Photoinitiated Coupling of Unmodified Monosaccharides to Iron Oxide Nanoparticles for Sensing Proteins and Bacteria

Liu, Li Hong; Dietsch, Hervé; Schurtenberger, Peter; Yan, Mingdi

doi:10.1021/bc900110x

Cited by 113 publications

(101 citation statements)

References 61 publications

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“…For a magnetic moment μ b restricted to the plane perpendicular to a b, we expect a strong correlation between the orientational behavior of the two vectors. The scattering experiments reveal the particle orientation and an appropriate measure for the orientational order is therefore cos( ) 2 ) sin(φ 1 ) 2 sin(φ 3 ) 2 , where is the angle between a b and B b (see Figure 1b). The associated orientational order parameter follows the first orientational order parameter…”

Section: Resultsmentioning

confidence: 99%

Morphology and Orientational Behavior of Silica-Coated Spindle-Type Hematite Particles in a Magnetic Field Probed by Small-Angle X-ray Scattering

et al. 2010

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Form factor and magnetic properties of silica-coated spindle-type hematite nanoparticles are determined from SAXS measurements with applied magnetic field and magnetometry measurements. The particle size, polydispersity and porosity are determined using a core-shell model for the form factor. The particles are found to align with their long axis perpendicular to the applied field. The orientational order is determined from the SAXS data and compared to the orientational order obtained from magnetometry. The direct access to both, the orientational order of the particles, and the magnetic moments allow one to determine the magnetic properties of the individual spindle-type hematite particles. We study the influence of the silica coating on the magnetic properties and find a fundamentally different behavior of silica-coated particles. The silica coating reduces the effective magnetic moment of the particles. This effect is enhanced with field strength and can be explained by superparamagnetic relaxation in the highly porous particles.

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Section: Resultsmentioning

confidence: 99%

Morphology and Orientational Behavior of Silica-Coated Spindle-Type Hematite Particles in a Magnetic Field Probed by Small-Angle X-ray Scattering

et al. 2010

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“…Although different types of nanomaterials including CdS/ZnS quantum dots, [33][34][35][36][37][38] upconverting nanoparticles, 39 magnetic nanoparticles, [40][41][42][43][44][45] and carbon nanotubes, 46 have been used for the synthesis of glyconanoparticles, the intrinsic colour changes associated with the aggregation of noble metal nanoparticles have ensured that these nanoparticles are extensively used for the development of bioassays.…”

Section: Noble Metals Used To Synthesise the Nanoparticle Corementioning

confidence: 99%

Glyconanoparticles for colorimetric bioassays

Marín

Schofield

Field

et al. 2015

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Carbohydrate molecules are involved in many of the cellular processes that are important for life. By combining the specific analyte targeting of carbohydrates with the multivalent structure and change of solution colour as a consequence of plasmonic interactions with the aggregation of metal nanoparticles, glyconanoparticles have been used extensively for the development of bioanalytical assays. The noble metals used to create the nanocore, the methodologies used to assemble the carbohydrates on the nanoparticle surface, the carbohydrate chosen for each specific target, the length of the tether that separates the carbohydrate from the nanocore and the density of carbohydrates on the surface all impact on the structural formation of metal based glyconanoparticles. This tutorial review highlights these key components, which directly impact on the selectivity and sensitivity of the developed bioassay, for the colorimetric detection of lectins, toxins and viruses.3

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“…In this study, the adhesion of E. coli to mannose-functionalized hematite (iron oxide) nanoparticles was visualized by TEM. [71] Detection has been performed with 3 H-labelled mannose. After incubation of isolated FimH together with 3 H-mannose and a competing inhibitor, the assay mixture was filtered, and the remaining radioactivity could be read out.…”

Section: Assays In a Three-dimensional Setupmentioning

confidence: 99%

The Bacterial Lectin FimH, a Target for Drug Discovery – Carbohydrate Inhibitors of Type 1 Fimbriae‐Mediated Bacterial Adhesion

2011

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Adhesion is a prerequisite for bacteria to colonize cell surfaces. To accomplish cellular adhesion, many bacteria use carbohydrate‐specific lectins, which are expressed as part of capillary protein appendages expanding from their surface, called fimbriae or pili. For bacteria, colonization of cell surfaces offers advantageous conditions to persist and multiply. For the host, however, bacterial colonization can be affiliated with severe health problems such as inflammation. Therefore, to combat bacterial adhesion and inflammatory diseases, investigation of the molecular and biophysical details of the relevant lectin–carbohydrate interactions is important. Understanding molecular carbohydrate recognition can lead to the development of high‐affinity inhibitors of bacterial lectins. That way, interfering with the bacterial attachment to surfaces proves the vision of an antiadhesion therapy, among others, against uropathogenic E. coli (UPEC). One of the most important and best investigated bacterial lectins is the mannose‐specific protein FimH, which is expressed on the tips of type 1 fimbriae. During the last 30 years, many natural as well as synthetic mannosidic ligands of FimH have been designed and tested for their inhibitory potencies. We report key results and comment on key problems and perspectives of this research.

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Photoinitiated Coupling of Unmodified Monosaccharides to Iron Oxide Nanoparticles for Sensing Proteins and Bacteria

Cited by 113 publications

References 61 publications

Morphology and Orientational Behavior of Silica-Coated Spindle-Type Hematite Particles in a Magnetic Field Probed by Small-Angle X-ray Scattering

Morphology and Orientational Behavior of Silica-Coated Spindle-Type Hematite Particles in a Magnetic Field Probed by Small-Angle X-ray Scattering

Glyconanoparticles for colorimetric bioassays

The Bacterial Lectin FimH, a Target for Drug Discovery – Carbohydrate Inhibitors of Type 1 Fimbriae‐Mediated Bacterial Adhesion

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