesions with sizes below the detection limit of conventional CT 7,23,24 . Accordingly, Mullner et al .…”

Section: Introductionmentioning

confidence: 99%

Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol

Si‐Mohamed

Tatard-Leitman

Laugerette

et al. 2019

Sci Rep

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Diagnostic imaging of hepatocellular carcinoma (HCC) requires a liver CT or MRI multiphase acquisition protocol. Patients would benefit from a high-resolution imaging method capable of performing multi-phase imaging in a single acquisition without an increase in radiation dose. Spectral Photon-Counting Computed Tomography (SPCCT) has recently emerged as a novel and promising imaging modality in the field of diagnostic radiology. SPCCT is able to distinguish between two contrast agents referred to as multicolor imaging because, when measuring in three or more energy regimes, it can detect and quantify elements with a K-edge in the diagnostic energy range. Based on this capability, we tested the feasibility of a dual-contrast multi-phase liver imaging protocol via the use of iodinated and gadolinated contrast agents on four healthy New Zealand White (NZW) rabbits. To perform a dual-contrast protocol, we injected the agents at different times so that the first contrast agent visualized the portal phase and the second the arterial phase, both of which are mandatory for liver lesion characterization. We demonstrated a sensitive discrimination and quantification of gadolinium within the arteries and iodine within the liver parenchyma. In the hepatic artery, the concentration of gadolinium was much higher than iodine (8.5 ± 3.9 mg/mL versus 0.7 ± 0.1 mg/mL) contrary to the concentrations found in the liver parenchyma (0.5 ± 0.3 mg/mL versus 4.2 ± 0.3 mg/mL). In conclusion, our results confirm that SPCCT allows in-vivo dual contrast qualitative and quantitative multi-phase liver imaging in a single acquisition.

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Photon-Counting CT

Abstract: At matched CT scan protocol settings and identical image reconstruction parameters, the PCD yields superior in-stent lumen delineation of coronary artery stents as compared with conventional EID arrays.

Cited by 103 publications

References 29 publications

Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging

Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging

Feasibility of improving vascular imaging in the presence of metallic stents using spectral photon counting CT and K-edge imaging

Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol

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