Photoinduced destabilization of bilayer vesicles

Frankel, David A.; Lamparski, Henry; Liman, Ulrich; O’Brien, David F.

doi:10.1021/ja00208a038

Cited by 62 publications

(38 citation statements)

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“…Moreover, the targeting of liposomes to desirable sites has been attempted. 1,2) In addition, a number of attempts have been made to develop functional liposomes, which can regulate the release of drugs responding to various stimuli, such as pH, [3][4][5][6] light 7,8) and temperature. …”

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confidence: 99%

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

et al. 2003

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Liposomes have been proposed as carriers for the delivery of molecules to cells. They have been shown to enhance the efficacy of encapsulated drugs, prolonging the circulation time and reducing side effects. Moreover, the targeting of liposomes to desirable sites has been attempted. 1,2) In addition, a number of attempts have been made to develop functional liposomes, which can regulate the release of drugs responding to various stimuli, such as pH, [3][4][5][6] light 7,8) and temperature. 9-15)The liposomes injected into blood would be opsonized by serum components, and rapidly taken up by the reticuloendothelial system (RES) including the liver and spleen. [16][17][18][19][20] This is a major problem for researchers, because it is a significant disadvantage for the delivery of drugs to non-RES tissues. Moreover, some serum components have a destabilizing effect upon lipid vesicles and thereby cause leakage of liposomal contents. For example, high-density lipoprotein (HDL) is known to cause the disintegration of liposomes. 21,22) Yatvin et al. and Weinstein et al. reported an unique approach to controlling the release of drugs using temperaturesensitive liposomes in conjunction with local hyperthermia.9-11) The barrier efficiency of the membrane abruptly decreases near the gel-to-liquid crystalline phase transition temperature (T m ) of the phospholipid membrane. The temperature-sensitive liposomes have been designed to release a drug in response to local hyperthermia, during which a tumor was heated at temperatures of 41 to 45°C. Other strategies have been used for the production of temperature-sensitive liposomes. One example is the use of polymers, which are attached to the liposome to exhibit temperature-sensitivity and cause release of the internal content above a certain temperature. 14,15) In the development of the liposome, pharmaceutical scientists have been confronted with two difficulties. The first is how to prolong circulation time. Recently, the liposome surface has been modified with GM1 ganglioside 23) and polyoxyethylene derivatives, 24,25) which have some ability to escape the RES. The second is the problem regarding the stability of liposomes in systemic circulation after injection. In general, it is favorable for a drug delivery system (DDS) to have liposomes that are stable in the blood circulation, especially for chemotherapy and gene therapy. In addition, when trying to develop stimulus-sensitive liposomes, one should consider the influence of the serum components on the function of liposomes. Liu and Huang have observed that DOPEbased pH-sensitive liposomes lost their pH-sensitivity in the presence of serum. 26)Anionic lipids are frequently used in preparing liposomes for drug delivery. In the fluid state, negatively charged liposomes composed of phosphatidylglycerol (PG) interacted with serum components and caused an increase in the leakage of the encapsulated drug. 27) Therefore, it is necessary to investigate the effects of serum components on the temperature-dependent release propert...

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confidence: 99%

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

et al. 2003

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“…Investigations by Papahadjopoulos and coworkers (Dalke et al, 1990) photocleavage of lipid chains (Kusumi et al, 1989;Anderson & Thompson, 1992b), photoinduced change in the association of polyelectrolytes with liposomes (You & Tirrell, 1991), and the photopolymerization of lipids (Frankel et al, 1989;Lamparski et al, 1992). These methods were generally designed for liposome lysis.…”

Section: Endocytosismentioning

confidence: 99%

“…The polymerization of bi-or mUlti-component liposomes has been usefully employed to form domains of enriched lipids for the insertion of transmembrane proteins into partially polymerized liposomes Tyminski et al, 1988), for the efficient photoinduced lysis of oligolamellar liposomes (Frankel et al, 1989;Lamparski et al, 1992), and for the enhancement of energy transfer between membrane surface bound dyes . In each of these cases the covalent linking of the polymerizable lipids separates the lipids into polymeric and monomeric domains (Gaub et al, 1984).…”

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Photoinduced Fusion of Liposomes

Bennett¹,

O’Brien²

1994

J. Am. Chem. Soc.

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This manuscript ,has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissenation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note wiD indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continning from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

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“…Recently Frankel et al showed that if the nonpolymerizable component prefers a nonbilayer rather than a lamellar structure, the membrane will be destabilized. 24 Certain lipids, e.g. phosphatidylethanolamines (PE), are of particular interest because they form nonbilayer structures under physiological conditions.…”

Section: Conversion From Bilayer To Nonbilayer Supramolecular Structuresmentioning

confidence: 99%

Polymerized Supramolecular Assemblies

O’Brien

Kuo

Liman

et al. 1991

Polym J

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Supramolecular assemblies of amphiphiles include monolayers, bilayers, multilayers, as well as nonlamellar structures. The recent introduction of methods to polymerize supramolecular assemblies has increased the range of chemical and physical stabilities of these new materials. Polymerized supramolecular assemblies offer opportunities to prepare new materials for both biological and materials sciences. Polymerization has proven a valuable probe of the similarities of molecular order within bilayers and multilayers, and to examine the transformation of the first into the latter. It is also possible to initiate the transformation from lamellar to nonlamellar assemblies via polymerization induced processes within the assembly. Examples of each of these types of supramolecular conversions are described. KEY WORDSBilayer / Multilayer / Vesicle / Supramolecular Assembly/ Photopolymerization / Biological membranes have long been considered ordered systems. Thus our traditional instincts were rudely surprised when molecular mobility in biomembranes was exquisitely demonstrated. 1 Since the early seventies the dynamic tension between order and mobility in the study of biomembranes has led to major advances in understanding those systems and to the creation of other nonbiological membrane systems. These innovations in understanding have led to the curent evolving view of a wide range of cooperative molecular systems, which are now termed supramolecular systems, and include micelles, monomolecular layers, bilayers, multilayers, nonlamellar lipid structures, as well as liquid crystals.Biological cell membranes are composed of lipids, proteins, and carbohydrates. Cells exploit the amphiphilic nature of lipids to create anatomical boundaries, e.g. the plasma membrane and the mitochrondrial membrane. During the early 1960s researchers demonstrated that certain classes of lipids, especially glycerophospholipids, could be used to form protein-free model membranes. Both Mueller, 2 who developed methods for tb.e preparation of supported bilayer lipid membranes (BLM), and Bangham, 3 who discovered that dried thin films of phospholipids spontaneously hydrate to yield selfsupported closed bilayer assemblies of several thousand lipid molecules (liposomes), are credited with this advance. The lipid bilayer in each model membrane is a two-dimensional fluid composed of lipids with their hydrophilic head groups exposed to water and their hydrophobic tails aggregated to exclude water. The bilayer structure is highly ordered yet dynamic 619

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Photoinduced destabilization of bilayer vesicles

Cited by 62 publications

References 1 publication

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

Alteration in the Temperature-Dependent Content Release Property of Thermosensitive Liposomes in Plasma

Photoinduced Fusion of Liposomes

Polymerized Supramolecular Assemblies

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