Photofrin PDT for early stage oesophageal cancer: Long term results in 40 patients and literature review

Moghissi, K.; Dixon, Kate; Stringer, Maurice; Thorpe, J. A. C.

doi:10.1016/j.pdpdt.2009.07.026

Cited by 49 publications

(28 citation statements)

References 40 publications

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“…7 All of the PDT cases were performed as "day-case surgery," with no overnight hospital stay. In the RR group, one death occurred and the complication rate was 8%.…”

Section: Discussionmentioning

confidence: 99%

“…This retrospective analysis matched patients between the 2 groups in a nonrandomized manner. Forty consecutive patients were treated with PDT, 7 and 40 selected patients were treated with RR. The patients were fairly balanced by age, with slightly more men receiving PDT and more women receiving RR.…”

Section: Prospective Comparative Study: Endoscopic Pdt Versus Surgicamentioning

confidence: 99%

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Where Does Photodynamic Therapy Fit in the Esophageal Cancer Treatment Jigsaw Puzzle?

Moghissi¹

2012

J Natl Compr Canc Netw

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Traditional treatment options for esophageal cancer have centered on the triad of surgery, chemotherapy, and radiotherapy. Although surgery remains the gold standard for operable disease, photodynamic therapy (PDT) is emerging as a valid minimally invasive option for select patients with inoperable disease. Years of experience with PDT for esophageal cancer seem to suggest that it may be particularly useful for treatment of early unresectable lesions, palliation of locally advanced disease, and salvage therapy for stent blockage or local tumor recurrence. Further investigation into the ideal role for PDT, perhaps through a comparative study with other nonsurgical options, may help clarify where it fits in the treatment armamentarium for esophageal cancer. Although surgery still holds "the highest place" in treatment of operable esophageal cancer, photodynamic therapy (PDT) represents an effective, minimally invasive treatment option in selected patients,

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“…7 All of the PDT cases were performed as "day-case surgery," with no overnight hospital stay. In the RR group, one death occurred and the complication rate was 8%.…”

Section: Discussionmentioning

confidence: 99%

Section: Prospective Comparative Study: Endoscopic Pdt Versus Surgicamentioning

confidence: 99%

Where Does Photodynamic Therapy Fit in the Esophageal Cancer Treatment Jigsaw Puzzle?

Moghissi¹

2012

J Natl Compr Canc Netw

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“…PDT is a minimally invasive treatment used for many malignancies, and has been demonstrated as an effective procedure for early esophageal cancer (22)(23)(24)(25). In the literature, the complete remission rate of the Photophrinbased PDT (Photofrin-PDT) for early esophageal cancer is around 70% and 5-year survival around 60% according to the reports published in the last two decades, rates comparable to those obtained with surgery (23,26,27).…”

Section: Esophageal Cancermentioning

confidence: 99%

“…In the literature, the complete remission rate of the Photophrinbased PDT (Photofrin-PDT) for early esophageal cancer is around 70% and 5-year survival around 60% according to the reports published in the last two decades, rates comparable to those obtained with surgery (23,26,27). Since the molecular mechanism of the resistance to PDT in esophageal cancer cells has hardly been investigated, an effective molecular marker available to predict response to PDT is lacking.…”

Section: Esophageal Cancermentioning

confidence: 99%

Translational research in thoracic surgery—the National Taiwan University Hospital experience

2016

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Thoracic surgeons should be more aware of the latest information about histopathological, genetic and epigenetic alterations that may influence treatment policy and patient outcome in the biomolecular era. Translational research studies often produce a promising diagnostic tool or new treatment that can be used clinically. The results of these translational studies may even change the practical guidelines and current staging system in thoracic malignancies. The following article summarizes the experiences of translational research in esophageal cancer and non-small cell lung cancer (NSCLC) at National Taiwan University Hospital in Taiwan.

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“…Moghissi and colleagues reported their long-term experience in treating patients with early stage esophageal cancer with PDT (Moghissi et al, 2009). Among 144 patients treated with PDT, 40 had T1 tumors (35 adenocarcinomas and 5 squamous cell carcinomas).…”

Section: Clinical Applicationsmentioning

confidence: 99%

Nonsurgical Management of Esophageal Cancer

Safa¹,

Reda²

2012

Esophageal Cancer - Cell and Molecular Biology, Biomarkers, Nutrition and Treatment

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Photofrin PDT for early stage oesophageal cancer: Long term results in 40 patients and literature review

Cited by 49 publications

References 40 publications

Where Does Photodynamic Therapy Fit in the Esophageal Cancer Treatment Jigsaw Puzzle?

Where Does Photodynamic Therapy Fit in the Esophageal Cancer Treatment Jigsaw Puzzle?

Translational research in thoracic surgery—the National Taiwan University Hospital experience

Nonsurgical Management of Esophageal Cancer

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