Photoelectrochemical Modulation of Neuronal Activity with Free-Standing Coaxial Silicon Nanowires

Parameswaran, Ramya; Carvalho-de-Souza, João L.; Jiang, Yuanwen; Burke, Michael J.; Zimmerman, John F.; Koehler, Kelliann; Philips, Andrew W.; Yi, Jaeseok; Adams, Erin J.; Bezanilla, Francisco; Tian, Bozhi

doi:10.1016/j.bpj.2017.11.2177

Cited by 30 publications

(59 citation statements)

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“…cm −2 light sensitivity of plasmonic biointerface corresponds to more than 3 orders of magnitude smaller than ocular safety limits (see Methods section). Though the transmembrane potential variation in the free membrane seems low, the variation in the attached membrane is significantly larger [27], moreover the current levels (over 100 pA) that are observed by using similar electrophysiological measurements [29] are enough to elicit action potentials. Therefore, these plasmonic biointerfaces are potentially applicable to recover the vision due to photoreceptor loss in the retina [6].…”

Section: Discussionmentioning

confidence: 99%

Plasmon-Coupled Photocapacitor Neuromodulators

Melikov

Srivastava

Karatum

et al. 2020

Preprint

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Efficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems. For that plasmonics has significant potential via boosting the light-matter interactions. However, plasmonics has been primarily used for heat-induced cell stimulation due to membrane capacitance change (i.e., optocapacitance). Instead, here we demonstrate that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the Faradaic currents below 1%. Hot-electron injection dominantly leads the enhancement of displacement current at blue spectral window, and nanoantenna effect is mainly responsible for the improvement at redspectral region. The plasmonic photocapacitor facilitates wireless modulation of single cells at 3-orders of magnitude below the maximum retinal intensity levels corresponding to one of the most sensitive optoelectronic neural interfaces. This study introduces a new way of using plasmonics for safe and effective photostimulation of neurons and paves the way toward ultrasensitive plasmon-assisted neurostimulation devices.

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Section: Discussionmentioning

confidence: 99%

Plasmon-Coupled Photocapacitor Neuromodulators

Melikov

Srivastava

Karatum

et al. 2020

Preprint

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“…The architecture of nanowires has been clarified as complex core-shell nanowires with complex chemical profiles. These advanced structures have been made from n-type and p-type silicon for making connections between the membranes of live bipolar cells and nanowires to sense the light for the recovery of vision [69]. Table 1 represents the materials have been used as nanowires for vision recovery lost due to retinal disorders.…”

Section: Structure and Overview Of Nanowiresmentioning

confidence: 99%

“…Briefly, the p-type silicon produced by materials that have one free place for accepting one extra electron on the outer layer of orbital despite the n-type silicone which produced by elements and has one extra electron in the outer layer of their orbital and electron is not involved in any bonding. However, light absorption by the n-type silicon layer will cause to the movement of an extra electron to the empty orbital of p-type silicon, and this electron movement between the n-type and p-type silicon layers lead to changing the [67,69,82]. light signals to the electrical signals [41,85].…”

Section: Light Sensationmentioning

confidence: 99%

“…Schematic of electron movement and holes toward the n-type and p-type silicon at the neural cell membrane for simulating the light senses. Light with receive to the n-type silicon containing the positive ions causes to the movement of electrons to the p-type silicon layer containing negative ions cause to senses the light and transfer produced faradic current to the cells [69]. (Refer to ACS ChemMatters online archive 2013-2014).…”

Section: Challenges and Prospectsmentioning

confidence: 99%

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Application of Nanowires for Retinal Regeneration

Kharaghani¹,

Tajbakhsh²,

Phan³

et al. 2020

Regenerative Medicine

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Nanowires aim at developing advanced architectures are gaining popularity for damaged neural systems. The retina with a complicated structure is an essential part of our visual nervous system. Any disorder inside retina could lead to blindness due to irregularity in transferring neural signals to the brain. In recent years, the emergence of nanostructures, as well as nanowires, has provided a viable means for enhancing the regeneration of retinal. Nanowires with the ability to sense light and converting it to the electrical signals simulate the extracellular electrical properties, which are the newest nanostructures for the retinal applications. The different structure of nanowires has been examined in vitro, and several others are undergoing in vivo for vision recovery. Among the structures, core-shell nanowires and functionalized nanowires with gold nanoparticles attract the attention for the regeneration of retinal neural systems. Herein, subsequently provide an introduction to the anatomy of the retina, and retinal disorders, the latest progress in the regeneration of retina and vision using nanowires will be reviewed. Also, the different structures, including core-shell and functionalized nanowires with nanoparticles, will be examined. Eventually, the point of view and perspective of applying nanowire in retinal regeneration will be offered.

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“…86 The tight evanescent field enhances localized near-field interactions with surrounding media, such as materials, biological surfaces, and other optical (plasmonic) waveguides, which provides great opportunity to miniaturize optical and optoelectronic devices in fields such as nanoscale light, communication, sensing, energy conversion, and integrated optoelectronic devices. [87][88][89][90] For a nanowire optical waveguide, one key point has been proposed: how is the light input? One technical solution is based on an optical route, that is, evanescent wave coupling relying on near-field fiber probe manipulation, which has been frequently applied to investigate the propagation performance of various nanowires.…”

Section: Nanowire Photonicsmentioning

confidence: 99%

Compositional and structural engineering of inorganic nanowires toward advanced properties and applications

Sun

et al. 2019

InfoMat

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As natural one‐dimensional confined electron transport channels and photon propagation paths, nanowires (NWs) display unmatched properties and huge potential for application in diverse fields. The ability to construct a nanoscale functional system would enable significant advances in the currently desired miniaturized device integration. To date, the basic properties of all types of nanowire crystals, including metallic NWs, as well as group IV‐related, III‐V/II‐VI compounds, and metal oxide NWs, are well understood. Regarding future work, compositional (ie, doping and alloying) and structural (defect and heterostructure) designs to flexibly realize custom‐made functionality are emphasized. Along this line, recent progress is reviewed, including the basic properties (nanowire mechanics, electronics, and photonics) and applications such as photodetectors and chemical/biological sensors. A review of the correlations between the compositional/structural configuration of nanowires and the corresponding functionality is also presented. The future development direction of this field is concluded and highlighted at the end.

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Photoelectrochemical Modulation of Neuronal Activity with Free-Standing Coaxial Silicon Nanowires

Abstract: Nat. Acad. Sci. US 112 (2015) 5407). The effect of the metal ions can be followed by bulk fluorescence measurements as well as by FCS.

Cited by 30 publications

References 0 publications

Plasmon-Coupled Photocapacitor Neuromodulators

Plasmon-Coupled Photocapacitor Neuromodulators

Application of Nanowires for Retinal Regeneration

Compositional and structural engineering of inorganic nanowires toward advanced properties and applications

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