Photoelectrochemical sandwich immunoassay of CYFRA21-1 based on In₂O₃/WO₃type-II heterojunction and CdS quantum dots-polydopamine nanospheres labeling

Abstract

Using an In2O3/WO3 type-II heterojunction modified fluorine-doped tin oxide (FTO) electrode as the photoanode and CdS quantum dots (QDs)-polydopamine nanospheres (PDA NSs) as the secondary antibody (Ab2) labeling, the photoelectrochemistry...

Advances in nanoprobes‐based immunoassays

“…The biosensor showed ideal linearity from 0.5 pg mL −1 to 10 ng mL −1 , LOD of 0.29 pg mL −1 , good stability, and desirable selectivity under optimal conditions. Liu et al [62] provided an In 2 O 3 /WO 3 type-II heterojunction-modified fluorine-doped tin oxide electrode as the photoanode and CdS QDs-polydopamine nanospheres as the secondary antibody label for PECI to measure the concentration of lung cancer marker CYFRA21-1 (Figure 8c). As expected, a signal-enhanced immunosensor can be achieved by amplifying the photocurrent signal through the formation of a sandwich immunostructure, and the photocurrent was linear with the common logarithm of CYFRA21-1 ranging from 100 fg mL −1 to 50 ng mL −1 , with a LOD of 56 fg mL −1 .…”

“…[60] Copyright 2019, American Chemical Society. The sensitivity of the PECI sensor was improved by copper in situ deposition signal amplification (b) [61] , heterojunction modification (c) [62] , and energy level matching principles (d) [63] . Copyright 2019, Royal Society of Chemistry.…”

“…The biosensor showed ideal linearity from 0.5 pg mL −1 to 10 ng mL −1 , LOD of 0.29 pg mL −1 , good stability, and desirable selectivity under optimal conditions. Liu et al [62] . provided an In 2 O 3 /WO 3 type‐II heterojunction‐modified fluorine‐doped tin oxide electrode as the photoanode and CdS QDs‐polydopamine nanospheres as the secondary antibody label for PECI to measure the concentration of lung cancer marker CYFRA21‐1 (Figure 8c).…”

Co9S8 nanoparticle-functionalized CdS nanoflowers for signal-off photoelectrochemical bioanalysis of carcinoembryonic antigens with hybridization chain reaction

“…[9][10][11][12][13] Among these techniques, photoelectrochemical (PEC) methods with the merits of costefficiency, easy operation, rapid analysis, and low background values have attracted more and more attention. [14][15][16][17][18] For example, Xu et al proposed a localized surface plasmon resonance and piezoelectric effect-based co-enhanced PEC sensing strategy for accurate monitoring of prostate-specific antigens. 19 Song's group designed a switchable multiplex PEC biosensor for the simultaneous detection of Alzheimer's disease-related amyloid-beta 42 and amyloid-beta 40.…”