Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants

Hu, Yingxue; Zou, Wenyue; Julita, Villy; Ramanathan, Rajesh; Tabor, Rico F.; Nixon-Luke, Reece; Bryant, Gary; Bansal, Vipul; Wilkinson, Brendan L.

doi:10.1039/c6sc03020c

Cited by 45 publications

(37 citation statements)

References 60 publications

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“…[70,79] Besides synthetic polymers, antifouling properties have also been obtained with polysaccharide coatings that decreased bacteria adhesion to a titanium surface up to 96% after 90 min of contact, [50] and agarose crosslinked on a solid support reduced the adhesion of proteins to device surfaces by >90%. [92] The physical property of the coating compound is sometimes coupled to antimicrobial effects from the chemical nature of the polymer; for example, a mixture of hyaluronic acid and chitosan [93] or poly(N-hydroxyethylacrylamide) crosslinked with salicylate [94] decreased bacteria adhesion, and also inhibited their proliferation. [92] The physical property of the coating compound is sometimes coupled to antimicrobial effects from the chemical nature of the polymer; for example, a mixture of hyaluronic acid and chitosan [93] or poly(N-hydroxyethylacrylamide) crosslinked with salicylate [94] decreased bacteria adhesion, and also inhibited their proliferation.…”

Section: Polymer-coated Surfacesmentioning

confidence: 99%

Nanoscience‐Based Strategies to Engineer Antimicrobial Surfaces

et al. 2018

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Microbial contamination and biofilm formation of medical devices is a major issue associated with medical complications and increased costs. Consequently, there is a growing need for novel strategies and exploitation of nanoscience‐based technologies to reduce the interaction of bacteria and microbes with synthetic surfaces. This article focuses on surfaces that are nanostructured, have functional coatings, and generate or release antimicrobial compounds, including “smart surfaces” producing antibiotics on demand. Key requirements for successful antimicrobial surfaces including biocompatibility, mechanical stability, durability, and efficiency are discussed and illustrated with examples of the recent literature. Various nanoscience‐based technologies are described along with new concepts, their advantages, and remaining open questions. Although at an early stage of research, nanoscience‐based strategies for creating antimicrobial surfaces have the advantage of acting at the molecular level, potentially making them more efficient under specific conditions. Moreover, the interface can be fine tuned and specific interactions that depend on the location of the device can be addressed. Finally, remaining important challenges are identified: improvement of the efficacy for long‐term use, extension of the application range to a large spectrum of bacteria, standardized evaluation assays, and combination of passive and active approaches in a single surface to produce multifunctional surfaces.

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Section: Polymer-coated Surfacesmentioning

confidence: 99%

Nanoscience‐Based Strategies to Engineer Antimicrobial Surfaces

et al. 2018

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“…Their numerous technological and bio-related applications emerge due to the UV/Vis light-induced reversible trans-cis-trans isomerization. They can be employed as containers with photosensitive lock for delivery and release of drugs into cells [ 16 ], in biofilms, photoresponsive DNA thermotropic liquid crystals [ 17 ], for photoregulated antibacterial activity, and biological photocontrol [ 17 , 18 , 19 , 20 ]. The light-controlled reversible DNA packaging is well studied when using azobenzene-containing surfactants [ 1 , 5 , 11 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles

et al. 2018

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Cationic azobenzene-containing surfactants are capable of condensing DNA in solution with formation of nanosized particles that can be employed in gene delivery. The ratio of surfactant/DNA concentration and solution ionic strength determines the result of DNA-surfactant interaction: Complexes with a micelle-like surfactant associates on DNA, which induces DNA shrinkage, DNA precipitation or DNA condensation with the emergence of nanosized particles. UV and fluorescence spectroscopy, low gradient viscometry and flow birefringence methods were employed to investigate DNA-surfactant and surfactant-surfactant interaction at different NaCl concentrations, [NaCl]. It was observed that [NaCl] (or the Debye screening radius) determines the surfactant-surfactant interaction in solutions without DNA. Monomers, micelles and non-micellar associates of azobenzene-containing surfactants with head-to-tail orientation of molecules were distinguished due to the features of their absorption spectra. The novel data enabled us to conclude that exactly the type of associates (together with the concentration of components) determines the result of DNA-surfactant interaction. Predomination of head-to-tail associates at 0.01 M < [NaCl] < 0.5 M induces DNA aggregation and in some cases DNA precipitation. High NaCl concentration (higher than 0.8 M) prevents electrostatic attraction of surfactants to DNA phosphates for complex formation. DAPI dye luminescence in solutions with DNA-surfactant complexes shows that surfactant tails overlap the DNA minor groove. The addition of di- and trivalent metal ions before and after the surfactant binding to DNA indicate that the bound surfactant molecules are located on DNA in islets.

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“…[2][3][4][5] These new surfactants need to be developed using a sustainable approach and should contain biocompatible functional groups capable of undergoing biodegradation aer use. 6,7 Using renewable raw feedstock such as oleo-chemicals, 8,9 carbohydrates, 10,11 amino acids 12,13 etc. derived from natural sources for manufacturing surfactants will check the environmental issues since these surfactants aer degradation will only release back corresponding carbon to environment, which has been previously consumed by plant for making feedstock.…”

Section: Introductionmentioning

confidence: 99%