Photokilling cancer cells using highly cell-specific antibody–TiO2 bioconjugates and electroporation

Xu, Juan; Sun, Yi; Huang, Jianye; Chen, Chunmei; Liu, Guoyuan; Jiang, Yan; Zhao, Yaohua; Jiang, Zhiyu

doi:10.1016/j.bioelechem.2007.06.001

Cited by 127 publications

(100 citation statements)

References 18 publications

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“…The photocatalytic effect of TiO 2 has been applied to cancer treatment [20][21][22][23][24][25], and US irradiation is an alternative energy source for TiO 2 [26][27][28]. Furthermore, toxicological examinations have shown that the TiO 2 nanoparticle is basically nontoxic for experimental cells or animals [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Yamaguchi

Kobayashi

Narita

et al. 2011

Ultrasonics Sonochemistry

135

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Sonodynamic therapy is expected to be a novel therapeutic strategy for malignant gliomas. The titanium dioxide (TiO 2 ) nanoparticle, a photosensitizer, can be activated by ultrasound. In this study, by using water-dispersed TiO 2 nanoparticles, an in vitro comparison was made between the photodynamic and sonodynamic damages on U251human glioblastoma cell lines. Water-dispersed TiO 2 nanoparticles were constructed by the adsorption of chemically modified polyethylene glycole (PEG) on the TiO 2 surface (TiO 2 /PEG). To evaluate cytotoxicity, U251 monolayer cells were incubated in culture medium including 100 μg/ml of TiO 2 /PEG for three hours and subsequently irradiated by

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Section: Introductionmentioning

confidence: 99%

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Yamaguchi

Kobayashi

Narita

et al. 2011

Ultrasonics Sonochemistry

135

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“…For example, antibodies were physisorbed to target cancer cells. 14,15 To achieve covalent attachment, Brook and co-workers used the sol-gel chemistry to graft a layer of amino-modified silane on titania, upon which biotin or protein was coupled. 7,16,17 Levina et al considered that titania is negatively charge at neutral pH.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles

et al. 2014

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Titanium dioxide (TiO2) or titania shows great promise in detoxification and drug delivery. To reach its full potential, it is important to interface TiO2 with biomolecules to harness their molecular recognition function. To this end, DNA attachment is an important topic. Previous work has mainly focused on long double-stranded DNA or single nucleotides. For biosensor development and targeted drug delivery, it is more important to use single-stranded oligonucleotides. Herein, the interaction between fluorescently labeled oligonucleotides and TiO2 nanoparticles is reported. The point of zero charge (PZC) of TiO2 is around 6 in water or in acetate buffer, so they are positively charged at lower pH.However, if in phosphate or citrate buffer, the particles are negatively charged even at pH ~2, suggesting strong adsorption of buffer anions. DNA adsorption takes places mainly via the phosphate backbone although the bases might also have moderate contributions. Peptide nucleic acids (PNA) with an amide backbone cannot be adsorbed. DNA adsorption is strongly affected by inorganic anions, where phosphate and citrate can strongly inhibit DNA adsorption. DNA adsorption is also promoted by adding salt or lowering pH. DNA adsorption is accompanied with fluorescence quenching and doublestranded DNA showed reduced quenching, allowing detection of DNA using TiO2 nanoparticles.3

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“…low selectivity. In this direction, many attempts to improve these systems have been made, for example combining TiO 2 with antibodies (Xu et al, 2007) or encapsulating TiO 2 in liposomes (Chihara et al, 2007), in order to produce cell death in cancer tissue alone.…”

Section: Inorganic Uv Filters: Tio 2 and Znomentioning

confidence: 99%

Inorganic UV filters

Manaia

Kaminski

Corrêa

et al. 2013

Braz. J. Pharm. Sci.

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Nowadays, concern over skin cancer has been growing more and more, especially in tropical countries where the incidence of UVA/B radiation is higher. The correct use of sunscreen is the most efficient way to prevent the development of this disease. The ingredients of sunscreen can be organic and/or inorganic sun filters. Inorganic filters present some advantages over organic filters, such as photostability, non-irritability and broad spectrum protection. Nevertheless, inorganic filters have a whitening effect in sunscreen formulations owing to the high refractive index, decreasing their esthetic appeal. Many techniques have been developed to overcome this problem and among them, the use of nanotechnology stands out. The estimated amount of nanomaterial in use must increase from 2000 tons in 2004 to a projected 58000 tons in 2020. In this context, this article aims to analyze critically both the different features of the production of inorganic filters (synthesis routes proposed in recent years) and the permeability, the safety and other characteristics of the new generation of inorganic filters.Uniterms: Skin cancer. Sunscreen. Inorganic UV filter.A preocupação com o câncer de pele hoje em dia vem crescendo cada vez mais principalmente em países tropicais, onde a incidência da radiação UVA/B é maior. O uso correto de protetores solares é a forma mais eficaz de prevenir o aparecimento desta doença. Os ativos utilizados em protetores solares podem ser filtros orgânicos e inorgânicos. Filtros inorgânicos apresentam muitas vantagens em relação aos orgânicos, tais como fotoestabilidade, ausência de irritabilidade e amplo espectro de proteção. Entretanto, em razão de apresentarem alto índice de refração, os ativos inorgânicos conferem aos protetores solares aparência esbranquiçada, diminuindo sua atratividade estética. Muitas alternativas têm sido desenvolvidas no sentido de resolver este problema e dentre elas pode-se destacar o uso da nanotecnologia. Estima-se que o uso de nanomateriais deve crescer das atuais 2000 para 58000 toneladas até 2020. Neste sentido, este trabalho tem como objetivo fazer a análise crítica abordando diferentes aspectos envolvidos tanto na obtenção de protetores solares inorgânicos (rotas de sínteses propostas nos últimos anos) quanto na permeabilidade, na segurança e em outros aspectos relacionados à nova geração de filtros solares inorgânicos. Unitermos: Câncer de pele. Protetores solares. Filtros inorgânicos.

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Photokilling cancer cells using highly cell-specific antibody–TiO2 bioconjugates and electroporation

Cited by 127 publications

References 18 publications

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles

Inorganic UV filters

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