Photoinduced Copper-Catalyzed Regio- and Enantioselective Alkynylation of Epoxides
Jianye Li,
Sijia Li,
Guo-Hao Cui
et al.
Abstract:Epoxides are privileged and valuable electrophiles frequently utilized as versatile building blocks in synthetic chemistry to prepare diverse alcohols through ring-opening reactions. However, the catalytic stereoconvergent cross-coupling of racemic epoxides with electro-or nucleophiles has remained a persistent challenge. In this work, we present a mild method to achieve the regio-and enantioselective alkynylation of epoxides with various alkynes, resulting in the synthesis of β-chiral homopropargyl alcohols v… Show more
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