Photolysis of Vitamin B12

Demerre, Leon J.; Wilson, Catherine E.

doi:10.1002/jps.3030450302

Cited by 17 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rates of destruction of cyanocobalamin in neutral aqueous solutions when exposed to various light sources have been reported by DeMerre and Wilson (43). Below 300 foot candles no destruction is noticeable.…”

Section: Degradation Studiesmentioning

confidence: 90%

Vitamins in Pharmaceutical Formulations

Deritter

1982

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Degradation Studiesmentioning

confidence: 90%

Vitamins in Pharmaceutical Formulations

Deritter

1982

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Photochemical mechanisms of solid-state reactions also have been reviewed (l), but not from the viewpoint of stabilization. Because of the complexity of photochemical reactions, there has been very little reported on the photostability of solid dosage forms (2)(3)(4)(5)(6)(7)(8)(9). Ubidecarenone [2,3-dimethoxy-5-methyl-6-decaprenylbenzoquinone (I)], a lipid-soluble benzoquinone derivative with a melting point of -48' (lo), is widely used in Japan for the treatment of angina.…”

mentioning

confidence: 99%

Photostability of Solid-State Ubidecarenone at Ordinary and Elevated Temperatures under Exaggerated UV Irradiation

Matsuda

Masahara

1983

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…In this pH range, the H 2 OCbl + is the prevalent form, however at neutral pH OHCbl is the main species. [155]. Since then, this field has been updated by numerous publications and is still being researched [156][157][158][159][160][161][162].…”

Section: Ph Of the Solutionmentioning

confidence: 99%

Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

et al. 2022

View full text Add to dashboard Cite

Vitamin B12, also known as the anti-pernicious anemia factor, is an essential micronutrient totally dependent on dietary sources that is commonly integrated with food supplements. Four vitamin B12 forms—cyanocobalamin, hydroxocobalamin, 5′-deoxyadenosylcobalamin, and methylcobalamin—are currently used for supplementation and, here, we provide an overview of their biochemical role, bioavailability, and efficacy in different dosage forms. Since the effective quantity of vitamin B12 depends on the stability of the different forms, we further provide a review of their main reactivity and stability under exposure to various environmental factors (e.g., temperature, pH, light) and the presence of some typical interacting compounds (oxidants, reductants, and other water-soluble vitamins). Further, we explore how the manufacturing process and storage affect B12 stability in foods, food supplements, and medicines and provide a summary of the data published to date on the content-related quality of vitamin B12 products on the market. We also provide an overview of the approaches toward their stabilization, including minimization of the destabilizing factors, addition of proper stabilizers, or application of some (innovative) technological processes that could be implemented and contribute to the production of high-quality vitamin B12 products.

show abstract

Photolysis of Vitamin B12

Cited by 17 publications

References 0 publications

Vitamins in Pharmaceutical Formulations

Vitamins in Pharmaceutical Formulations

Photostability of Solid-State Ubidecarenone at Ordinary and Elevated Temperatures under Exaggerated UV Irradiation

Vitamin B12 in Foods, Food Supplements, and Medicines—A Review of Its Role and Properties with a Focus on Its Stability

Contact Info

Product

Resources

About