Photoinactivation of <i>Leishmania donovani infantum</i> in red cell suspensions by a flexible thiopyrylium sensitizer

Wagner, Stephen J.; Skripchenko, Andrey; Salata, Jeanne; Cardo, Lisa J.

doi:10.1111/j.1423-0410.2006.00810.x

Cited by 14 publications

(12 citation statements)

References 9 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, using in vitro experiments several methods designed to inactivate Leishmania in blood products have been tested. These include the use of riboflavin (as a photosensitizer) and ultraviolet light [105], and the photochemical treatment by amotosalen plus ultraviolet light in platelet concentrates [106,107] as well as by thiopyrylium in RBC suspensions [108].…”

Section: Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Mansueto

Seidita

Vitale

2014

Travel Medicine and Infectious Disease

View full text Add to dashboard Cite

Summary Leishmaniasis clinical spectrum ranges from cryptic infection to fatal visceral leishmaniasis. Cryptic infection can be found in blood donors from areas endemic for leishmaniasis all over the world. Although leishmaniasis is a classic vector-borne disease, cases of transfusion transmitted leishmaniasis have been reported especially in nonendemic areas. Most of these cases regarded infants or children. This paper reviews the literature on this specific feature and the impact of leishmaniasis on transfusion medicine. Relevant literature was found through PubMed. The reference lists of selected articles identified further sources. Conclusions: Blood donations by emigrants or travelers from endemic areas require special attention. Routine diagnostic methods should be implemented in blood banks to exclude donors that are positive for Leishmania, and individuals who suffered from visceral leishmaniasis should be prohibited from donating blood. The use of leukodepletion filters at the time of collection should be recommended in at-risk areas especially for high-risk recipients. ª

show abstract

Section: Preventionmentioning

confidence: 99%

“…This cross-linking makes the genome of pathogens no longer functional or able to replicate. The system has been successfully used to inactivate Leishmania in red cell suspensions [108].…”

Section: Preventionmentioning

confidence: 99%

Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Mansueto

Seidita

Vitale

2014

Travel Medicine and Infectious Disease

View full text Add to dashboard Cite

show abstract

“…Über DNA interkalierende Photoaktivatoren wie Thiopyrilium kann Leishmania nach Lichtbestrahlung um mehr als 5,7 log 10 TCID 50 inaktiviert werden [46]. Inaktivierung ist ebenfalls möglich durch Behandlung mit Psoralen und UV-Licht, wobei 4 log 10 reduziert wurden [47]; und mit Riboflavin und UV-Licht, wobei eine Reduktion von etwa 5 log 10 in Plasma und Thrombozytenkonzentraten erreicht wurde [48].…”

Section: A 42 Möglichkeiten Zur Abtrennung Und Inaktivierung Von Infunclassified

Arboprotozoen

2009

Bundesgesundheitsbl.

View full text Add to dashboard Cite

“…Previous studies have demonstrated that a DNA-intercalating flexible photosensitizer, thiopyrylium (TP), has potent activity against many viral and bacterial pathogens as well as the parasite, Leishmania donovani infantum, with little alteration of RBC storage properties under phototreatment conditions considerably more harsh than those required for robust pathogen inactivation [10,11]. In this study, we investigated whether TP can photoinactivate T. cruzi in RBC suspensions.…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

Photoinactivation of Trypanosoma cruzi in red cell suspensions with thiopyrylium

Wagner

Skripchenko

Salata

et al. 2007

Transfusion and Apheresis Science

View full text Add to dashboard Cite

Chagas disease, endemic in rural areas of Mexico, Central and South America, is caused by the protozoan parasite, Trypanosma cruzi, which is spread by the Reduviid bug and also by transfusion or organ transplant. Transmission of the organism from asymptomatic donors to immunocompromised recipients, leads to clinically apparent disease. With recent immigration patterns, T. cruzi is now becoming an increasing problem in non-endemic areas of North America and Europe. Blood screening tests for T. cruzi are being developed, and one test is currently licensed by the United States Food and Drug Administration and has been implemented in some U.S. blood centers. This study alternatively investigates the potential for a novel DNA-intercalating photosensitizer, thiopyrylium (TP), to inactivate T. cruzi in red cell suspensions. With complete inactivation using 6.3 μM of TP and 1.1 J/cm 2 red light treatment, results suggest that the organism is highly sensitive to photoinactivation under conditions much less stringent than those that have been previously demonstrated to maintain red cell (RBC) properties during 42 day storage.

show abstract

Photoinactivation of Leishmania donovani infantum in red cell suspensions by a flexible thiopyrylium sensitizer

Abstract: Leishmania is highly sensitive to photoinactivation under conditions that have been previously demonstrated to maintain RBC properties during 42 days of storage.

Cited by 14 publications

References 9 publications

Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Transfusion transmitted leishmaniasis. What to do with blood donors from endemic areas?

Arboprotozoen

Photoinactivation of Trypanosoma cruzi in red cell suspensions with thiopyrylium

Contact Info

Product

Resources

About