Photomodulation of Fluorescent Upconverting Nanoparticle Markers in Live Organisms by Using Molecular Switches

Boyer, John‐Christopher; Carling, Carl-Johan; Chua, Shu Yi; Wilson, Danielle; Johnsen, Bob; Baillie, David L.; Branda, Neil R.

doi:10.1002/chem.201103767

Cited by 64 publications

(65 citation statements)

References 31 publications

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“…Although recently several solutions, such as upconversion nanoparticles (UCNPs), 23,25,79 metal to ligand charge transfer (MLCT) 9b,22,80 and multi-photon excitation processes, 21,81 have been proposed, they are still in their infancy. Nowadays, most efforts have been devoted to the construction of functional bio-materials with photo-reversible fragments.…”

Section: Discussionmentioning

confidence: 99%

Taking orders from light: progress in photochromic bio-materials

2014

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Photochromic materials are a family of compounds which undergo photo-reversible transformations between two different isomers with distinct physical and chemical properties. Most smart photochromic materials have been exploited in research areas such as electro-optical functional materials, while recently their applications have extended to novel bio-materials. Biological systems, such as tissue/ cellular imaging, nucleotides, peptides, ion channels, etc., have emerged as a revolutionary research frontier for photochromic materials since both covalent coupling and non-covalent interactions with bio-molecules have been achieved. This review commences with a brief description of exciting progress in this field, and describes strategies for using photochromic functional molecules from bio-sensing and cell imaging to optical manipulation of bio-macromolecules (nucleotides, peptides, ion channels, GFP, etc.). Further development of these photo-switches as well as remaining challenges are also discussed and put in prospect.

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Section: Discussionmentioning

confidence: 99%

Taking orders from light: progress in photochromic bio-materials

2014

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“…Photochromic nanoparticles may be created by combining upconversion nanoparticles containing crystalline NaYF 4 doped with trivalent lanthanide ions [98][99][100]. As a fluopophore, monodisperse rare-earthdoped upconversion nanophosphors β-NaYF 4 :Yb,Er (λ max =540 and 650 nm) were used together with pho-…”

Section: Doped Upconversion Nanoparticlesmentioning

confidence: 99%

“…69 with the alkyne group necessary for "click" chemistry and a methoxypolyethylene glycol chain providing water dispersibility and eventual biocompatibility were used for photomodulation of green fluorescence (λ = 510 -560 nm) in living organisms [100]. …”

Section: Scheme 68mentioning

confidence: 99%

Nanophotochromism

Barachevsky¹

2015

Organic Photonics and Photovoltaics

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Abstract:The review presents the state-of-the-art analysis of investigations in the field of a new line of research of photochromism -nanophotochromism. The design, properties, and possible applications of photochromic nanoparticles prepared by different methods with the use of photochromic substances (aggregates, host-guest, and polymer systems, solid nanoparticles) as well as core-shell photochromic nanostructures based on polymers, silica, quantum dots, doped upconversion nanocrystals, and Ag, Au, etc. nanoparticles have been reviewed. Keywords: photochromism; photochromic nanoparticles; core-shell photochromic nanoparticles design; photoswitching; aggregates; polymer systems, host-guest systems IntroductionPhotochromism is a very important phenomenon for different applications in photonics. The applications are based on reversible phototransformations of photochromic compounds between two states and changes of their properties that accompany these transformations At present, systems and materials containing photochromic nanopatricles have become highly significant. Among these are nanodimensional particles of photochromic substances, including aggregates, and coreshell systems. As a core, inorganic nanoparticles of gold, silver, metal oxides, quantum dots (QD), and also polymeric nanoparticles are used. The shell consists of photochromic molecules or their aggregates connected to a core surface either chemically or physically. Photochromic nanoparticles with photocontrolled fluorescence arouse a special interest because the fluorescence technique is becoming a leading strategy in biological diagnosis, imaging, and detection applications. This paper is a state-of-the-art review which presents results of studying photochromic nanoparticles including author's own data. The results of earlier research are also surveyed in some other reviews [1][2][3][4][5][6][7][8][9][10][11][12][13]. Photochromic nanoparticles:properties and applications Nanoparticles based on photochromic substances AggregatesThe most known photochromic nanoparticles are aggregates of photochromic organic compounds [14]. These compounds experience reversible photoinduced transformations between two states, Sch. 1A and Sch. 1B. Scheme 1The photoinduced colored merocyanine form B absorbing visible irradiation is formed from a colorless form A as a result of photodissociation of the -C-O-bond of the pyran heterocycle under UV radiation, and this is followed by spontaneous isomerization of the cis-form to the trans one. The colored form B can be converted back to the initial colorless form A upon absorption of visible light or spontaneously during the dark relaxation, which is accelerated by heating.The J-aggregates of nitro-substituted indoline spiropyrans Sch. 2 with long alkyl substituents are of special interest [15].The narrow absorption bands of J-aggregates of these photochromic compounds (Fig. 1) made it possible prepare a specimen of the multilayered optical disk providing freUnauthenticated Download

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“…Hence, UCNPs have received significant attention for applications in long-wavelength photolysis. 32,33 This developed material has been used to photoactivate small molecules, such as luminophore, 33,34 folic acid, 35 cisplatin derivatives, 36,37 DNA/siRNA, 38,39 and to trigger controlled-release systems, such as porous silica, 32,40,41 copolymer vesicles, 42,43 and hollow particles. 44,45 These studies laid important ground for UCNP-assisted photoactivation techniques.…”

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confidence: 99%

Construction of a Near-Infrared-Activatable Enzyme Platform To Remotely Trigger Intracellular Signal Transduction Using an Upconversion Nanoparticle

et al. 2015

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Photoactivatable (caged) bioeffectors provide a way to remotely trigger or disable biochemical pathways in living organisms at a desired time and location with a pulse of light (uncaging), but the phototoxicity of ultraviolet (UV) often limits its application. In this study, we have demonstrated the near-infrared (NIR) photoactivatable enzyme platform using protein kinase A (PKA), an important enzyme in cell biology. We successfully photoactivated PKA using NIR to phosphorylate its substrate, and this induced a downstream cellular response in living cells with high spatiotemporal resolution. In addition, this system allows NIR to selectively activate the caged enzyme immobilized on the nanoparticle surface without activating other caged proteins in the cytosol. This NIR-responsive enzyme-nanoparticle system provides an innovative approach to remote-control proteins and enzymes, which can be used by researchers who need to avoid direct UV irradiation or use UV as a secondary channel to turn on a bioeffector.

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Photomodulation of Fluorescent Upconverting Nanoparticle Markers in Live Organisms by Using Molecular Switches

Cited by 64 publications

References 31 publications

Taking orders from light: progress in photochromic bio-materials

Taking orders from light: progress in photochromic bio-materials

Nanophotochromism

Construction of a Near-Infrared-Activatable Enzyme Platform To Remotely Trigger Intracellular Signal Transduction Using an Upconversion Nanoparticle

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