Photolocalized Varicella

Castrow, Fred F.

doi:10.1001/archderm.1973.01620190092026

Cited by 27 publications

(19 citation statements)

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“…Honing of other viral exanthems to sites of inflammation or cutaneous injury has also been described, e.g. localization of varicella to an area of sunburn 23 or diaper dermatitis, 24 and accentuation of CV-A16 HFMD in an area of diaper dermatitis. 24 Viremia in the setting of increased vascular permeability at sites of inflammation may underlie this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection

Lott

Liu

Landry

et al. 2013

Journal of the American Academy of Dermatology

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Background Hand, foot, and mouth disease (HFMD) is an acute viral illness commonly caused by coxsackievirus A16 (CV-A16) and enterovirus 71 infections. Recently, atypical HFMD has been reported in association with CV-A6, an uncommon enterovirus strain. Objective To describe the clinical features of atypical HFMD associated with CV-A6 infection and its diagnostic laboratory evaluation. Methods Patients presenting to our institution with history and examination suggestive of atypical HFMD from January 2012 to July 2012 were identified. Morphology and distribution of mucocutaneous lesions were recorded. Enterovirus infection was assessed by reverse transcriptase polymerase chain reaction of biologic specimens. Enterovirus type was determined by viral capsid protein 1 gene sequencing. Results Two adults and 3 children with atypical HFMD were identified. Four of 5 patients exhibited widespread cutaneous lesions. In 2 patients with a prior history of atopic dermatitis, accentuation in areas of dermatitis was noted. Associated systemic symptoms prompted 4 of 5 patients to seek emergency care, and both adults were hospitalized for diagnostic evaluation. Infection with CV-A6 was confirmed in all patients. Limitations This study is a case series from a single institution. Conclusion Consideration of the expanded range of cutaneous findings in atypical HFMD caused by CV-A6 infection may assist clinicians in diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection

Lott

Liu

Landry

et al. 2013

Journal of the American Academy of Dermatology

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“…The reason for the inter‐subject variation is yet unknown. In varicella, it is known that eruptions sometimes localize in sunburned areas, called photolocalized varicella . In this photolocalized varicella, vesicles appear earlier and more in sunburned areas.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster

Ihara

Miyachi

Imafuku

2017

The Journal of Dermatology

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Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus-specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P < 0.0001). Patients with high immunoglobulin G and complement fixation titers were immunoglobulin M-negative. Unexpectedly, immunoglobulin G and complement fixation titers showed large inter-subject variation, and were only weakly correlated with onset-measurement time lapse. Patients with consecutive tests tended to show increasing immunoglobulin G and complement fixation titers. Our data suggest that herpes zoster preferentially occurs in patients with low immunoglobulin G and complement fixation titers, and subsequently causes antibody elevation. However, the timing of elevation varies and can be as late as 10 days after zoster. The large variation in antibody titer over the time from onset to testing suggests that some mechanism exists that resists the local breakthrough of virus in the skin, and so delays the onset of blisters.

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“…Sunlight has long been recognized as an important aggravating or precipating factor in viral diseases (1). It is also well known that sun exposure may produce local exacerbation or acceleration of a viral exanthem in the same way that other physical (pressure, trauma, maceration, cold) or chemical agents do (2).…”

mentioning

confidence: 99%

“…It is also well known that sun exposure may produce local exacerbation or acceleration of a viral exanthem in the same way that other physical (pressure, trauma, maceration, cold) or chemical agents do (2). Little has been written, however, about localization of the lesions of viral exanthems to areas previously sunburned or suntanned, for which the term photodistribution or photolocalization has been suggested (1). A review of the literature revealed only a few reports (1)(2)(3)(4).…”

mentioning

confidence: 99%

“…Little has been written, however, about localization of the lesions of viral exanthems to areas previously sunburned or suntanned, for which the term photodistribution or photolocalization has been suggested (1). A review of the literature revealed only a few reports (1)(2)(3)(4). We saw two patients with varicella showing photodistribution of the lesions on sunburned and suntanned skin.…”

mentioning

confidence: 99%

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