Photoinduced defluorinative alkylation of trifluoromethyl alkenes with carbonyl derivatives by C–C bond scission

Abstract

A practical strategy for the photoinduced defluorinative alkylation of α-trifluoromethyl styrenes with carbonyl derivatives via C–C bond cleavage was disclosed.

Organo-photoredox catalyzed gem-difluoroallylation of ketone-derived dihydroquinazolinones via C(sp3)–C bond and C(sp3)–F bond cleavage

“…If successful, such an approach would not only provide a novel disconnection in retrosynthetic analysis of gem -difluoroalkenes, but also represent a worthwhile effort for chemical invention in the field of C–C bond activation. 22…”